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Jana, Sripati ; Empel, Claire ; Pei, Chao ; Nguyen, Thanh Vinh ; Koenigs, Rene M.:
Gold‐catalyzed C−H Functionalization of Phenothiazines with Aryldiazoacetates.
In: Advanced Synthesis & Catalysis.
Bd. 362
(2020)
.
- S. 5721-5727.
ISSN 1615-4169
DOI: https://doi.org/10.1002/adsc.202000962
Abstract
Phenothiazine is an important structural motif in pharmaceuticals and advanced functional organic materials. However, the C−H functionalization reaction of N-protected phenothiazine is rather unexplored and often shadowed by its chemical reactivity on the heteroatomic centers, which limits the diversity of its potential applications. This report demonstrates a straightforward approach towards the site-selective C−H functionalization of phenothiazine at the para-position of N atom via gold-catalyzed carbene transfer reactions (37 examples, up to 83% yield). The mechanism behind the regionselectivity of the C−H functionalization reaction was also elucidated by a combination of computational and experimental studies.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 01 Apr 2025 13:10 |
| Letzte Änderung: | 01 Apr 2025 13:10 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/93128 |