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Exploring the dynamics of messenger ribonucleoprotein-mediated translation repression

Title data

Meyer, Julia ; Payr, Marco ; Duss, Olivier ; Hennig, Janosch:
Exploring the dynamics of messenger ribonucleoprotein-mediated translation repression.
In: Biochemical Society Transactions. Vol. 52 (2024) Issue 6 . - pp. 2267-2279.
ISSN 1470-8752
DOI: https://doi.org/10.1042/bst20231240

Official URL: Volltext

Abstract in another language

Translational control is crucial for well-balanced cellular function and viability of organisms. Different mechanisms have evolved to up- and down-regulate protein synthesis, including 3′ untranslated region (UTR)-mediated translation repression. RNA binding proteins or microRNAs interact with regulatory sequence elements located in the 3′ UTR and interfere most often with the rate-limiting initiation step of translation. Dysregulation of post-transcriptional gene expression leads to various kinds of diseases, emphasizing the significance of understanding the mechanisms of these processes. So far, only limited mechanistic details about kinetics and dynamics of translation regulation are understood. This mini-review focuses on 3′ UTR-mediated translational regulation mechanisms and demonstrates the potential of using single-molecule fluorescence-microscopy for kinetic and dynamic studies of translation regulation in vivo and in vitro.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: RNP dynamics; RNP structure; single-molecule fluorescence microscopy; translation regulation
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry IV - Biophysical Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry IV - Biophysical Chemistry > Chair Biochemistry IV - Biophysical Chemistry - Univ.-Prof. Dr. Janosch Hennig
Research Institutions > Central research institutes > Nordbayerisches Zentrum für NMR-Spektroskopie - NMR-Zentrum
Research Institutions
Research Institutions > Central research institutes
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 29 Nov 2024 07:43
Last Modified: 29 Jan 2025 12:54
URI: https://eref.uni-bayreuth.de/id/eprint/91278