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Surface functionalization of biomaterials for cell biology applications

Title data

Cavalcanti-Adam, Elisabetta Ada ; Feng, Wenqian:
Surface functionalization of biomaterials for cell biology applications.
In: Vrana, Nihal Engin ; Knopf-Marques, Helena ; Barthes, Julien (ed.): Biomaterials for Organ and Tissue Regeneration : New Technologies and Future Prospects. - Duxford : Woodhead Publishing , 2020 . - pp. 163-176
ISBN 978-0-08-102907-7

Abstract in another language

The extracellular environment (ECM) comprises multiple physical and chemical cues that are integrated into adhesion signaling pathways and modulate cell responses fundamental for tissue regeneration. In this chapter, we will outline the importance of ECM molecule and ECM-synthetic ligand presentations in biomaterial design. In particular, we will discuss the use of different chemical linkers that allow the control over surface immobilization, orientation, and release of such molecules and ligands. We will next present different strategies for the delivery of adhesive ligands and growth factors on material surfaces, with the aim of enhancing cell adhesion strength and signaling. A final discussion will be centered on challenges in the design of surfaces to precisely guide cell responses during tissue growth and wound healing.

Further data

Item Type: Article in a book
Refereed: Yes
Keywords: Extracellular matrix; cell adhesion; integrins; growth factors; surface micropatterning; nanopatterning
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam
Result of work at the UBT: No
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 07 Jun 2023 11:55
Last Modified: 07 Jun 2023 11:55