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Posa, Francesca ; Di Benedetto, Adriana ; Ravagnan, Giampietro ; Cavalcanti-Adam, Elisabetta Ada ; Lo Muzio, Lorenzo ; Percoco, Gianluca ; Mori, Giorgio:
Bioengineering bone tissue with 3D printed scaffolds in the presence of oligostilbenes.
In: Materials.
Bd. 13
(2020)
Heft 20
.
- 4471.
ISSN 1996-1944
DOI: https://doi.org/10.3390/ma13204471
Abstract
Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehiscence have been obtained using adult mesenchymal stem cells (MSCs) integrated with biocompatible scaffolds. The geometry of the scaffold has critical effects on cell adhesion, proliferation and differentiation. Many cytokines and compounds have been demonstrated to be effective in promoting MSCs osteogenic differentiation. Oligostilbenes, such as Resveratrol (Res) and Polydatin (Pol), can increase MSCs osteoblastic features. 3D printing is an excellent technique to create scaffolds customized for the lesion and thus optimized for the patient. In this work we analyze osteoblastic features of adult MSCs integrated with 3D-printed polycarbonate scaffolds differentiated in the presence of oligostilbenes.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | bone; mesenchymal stem cells; biomaterial; polycarbonate; resveratrol; polydatin; osteogenic differentiation; focal adhesions; bone health |
| Institutionen der Universität: | Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Zelluläre Biomechanik > Lehrstuhl Zelluläre Biomechanik - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften |
| Eingestellt am: | 07 Jun 2023 11:03 |
| Letzte Änderung: | 07 Jun 2023 11:03 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81220 |