Anisotropy in Antimicrobial Bottle Brush Copolymers and Its Influence on Biological Activity

Title data

Lehnen, Anne-Catherine ; Kogikoski Jr., Sergio ; Stensitzki, Till ; AlSawaf, Ahmad ; Bapolisi, Alain M. ; Wolff, Martin ; De Breuck, Jonas ; Müller-Werkmeister, Henrike M. ; Chiantia, Salvatore ; Bald, Ilko ; Leiske, Meike N. ; Hartlieb, Matthias:
Anisotropy in Antimicrobial Bottle Brush Copolymers and Its Influence on Biological Activity.
In: Advanced Functional Materials. Vol. 34 (2024) Issue 10 . - 2312651.
ISSN 1616-3028
DOI: https://doi.org/10.1002/adfm.202312651

Official URL:

Abstract in another language

Antimicrobial polymers are a promising alternative to conventional antibiotics in the fight against antimicrobial resistance. Cationic bottle brush copolymers have shown to be superior to linear topologies in previous studies. Herein, the aspect ratio of such polymers is varied creating differently shaped confined unimolecular structures with varying degrees of side chain mobility. Using reversible addition-fragmentation chain-transfer (RAFT) polymerization, bottle brushes are produced in a one-pot procedure. The morphology is confirmed by atomic force microscopy. The hydrophobicity, as determined via high performance-liquid chromatography (HPLC) analysis, is drastically influenced by the topology. Using Fourier-transform infrared (FTIR) spectroscopy, it is found that polymers with a high side chain mobility and increased global hydrophilicity, are less hydrated, and have stronger intramolecular hydrogen bonds. A phase segregated morphology leading to unimolecular micellization is assumed. Biological tests reveal increased antimicrobial activity for such segregated polymers. Their excellent hemocompatibility results in highly selective antimicrobial polymers whose adaptability seems to be a key feature in their excellent performance. This study highlights the tremendous importance of structural control in antimicrobial polymers.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Keywords:	anisotropy; antimicrobial polymers; aspect ratio; bottle brush copolymers; RAFT polymerization
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Junior Professor Sustainable and Functional Polymer Systems > Junior Professor Sustainable and Functional Polymer Systems - Juniorprof. Dr. Meike Leiske
Result of work at the UBT:	No
DDC Subjects:	500 Science
Date Deposited:	02 Apr 2024 08:59
Last Modified:	02 Apr 2024 08:59
URI:	https://eref.uni-bayreuth.de/id/eprint/89098