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Bioengineering bone tissue with 3D printed scaffolds in the presence of oligostilbenes

Title data

Posa, Francesca ; Di Benedetto, Adriana ; Ravagnan, Giampietro ; Cavalcanti-Adam, Elisabetta Ada ; Lo Muzio, Lorenzo ; Percoco, Gianluca ; Mori, Giorgio:
Bioengineering bone tissue with 3D printed scaffolds in the presence of oligostilbenes.
In: Materials. Vol. 13 (2020) Issue 20 . - 4471.
ISSN 1996-1944
DOI: https://doi.org/10.3390/ma13204471

Abstract in another language

Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehiscence have been obtained using adult mesenchymal stem cells (MSCs) integrated with biocompatible scaffolds. The geometry of the scaffold has critical effects on cell adhesion, proliferation and differentiation. Many cytokines and compounds have been demonstrated to be effective in promoting MSCs osteogenic differentiation. Oligostilbenes, such as Resveratrol (Res) and Polydatin (Pol), can increase MSCs osteoblastic features. 3D printing is an excellent technique to create scaffolds customized for the lesion and thus optimized for the patient. In this work we analyze osteoblastic features of adult MSCs integrated with 3D-printed polycarbonate scaffolds differentiated in the presence of oligostilbenes.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: bone; mesenchymal stem cells; biomaterial; polycarbonate; resveratrol; polydatin; osteogenic differentiation; focal adhesions; bone health
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam
Result of work at the UBT: No
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 07 Jun 2023 11:03
Last Modified: 07 Jun 2023 11:03
URI: https://eref.uni-bayreuth.de/id/eprint/81220