at Google ScholarTitle data
Leinert, Max ; Irrgang, Torsten ; Kempe, Rhett:
A Catalytic Version of the Knorr Pyrrole Synthesis Permits Access to Pyrroles and Pyridines.
In: Journal of the American Chemical Society.
(November 2024)
.
ISSN 1520-5126
DOI: https://doi.org/10.1021/jacs.4c13266
Abstract in another language
Aromatic N-heterocycles, such as pyrroles and pyridines, are important natural products and bulk and fine chemicals with numerous applications as active ingredients of pharmaceuticals and agrochemicals, as catalysts, and in materials sciences. We report here a catalytic version of the Knorr pyrrole synthesis in which simple and diversely available starting materials, such as 1,2-amino alcohols or 1,3-amino alcohols and keto esters, undergo a dehydrogenative coupling to form pyrroles and pyridines, respectively. Our reaction forms hydrogen as a collectible (and usable) byproduct and is mediated by a well-defined Mn catalyst. The synthesis of highly functionalized heterocycles and applications was demonstrated, and 35 compounds, not yet reported in the literature, were introduced.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II > Chair Inorganic Chemistry II - Univ.-Prof. Dr. Rhett Kempe |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 13 Nov 2024 06:39 |
| Last Modified: | 13 Nov 2024 06:39 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/91055 |