bei Google ScholarTitelangaben
Zambarda, Chiara ; González, Carlos Pérez ; Schoenit, Andreas ; Veits, Nisha ; Schimmer, Clara ; Jung, Raimund ; Ollech, Dirk ; Christian, Joel ; Roca-Cusachs, Pere ; Trepat, Xavier ; Cavalcanti-Adam, Elisabetta Ada:
Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility.
In: European Journal of Cell Biology.
Bd. 101
(2022)
Heft 4
.
- 151274.
ISSN 1618-1298
DOI: https://doi.org/10.1016/j.ejcb.2022.151274
Abstract
Several factors present in the extracellular environment regulate epithelial cell adhesion and dynamics. Among them, growth factors such as EGF, upon binding to their receptors at the cell surface, get internalized and directly activate the acto-myosin machinery. In this study we present the effects of EGF on the contractility of epithelial cancer cell colonies in confined geometry of different sizes. We show that the extent to which EGF triggers contractility scales with the cluster size and thus the number of cells. Moreover, the collective contractility results in a radial distribution of traction forces, which are dependent on integrin β1 peripheral adhesions and transmitted to neighboring cells through adherens junctions. Taken together, EGF-induced contractility acts on the mechanical crosstalk and linkage between the cell-cell and cell-matrix compartments, regulating collective responses.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | Collective contractility; Actomyosin; EGF; Traction forces; Adherens junctions; Micropatterning |
| Institutionen der Universität: | Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Zelluläre Biomechanik > Lehrstuhl Zelluläre Biomechanik - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften |
| Eingestellt am: | 07 Jun 2023 06:33 |
| Letzte Änderung: | 07 Jun 2023 06:33 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81241 |