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Guo, Longhua ; Guo, Fengli ; Zhang, Shasha ; Zeng, An ; Yi, Kexi ; McClain, Melainia ; Kuhn, Claus-D. ; Parmely, Tari ; Alvarado, Alejandro Sánchez:
Oogenesis involves a novel nuclear envelop remodeling mechanism in Schmidtea mediterranea.
In: Developmental Biology.
Bd. 520
(2025)
.
- S. 13-20.
ISSN 1095-564X
DOI: https://doi.org/10.1016/j.ydbio.2024.12.018
Abstract
The cell nuclei of Ophisthokonts, the eukaryotic supergroup defined by fungi and metazoans, is remarkable in the constancy of their double-membraned structure in both somatic and germ cells. Such remarkable structural conservation underscores common and ancient evolutionary origins. Yet, the dynamics of disassembly and reassembly displayed by Ophisthokont nuclei vary extensively. Besides closed mitosis in fungi and open mitosis in some animals, little is known about the evolution of nuclear envelope remodeling dynamics during oogenesis. Here, we uncovered a novel form of nuclear envelope remodeling as oocytes are formed in the flatworm Schmidtea mediterranea. From zygotene to metaphase II, both nuclear envelope (NE) and peripheral endoplasmic reticulum (ER) expand notably in size, likely involving de novo membrane synthesis. 3-D electron microscopy reconstructions demonstrated that the NE transforms itself into numerous double-membraned vesicles similar in membrane architecture to NE doublets in mammalian oocytes after germinal vesicle breakdown. The vesicles are devoid of nuclear pore complexes and DNA, yet are loaded with nuclear proteins, including a planarian homologue of PIWI, a protein essential for the maintenance of stem cells in this and other organisms. Our data contribute a new model to the canonical view of NE dynamics and suggest important roles of NE remodeling in planarian oogenesis.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Biochemie VI - RNA Biochemie Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Biochemie VI - RNA Biochemie > Lehrstuhl Biochemie VI - RNA Biochemie - Univ.-Prof. Dr. Claus-Dieter Kuhn |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 27 Jan 2025 10:12 |
| Letzte Änderung: | 27 Jan 2025 10:12 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/91696 |