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Missing genomic resources for the next generation of environmental risk assessment

Title data

Roell, Marc-Sven ; Ott, Mark-Christoph ; Mair, Magdalena ; Pamminger, Tobias:
Missing genomic resources for the next generation of environmental risk assessment.
In: Environmental Science & Technology. (21 January 2024) .
ISSN 0013-936X
DOI: https://doi.org/10.1021/acs.est.3c08701

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Abstract in another language

Environmental risk assessment traditionally relies on a wide range of in vivo testing to assess the potential hazards of chemicals in the environment. These tests are often time-consuming and costly and can cause test organisms’ suffering. Recent developments of reliable low-cost alternatives, both in vivo- and in silico-based, opened the door to reconsider current toxicity assessment. However, many of these new approach methodologies (NAMs) rely on high-quality annotated genomes for surrogate species of regulatory risk assessment. Currently, a lack of genomic information slows the process of NAM development. Here, we present a phylogenetically resolved overview of missing genomic resources for surrogate species within a regulatory ecotoxicological risk assessment. We call for an organized and systematic effort within the (regulatory) ecotoxicological community to provide these missing genomic resources. Further, we discuss the potential of a standardized genomic surrogate species landscape to enable a robust and nonanimal-reliant ecotoxicological risk assessment in the systems ecotoxicology era.
Competing Interest Statement
The authors have declared no competing interest.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: predictive ecotoxicology; genomics; systems ecotoxicology; new approach methodologies; next generation risk assessment
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Research Institutions > Central research institutes > Bayreuth Center of Ecology and Environmental Research- BayCEER
Faculties
Research Institutions
Research Institutions > Central research institutes
Result of work at the UBT: Yes
DDC Subjects: 500 Science
500 Science > 570 Life sciences, biology
Date Deposited: 24 Jan 2024 06:13
Last Modified: 24 Jan 2024 06:13
URI: https://eref.uni-bayreuth.de/id/eprint/88323

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