at Google ScholarTitle data
Di Benedetto, Adriana ; Posa, Francesca ; Marazzi, Mario ; Kalemaj, Zamira ; Grassi, Roberta ; Lo Muzio, Lorenzo ; Di Comite, Mariasevera ; Cavalcanti-Adam, Elisabetta Ada ; Grassi, Felice Roberto ; Mori, Giorgio:
Osteogenic and chondrogenic potential of the supramolecular aggregate T-LysYal®.
In: Frontiers in Endocrinology.
Vol. 11
(2020)
.
- 285.
ISSN 1664-2392
DOI: https://doi.org/10.3389/fendo.2020.00285
Abstract in another language
Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior stability, has already been proved efficient in repairing corneal epithelial cells damaged by dry conditions in vitro. We investigated the regenerative potential of T-Lys in the hard tissues bone and cartilage. We have previously demonstrated that cells isolated from the tooth germ, Dental Bud Stem Cells (DBSCs), differentiate into osteoblast-like cells, representing a promising source of MSCs for bone regeneration. Herewith, we show that T-Lys treatment stimulates the expression of typical osteoblastic markers, such as Runx-2, Collagen I (Col1) and Alkaline Phosphatase (ALP), determining a higher production of mineralized matrix nodules. In addition, we found that T-Lys treatment positively affects αVβ3 integrin expression, key integrin in the osteoblastic commitment, leading to the formation of focal adhesions (FAs). The efficacy of T-Lys was also tested on chondrogenic differentiation starting from human articular chondrocytes (HACs) resulting in an increase of differentiation markers and cell number.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam |
| Result of work at the UBT: | No |
| DDC Subjects: | 600 Technology, medicine, applied sciences > 620 Engineering |
| Date Deposited: | 07 Jun 2023 11:45 |
| Last Modified: | 07 Jun 2023 11:45 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81214 |