at Google ScholarTitle data
Zambarda, Chiara ; González, Carlos Pérez ; Schoenit, Andreas ; Veits, Nisha ; Schimmer, Clara ; Jung, Raimund ; Ollech, Dirk ; Christian, Joel ; Roca-Cusachs, Pere ; Trepat, Xavier ; Cavalcanti-Adam, Elisabetta Ada:
Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility.
In: European Journal of Cell Biology.
Vol. 101
(2022)
Issue 4
.
- 151274.
ISSN 1618-1298
DOI: https://doi.org/10.1016/j.ejcb.2022.151274
Abstract in another language
Several factors present in the extracellular environment regulate epithelial cell adhesion and dynamics. Among them, growth factors such as EGF, upon binding to their receptors at the cell surface, get internalized and directly activate the acto-myosin machinery. In this study we present the effects of EGF on the contractility of epithelial cancer cell colonies in confined geometry of different sizes. We show that the extent to which EGF triggers contractility scales with the cluster size and thus the number of cells. Moreover, the collective contractility results in a radial distribution of traction forces, which are dependent on integrin β1 peripheral adhesions and transmitted to neighboring cells through adherens junctions. Taken together, EGF-induced contractility acts on the mechanical crosstalk and linkage between the cell-cell and cell-matrix compartments, regulating collective responses.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Keywords: | Collective contractility; Actomyosin; EGF; Traction forces; Adherens junctions; Micropatterning |
| Institutions of the University: | Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam |
| Result of work at the UBT: | No |
| DDC Subjects: | 600 Technology, medicine, applied sciences > 620 Engineering |
| Date Deposited: | 07 Jun 2023 06:33 |
| Last Modified: | 07 Jun 2023 06:33 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81241 |