bei Google ScholarTitelangaben
Cauwenbergh, Robin ; Sahoo, Prakash Kumar ; Maiti, Rakesh ; Mathew, Abra ; Kuniyil, Rositha ; Das, Shoubhik:
Selective synthesis of functionalized linear aliphatic primary amines via decarboxylative radical-polar crossover.
In: Green Chemistry.
Bd. 26
(2024)
Heft 1
.
- S. 264-276.
ISSN 1463-9262
DOI: https://doi.org/10.1039/D3GC03187J
Abstract
Primary aliphatic amines are crucial, and at the very least, millions of tons are required every year. Therefore, significant interest has grown in finding new chemical routes for their synthesis. Additionally, to comply with sustainability requirements, synthetic routes using inexpensive feedstocks are highly prioritized. In this regard, the hydroaminoalkylation (HAA) reaction is highly desirable due to the wide availability and lower price of olefins. Although photoredox catalysis is already known for synthesizing amines, the synthesis of linear aliphatic amines is mostly limited to hydroaminomethylation (HAM) reactions and has never been applied to the synthesis of longer-chain linear aliphatic primary amines. Considering this, the synthesis of functionalized linear aliphatic primary amines is demonstrated by using the decarboxylative radical-polar crossover process, which yielded a wide range of functionalized linear aliphatic amines with excellent yields. The strength of this method is demonstrated by the synthesis of existing drugs and late-stage transformations of complex pharmaceuticals, and elaborated with detailed mechanistic studies.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Organische Chemie I - Photo- und Elektrokatalyse für Nachhaltigkeit > Lehrstuhl Organische Chemie I - Photo- und Elektrokatalyse für Nachhaltigkeit - Univ.-Prof. Dr. Das Shoubhik Fakultäten Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Organische Chemie I - Photo- und Elektrokatalyse für Nachhaltigkeit |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 08 Dec 2023 08:21 |
| Letzte Änderung: | 17 Sep 2024 12:19 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/87995 |