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Osteogenic and chondrogenic potential of the supramolecular aggregate T-LysYal®

Title data

Di Benedetto, Adriana ; Posa, Francesca ; Marazzi, Mario ; Kalemaj, Zamira ; Grassi, Roberta ; Lo Muzio, Lorenzo ; Di Comite, Mariasevera ; Cavalcanti-Adam, Elisabetta Ada ; Grassi, Felice Roberto ; Mori, Giorgio:
Osteogenic and chondrogenic potential of the supramolecular aggregate T-LysYal®.
In: Frontiers in Endocrinology. Vol. 11 (2020) . - 285.
ISSN 1664-2392

Abstract in another language

Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior stability, has already been proved efficient in repairing corneal epithelial cells damaged by dry conditions in vitro. We investigated the regenerative potential of T-Lys in the hard tissues bone and cartilage. We have previously demonstrated that cells isolated from the tooth germ, Dental Bud Stem Cells (DBSCs), differentiate into osteoblast-like cells, representing a promising source of MSCs for bone regeneration. Herewith, we show that T-Lys treatment stimulates the expression of typical osteoblastic markers, such as Runx-2, Collagen I (Col1) and Alkaline Phosphatase (ALP), determining a higher production of mineralized matrix nodules. In addition, we found that T-Lys treatment positively affects αVβ3 integrin expression, key integrin in the osteoblastic commitment, leading to the formation of focal adhesions (FAs). The efficacy of T-Lys was also tested on chondrogenic differentiation starting from human articular chondrocytes (HACs) resulting in an increase of differentiation markers and cell number.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam
Result of work at the UBT: No
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 07 Jun 2023 11:45
Last Modified: 07 Jun 2023 11:45