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Hidden Structural Features of Multicompartment Micelles Revealed by Cryogenic Transmission Electron Tomography

Title data

Löbling, Tina I. ; Haataja, Johannes S. ; Synatschke, Christopher V. ; Schacher, Felix H. ; Müller, Melanie ; Hanisch, Andreas ; Gröschel, André H. ; Müller, Axel H. E.:
Hidden Structural Features of Multicompartment Micelles Revealed by Cryogenic Transmission Electron Tomography.
In: ACS Nano. Vol. 8 (2014) Issue 11 . - pp. 11330-11340.
ISSN 1936-086X

Abstract in another language

The demand for ever more complex nanostructures in materials and soft matter nanoscience also requires sophisticated characterization tools for reliable visualization and interpretation of internal morphological features. Here, we address both aspects and present synthetic concepts for the compartmentalization of nanoparticle peripheries as well as their in situ tomographic characterization. We first form negatively charged spherical multicompartment micelles from ampholytic triblock terpolymers in aqueous media, followed by interpolyelectrolyte complex (IPEC) formation of the anionic corona with bis-hydrophilic cationic/neutral diblock copolymers. At a 1:1 stoichiometric ratio of anionic and cationic charges, the so-formed IPECs are charge neutral and thus phase separate from solution (water). The high chain density of the ionic grafts provides steric stabilization through the neutral PEO corona of the grafted diblock copolymer and suppresses collapse of the IPEC; instead, the dense grafting results in defined nanodomains oriented perpendicular to the micellar core. We analyze the 3D arrangements of the complex and purely organic compartments, in situ, by means of cryogenic transmission electron microscopy (cryo-TEM) and tomography (cryo-ET). We study the effect of block lengths of the cationic and nonionic block on IPEC morphology, and while 2D cryo-TEM projections suggest similar morphologies, cryo-ET and computational 3D reconstruction reveal otherwise hidden structural features, e.g., planar IPEC brushes emanating from the micellar core.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: cryo-electron tomography; interpolyelectrolyte complexes; multicompartment micelles; nanoparticles; self-assembly
Institutions of the University: Research Institutions > Central research institutes > Bayerisches Zentrum für Batterietechnik - BayBatt
Research Institutions
Research Institutions > Central research institutes
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Polymer Materials for Electrochemical Storage > Chair Polymer Materials for Electrochemical Storage - Univ.-Prof. Dr. André Gröschel
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 24 Jul 2023 11:26
Last Modified: 02 Aug 2023 07:53