Title data
Kitana, Waseem ; Apsite, Indra ; Ionov, Leonid:
3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications : Possibilities and Limitations.
In: Advanced Functional Materials.
(14 April 2025)
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- 2500450.
ISSN 1616-3028
DOI: https://doi.org/10.1002/adfm.202500450
Project information
Project financing: |
Deutsche Forschungsgemeinschaft DFG IO 68/14-1, 68/14-2, and 326998133 – TRR 225 subproject A08. |
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Abstract in another language
Biofabrication is an emerging interdisciplinary field of engineering that aims to develop technologies for applications in tissue engineering and regenerative medicine. A progressing biofabrication technology is 3D (bio) printing (3DBP), which allows for controlled spatial deposition of cell-laden bioinks in a layer-by-layer approach to fabricate biologically active constructs. Although 3DBP can create some biologically relevant structures, it uses hydrogels, which are isotropic in nature and do not provide sufficient mechanical properties to reconstruct many tissues, such as cartilage, bone, and skin. Additionally, hydrogels alone do not replicate the complex hierarchical buildup of native tissue extracellular matrix (ECM), which contains both gel-like and fibrous components. Replicating native tissue's structure both mechanically and biologically by incorporating fibers would result in enhanced biological performance. This is possible by integrating biofabrication technologies such as 3DBP and fiber fabrication techniques. Thus, harnessing the strengths of each technique and eliminating their limitations. This will enable the fabrication of hybrid 3D constructs with multiscale hierarchy and enhanced mechanical and biological performance comparable to native tissue. This review aims to highlight attempts to combine fiber fabrication methods with 3DBP for tissue engineering applications. Additionally, different fiber fabrication techniques are discussed, showcasing their limitations and possible integration with 3DBP.
Further data
Item Type: | Article in a journal |
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Refereed: | No |
Institutions of the University: | Faculties > Faculty of Engineering Science > Professor Biofabrication > Professor Biofabrication - Univ.-Prof. Dr. Leonid Ionov |
Result of work at the UBT: | Yes |
DDC Subjects: | 500 Science > 570 Life sciences, biology 600 Technology, medicine, applied sciences > 600 Technology 600 Technology, medicine, applied sciences > 610 Medicine and health 600 Technology, medicine, applied sciences > 620 Engineering 600 Technology, medicine, applied sciences > 670 Manufacturing |
Date Deposited: | 16 Apr 2025 06:40 |
Last Modified: | 16 Apr 2025 06:40 |
URI: | https://eref.uni-bayreuth.de/id/eprint/93308 |