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Cai, Bao-Gui ; Empel, Claire ; Jana, Sripati ; Xuan, Jun ; Koenigs, Rene M.:
Catalytic Olefin Cyclopropanation with In Situ-Generated Dialkyl Diazomethanes via Co(II)-Based Metalloradical Catalysis.
In: ACS Catalysis.
Bd. 13
(2023)
.
- S. 11851-11856.
ISSN 2155-5435
DOI: https://doi.org/10.1021/acscatal.3c02468
Abstract
The synthesis of dialkyl-substituted cyclopropanes is an important challenge in synthesis with applications in drug discovery and agrochemistry. Herein, we report on the synthesis of gem-dialkyl cyclopropanes with in situ-generated dialkyl diazo compounds under Bamford–Stevens conditions. A simple cobalt catalyst was identified to be optimal to achieve high yields. Experimental and computational studies suggest the participation of a metalloradical reaction mechanism that facilitates the carbene transfer reactions and provides access to dialkyl-substituted cyclopropanes in a single step.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | carbene transfer; cyclopropanation; radical chemistry; cobalt; computational chemistry |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 28 Mär 2025 10:12 |
| Letzte Änderung: | 28 Mär 2025 10:12 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/93038 |