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BMP‐2 signaling and mechanotransduction synergize to drive osteogenic differentiation via YAP/TAZ

Title data

Wei, Qiang ; Holle, Andrew ; Li, Jie ; Posa, Francesca ; Biagioni, Francesca ; Croci, Ottavio ; Benk, Amelie S. ; Young, Jennifer ; Noureddine, Fatima ; Deng, Jie ; Zhang, Man ; Inman, Gareth J. ; Spatz, Joachim P. ; Campaner, Stefano ; Cavalcanti-Adam, Elisabetta Ada:
BMP‐2 signaling and mechanotransduction synergize to drive osteogenic differentiation via YAP/TAZ.
In: Advanced Science. Vol. 7 (2020) Issue 15 . - 1902931.
ISSN 2198-3844

Abstract in another language

Growth factors and mechanical cues synergistically affect cellular functions, triggering a variety of signaling pathways. The molecular levels of such cooperative interactions are not fully understood. Due to its role in osteogenesis, the growth factor bone morphogenetic protein 2 (BMP-2) is of tremendous interest for bone regenerative medicine, osteoporosis therapeutics, and beyond. Here, contribution of BMP-2 signaling and extracellular mechanical cues to the osteogenic commitment of C2C12 cells is investigated. It is revealed that these two distinct pathways are integrated at the transcriptional level to provide multifactorial control of cell differentiation. The activation of osteogenic genes requires the cooperation of BMP-2 pathway-associated Smad1/5/8 heteromeric complexes and mechanosensitive YAP/TAZ translocation. It is further demonstrated that the Smad complexes remain bound onto and active on target genes, even after BMP-2 removal, suggesting that they act as a “molecular memory unit.” Thus, synergistic stimulation with BMP-2 and mechanical cues drives osteogenic differentiation in a programmable fashion.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam
Result of work at the UBT: No
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 07 Jun 2023 11:36
Last Modified: 07 Jun 2023 11:36