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Mimicking Bone Extracellular Matrix : From BMP‐2‐Derived Sequences to Osteogenic‐Multifunctional Coatings

Title data

Oliver‐Cervelló, Lluís ; Martin‐Gómez, Helena ; Mandakhbayar, Nandin ; Jo, Young‐Woo ; Cavalcanti-Adam, Elisabetta Ada ; Kim, Hae‐Won ; Ginebra, Maria‐Pau ; Lee, Jung‐Hwan ; Mas‐Moruno, Carlos:
Mimicking Bone Extracellular Matrix : From BMP‐2‐Derived Sequences to Osteogenic‐Multifunctional Coatings.
In: Advanced Healthcare Materials. Vol. 11 (2022) Issue 20 . - 2201339.
ISSN 2192-2659
DOI: https://doi.org/10.1002/adhm.202201339

Abstract in another language

Cell–material interactions are regulated by mimicking bone extracellular matrix on the surface of biomaterials. In this regard, reproducing the extracellular conditions that promote integrin and growth factor (GF) signaling is a major goal to trigger bone regeneration. Thus, the use of synthetic osteogenic domains derived from bone morphogenetic protein 2 (BMP-2) is gaining increasing attention, as this strategy is devoid of the clinical risks associated with this molecule. In this work, the wrist and knuckle epitopes of BMP-2 are screened to identify peptides with potential osteogenic properties. The most active sequences (the DWIVA motif and its cyclic version) are combined with the cell adhesive RGD peptide (linear and cyclic variants), to produce tailor-made biomimetic peptides presenting the bioactive cues in a chemically and geometrically defined manner. Such multifunctional peptides are next used to functionalize titanium surfaces. Biological characterization with mesenchymal stem cells demonstrates the ability of the biointerfaces to synergistically enhance cell adhesion and osteogenic differentiation. Furthermore, in vivo studies in rat calvarial defects prove the capacity of the biomimetic coatings to improve new bone formation and reduce fibrous tissue thickness. These results highlight the potential of mimicking integrin-GF signaling with synthetic peptides, without the need for exogenous GFs.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam
Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics
Result of work at the UBT: No
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 07 Jun 2023 06:29
Last Modified: 07 Jun 2023 06:29
URI: https://eref.uni-bayreuth.de/id/eprint/81237