Protein Target Highlights in CASP16: Insights From the Structure Providers

Title data

Alexander, Leila T. ; Follonier, Océane M. ; Kryshtafovych, Andriy ; Abesamis, Kim ; Bibi-Triki, Sabrina ; Box, Henry G. ; Breyton, Cécile ; Bringel, Françoise ; Carrique, Loic ; d'Acapito, Alessio ; Dong, Gang ; DuBois, Rebecca ; Fass, Deborah ; Martinez Fiesco, Juliana ; Fox, Daniel R. ; Grimes, Jonathan M. ; Grinter, Rhys ; Jenkins, Matthew ; Kamyshinsky, Roman ; Keown, Jeremy R. ; Lackner, Gerald ; Lammers, Michael ; Liu, Shiheng ; Lovering, Andrew L. ; Malinauskas, Tomas ; Masquida, Benoît ; Palm, Gottfried J. ; Siebold, Christian ; Su, Tiantian ; Zhang, Ping ; Zhou, Z. Hong ; Fidelis, Krzysztof ; Topf, Maya ; Moult, John ; Schwede, Torsten:
Protein Target Highlights in CASP16: Insights From the Structure Providers.
In: Proteins: Structure, Function, and Bioinformatics. (9 October 2025) .
ISSN 1097-0134
DOI: https://doi.org/10.1002/prot.70025

Official URL:

Abstract in another language

This article presents an in-depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions. While the overall performance of structure prediction methods remains impressive, challenges persist, particularly in modeling rare structural motifs, flexible regions, small molecule interactions, posttranslational modifications, and biologically important interfaces. Addressing these limitations can strengthen the role of structure prediction in complementing experimental efforts and advancing both basic research and biomedical applications.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Keywords:	Protein CASP16 targets
Institutions of the University:	Faculties > Faculty of Life Sciences: Food, Nutrition and Health Faculties > Faculty of Life Sciences: Food, Nutrition and Health > Chair Biochemistry of Microorganisms > Chair Biochemistry of Microorganisms - Univ.-Prof. Dr. Gerald Lackner
Result of work at the UBT:	No
DDC Subjects:	500 Science > 500 Natural sciences 500 Science > 540 Chemistry 500 Science > 570 Life sciences, biology
Date Deposited:	24 Oct 2025 09:15
Last Modified:	24 Oct 2025 09:15
URI:	https://eref.uni-bayreuth.de/id/eprint/94958