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Secondary Self‐Assembly of Supramolecular Nanotubes into Tubisomes and Their Activity on Cells

Titelangaben

Brendel, Johannes C. ; Sanchis, Joaquin ; Catrouillet, Sylvain ; Czuba, Ewa ; Chen, Moore Z. ; Long, Benjamin M. ; Nowell, Cameron ; Johnston, Angus ; Jolliffe, Katrina A. ; Perrier, Sébastien:
Secondary Self‐Assembly of Supramolecular Nanotubes into Tubisomes and Their Activity on Cells.
In: Angewandte Chemie International Edition. Bd. 57 (2018) Heft 51 . - S. 16678-16682.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.201808543

Abstract

The properties and structures of viruses are directly related to the three-dimensional structure of their capsid proteins, which arises from a combination of hydrophobic and supramolecular interactions, such as hydrogen bonds. The design of synthetic materials demonstrating similar synergistic interactions still remains a challenge. Herein, we report the synthesis of a polymer/cyclic peptide conjugate that combines the capability to form supramolecular nanotubes via hydrogen bonds with the properties of an amphiphilic block copolymer. The analysis of aqueous solutions by scattering and imaging techniques revealed a barrel-shaped alignment of single peptide nanotubes into a large tubisome (length: 260 nm (from SANS)) with a hydrophobic core (diameter: 16 nm) and a hydrophilic shell. These systems, which have a structure that is similar to those of viruses, were tested in vitro to elucidate their activity on cells. Remarkably, the rigid tubisomes are able to perforate the lysosomal membrane in cells and release a small molecule into the cytosol.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie I
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie I > Lehrstuhl Makromolekulare Chemie I - Univ.-Prof. Dr. Johannes C. Brendel
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Eingestellt am: 21 Feb 2024 08:16
Letzte Änderung: 02 Mai 2024 07:39
URI: https://eref.uni-bayreuth.de/id/eprint/88571