at Google ScholarTitle data
Cauwenbergh, Robin ; Sahoo, Prakash Kumar ; Maiti, Rakesh ; Mathew, Abra ; Kuniyil, Rositha ; Das, Shoubhik:
Selective synthesis of functionalized linear aliphatic primary amines via decarboxylative radical-polar crossover.
In: Green Chemistry.
(2023)
.
ISSN 1463-9262
DOI: https://doi.org/10.1039/D3GC03187J
Abstract in another language
Primary aliphatic amines are crucial, and at the very least, millions of tons are required every year. Therefore, significant interest has grown in finding new chemical routes for their synthesis. Additionally, to comply with sustainability requirements, synthetic routes using inexpensive feedstocks are highly prioritized. In this regard, the hydroaminoalkylation (HAA) reaction is highly desirable due to the wide availability and lower price of olefins. Although photoredox catalysis is already known for synthesizing amines, the synthesis of linear aliphatic amines is mostly limited to hydroaminomethylation (HAM) reactions and has never been applied to the synthesis of longer-chain linear aliphatic primary amines. Considering this, the synthesis of functionalized linear aliphatic primary amines is demonstrated by using the decarboxylative radical-polar crossover process, which yielded a wide range of functionalized linear aliphatic amines with excellent yields. The strength of this method is demonstrated by the synthesis of existing drugs and late-stage transformations of complex pharmaceuticals, and elaborated with detailed mechanistic studies.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry I > Chair Organic Chemistry I - Univ.-Prof. Dr. Das Shoubhik |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 08 Dec 2023 08:21 |
| Last Modified: | 08 Dec 2023 08:21 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/87995 |