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Structure-Property Relationship Based on the Amino Acid Composition of Recombinant Spider Silk Proteins for Potential Biomedical Applications

Title data

Lentz, Sarah ; Trossmann, Vanessa T. ; Borkner, Christian B. ; Beyersdorfer, Vivien ; Rottmar, Markus ; Scheibel, Thomas:
Structure-Property Relationship Based on the Amino Acid Composition of Recombinant Spider Silk Proteins for Potential Biomedical Applications.
In: ACS Applied Materials & Interfaces. Vol. 14 (2022) Issue 28 . - pp. 31751-31766.
ISSN 1944-8252
DOI: https://doi.org/10.1021/acsami.2c09590

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

Improving biomaterials by engineering application-specific and adjustable properties is of increasing interest. Most of the commonly available materials fulfill the mechanical and physical requirements of relevant biomedical applications, but they lack biological functionality, including biocompatibility and prevention of microbial infestation. Thus, research has focused on customizable, application-specific, and modifiable surface coatings to cope with the limitations of existing biomaterials. In the case of adjustable degradation and configurable interaction with body fluids and cells, these coatings enlarge the applicability of the underlying biomaterials. Silks are interesting coating materials, e.g., for implants, since they exhibit excellent biocompatibility and mechanical properties. Herein, we present putative implant coatings made of five engineered recombinant spider silk proteins derived from the European garden spider Araneus diadematus fibroins (ADF), differing in amino acid sequence and charge. We analyzed the influence of the underlying amino acid composition on wetting behavior, blood compatibility, biodegradability, serum protein adsorption, and cell adhesion. The outcome of the comparison indicates that spider silk coatings can be engineered for explicit biomedical applications.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: recombinant spider silk proteins; blood coagulation; enzymatic degradation; cell adhesion; protein adsorption; surface properties
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 21 Dec 2023 06:37
Last Modified: 21 Dec 2023 06:37
URI: https://eref.uni-bayreuth.de/id/eprint/88113