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Pradhan, Suman ; Hu, Jun ; Ren, Peng ; Qin, Yuman ; Jain, Noopur ; Monti, Susanna ; Barcaro, Giovanni ; Jaworski, Aleksander ; Dai, Xingchao ; Rabeah, Jabor ; Silvestre-Albero, Joaquin ; Celorrio, Veronica ; Rokicińska, Anna ; Kuśtrowski, Piotr ; Van Aert, Sandra ; Bals, Sara ; Das, Shoubhik:
An Atomically Dispersed Photocatalyst for Undirected para‐Selective C–H bond Functionalizations.
In: Angewandte Chemie International Edition.
(2025)
.
- e202508512.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.202508512
Abstract
Regioselective C–H bond functionalization is pivotal in modern scientific exploration, offering solutions for achieving novel synthetic methodologies and pharmaceutical development. In this aspect, achieving exceptional regioselective functionalization, like para-selective products in electron-poor aromatics, diverges from traditional methods. Leveraging the advantages of atomically dispersed photocatalysts, we designed a robust photocatalyst for an unconventional regioselective aromatic C–H bond functionalization. This innovation enabled para-selective trifluoromethylations of electron-deficient meta-directing aromatics (-NO2, -CF3, -CN, etc.), which is entirely orthogonal to the traditional approaches. Mechanistic experiments and DFT analysis confirmed the interaction between Cu-atom and the aromatic substrate, alongside the photocatalyst's molecular arrangement, driving selective exposure of the para-selective functionalization. This strategic approach elucidated pathways for precise molecular transformations, advancing the frontier of regioselective C–H bond functionalization by using atomically dispersed photocatalysts in organic synthesis.
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| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Organische Chemie I - Photo- und Elektrokatalyse für Nachhaltigkeit > Lehrstuhl Organische Chemie I - Photo- und Elektrokatalyse für Nachhaltigkeit - Univ.-Prof. Dr. Shoubhik Das |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 24 Jun 2025 11:22 |
| Letzte Änderung: | 24 Jun 2025 11:22 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/93966 |