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Selective Topography Directed Cell Adhesion on Spider Silk Surfaces

Title data

Lentz, Sarah ; Trossmann, Vanessa T. ; Scheibel, Thomas:
Selective Topography Directed Cell Adhesion on Spider Silk Surfaces.
In: Advanced Materials Interfaces. Vol. 10 (2023) Issue 5 . - 2201936.
ISSN 2196-7350

Abstract in another language

For tissue engineering applications, guided cell interaction with a biomaterial surface is one essential feature since, in natural tissue, cells constantly interact with their extracellular matrix, which provides different topographical, mechanical and biochemical stimuli. Therefore, the introduction of topographical surface features is one promising approach to direct material-cell interactions. In this study, maskless lithography and soft lithographic methods are used to produce recombinant spider silk films with size gradient patterns, including grooves, circles, squares, triangles, and stars, to enhance specific cell attachment. The influence of surface features on cell behavior is analyzed using eight different cell lines. It can be shown that surface indentations provide cellular attachment sites and guiding structures for restructuring, aligning, and adopting cell morphology, with a relation of cell to feature size for some of the cell lines investigated. Therefore, specific topographical surface modifications can be used to guide selective cell adhesion, allowing the generation of tissue-specifically modified implant surfaces in the future.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: bioselectivity; contact guidance; correlative microscopy; geometric confinement; gradient materials
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 22 Dec 2023 06:49
Last Modified: 22 Dec 2023 06:49