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A radical approach towards polarity-reversed para-substitution of electron-deficient arenes

Title data

Singh, Shashank ; Kundu, Arindam ; Empel, Claire ; Koenigs, Rene M. ; Singh, Ravi P.:
A radical approach towards polarity-reversed para-substitution of electron-deficient arenes.
In: Chemical Communications. Vol. 61 (2025) . - pp. 3888-3891.
ISSN 1364-548X
DOI: https://doi.org/10.1039/D4CC04914D

Abstract in another language

We have developed a protocol for polarity-reversed para-substitution of electron-deficient arenes. In order to achieve desired reactivity and selectivity for a broad range of substrates, the dual pronged strategy is essential. Furthermore, this approach has also shown promise in perfluoroalkylation of arenes. Control experiments and computational studies provide a mechanistic insight for the observed selectivity. The potential for drug design synthesis has been showcased by this economical and ecofriendly method that provides access to a variety of building blocks.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 28 Mar 2025 07:29
Last Modified: 28 Mar 2025 07:29
URI: https://eref.uni-bayreuth.de/id/eprint/93015