at Google ScholarTitle data
Brendel, Johannes C. ; Sanchis, Joaquin ; Catrouillet, Sylvain ; Czuba, Ewa ; Chen, Moore Z. ; Long, Benjamin M. ; Nowell, Cameron ; Johnston, Angus ; Jolliffe, Katrina A. ; Perrier, Sébastien:
Secondary Self‐Assembly of Supramolecular Nanotubes into Tubisomes and Their Activity on Cells.
In: Angewandte Chemie International Edition.
Vol. 57
(2018)
Issue 51
.
- pp. 16678-16682.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.201808543
Abstract in another language
The properties and structures of viruses are directly related to the three-dimensional structure of their capsid proteins, which arises from a combination of hydrophobic and supramolecular interactions, such as hydrogen bonds. The design of synthetic materials demonstrating similar synergistic interactions still remains a challenge. Herein, we report the synthesis of a polymer/cyclic peptide conjugate that combines the capability to form supramolecular nanotubes via hydrogen bonds with the properties of an amphiphilic block copolymer. The analysis of aqueous solutions by scattering and imaging techniques revealed a barrel-shaped alignment of single peptide nanotubes into a large tubisome (length: 260 nm (from SANS)) with a hydrophobic core (diameter: 16 nm) and a hydrophilic shell. These systems, which have a structure that is similar to those of viruses, were tested in vitro to elucidate their activity on cells. Remarkably, the rigid tubisomes are able to perforate the lysosomal membrane in cells and release a small molecule into the cytosol.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I > Chair Macromolecular Chemistry I - Univ.-Prof. Dr. Johannes C. Brendel |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 21 Feb 2024 08:16 |
| Last Modified: | 02 May 2024 07:39 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/88571 |