Manganese-catalyzed Dehydrogenation of Amido Alcohols with Liberation of Hydrogen for the Synthesis of Oxazoles

Titelangaben

Leinert, Max ; Irrgang, Torsten ; Kempe, Rhett:
Manganese-catalyzed Dehydrogenation of Amido Alcohols with Liberation of Hydrogen for the Synthesis of Oxazoles.
In: ChemCatChem. Bd. 15 (2023) Heft 22 . - e202301042.
ISSN 1867-3899
DOI: https://doi.org/10.1002/cctc.202301042

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Abstract

Abstract Syntheses of important classes of (heterocyclic) compounds, the sustainable generation of hydrogen, and the use of abundantly available metals are highly desirable. We introduce here a catalytic oxazole synthesis. Our reaction is a regio selective, one-pot reaction and starts from esters and amino alcohols. Both are abundantly and diversely available and inexpensive starting materials. Hydrogen is liberated during the reaction and a molecular earth-abundant metal catalyst, a Mn(I) compound, mediates the reaction most effectively - and more efficiently than Ir and Ru catalysts. None of the oxazole derivatives synthesized, except the screening substrate and an active ingredient of a drug (an application), have been reported in literature yet.