Institutionen der Universität Bayreuth
Lehrstuhl Biochemie der Mikroorganismen - Univ.-Prof. Dr. Gerald Lackner

Richter, Ingrid ; Hasan, Mahmudul ; Kramer, Johannes W. ; Wein, Philipp ; Krabbe, Jana ; Wojtas, Philip K. ; Stinear, Timothy P. ; Pidot, Sacha J. ; Kloss, Florian ; Hertweck, Christian ; Lackner, Gerald:
Deazaflavin metabolite produced by endosymbiotic bacteria controls fungal host reproduction.
In: The ISME Journal. Bd. 18 (2024) Heft 1 . - wrae074.
DOI: https://doi.org/10.1093/ismejo/wrae074

Ehinger, Friedrich J. ; Niehs, Sarah P. ; Dose, Benjamin ; Dell, Maria ; Krabbe, Jana ; Pidot, Sacha J. ; Stinear, Timothy P. ; Scherlach, Kirstin ; Ross, Claudia ; Lackner, Gerald ; Hertweck, Christian:
Analysis of rhizonin biosynthesis reveals origin of pharmacophoric furylalanine moieties in diverse cyclopeptides.
In: Angewandte Chemie International Edition. Bd. 62 (2023) Heft 42 . - e202308540.
DOI: https://doi.org/10.1002/anie.202308540

Löhr, Nikolai A. ; Rakhmanov, Malik ; Wurlitzer, Jacob M. ; Lackner, Gerald ; Gressler, Markus ; Hoffmeister, Dirk:
Basidiomycete non-reducing polyketide synthases function independently of SAT domains.
In: Fungal Biology and Biotechnology. Bd. 10 (2023) Heft 1 . - 17.
DOI: https://doi.org/10.1186/s40694-023-00164-z

Hasan, Mahmudul ; Schulze, Sabrina ; Berndt, Leona ; Palm, Gottfried J. ; Braga, Daniel ; Richter, Ingrid ; Last, Daniel ; Lammers, Michael ; Lackner, Gerald:
Diversification by CofC and control by CofD govern biosynthesis and evolution of coenzyme F₄₂₀ and its derivative 3PG-F₄₂₀.
In: mBio. Bd. 13 (2022) Heft 1 . - e03501-21.
DOI: https://doi.org/10.1128/mbio.03501-21

Last, Daniel ; Hasan, Mahmudul ; Rothenburger, Linda ; Braga, Daniel ; Lackner, Gerald:
High-yield production of coenzyme F₄₂₀ in Escherichia coli by fluorescence-based screening of multi-dimensional gene expression space.
In: Metabolic Engineering. Bd. 73 (2022) . - S. 158-167.
DOI: https://doi.org/10.1016/j.ymben.2022.07.006

Ellerhorst, Mark ; Barth, Stefanie A. ; Graça, Ana Patrícia ; Al-Jammal, Walid K. ; Peña-Ortiz, Luis ; Vilotijevic, Ivan ; Lackner, Gerald:
S-Adenosylmethionine (SAM)-dependent methyltransferase MftM is responsible for methylation of the redox cofactor mycofactocin.
In: ACS Chemical Biology. Bd. 17 (2022) Heft 11 . - S. 3207-3217.
DOI: https://doi.org/10.1021/acschembio.2c00659

Lackner, Gerald:
Rezension von: Webb, Amy ; Hessel, Andrew: The Genesis Machine: our quest to rewrite life in the age of synthetic biology. New York, 2022.
In: BIOspektrum. Bd. 28 (2022) Heft 7 . - S. 769.
DOI: https://doi.org/10.1007/s12268-022-1867-6

Um, Soohyun ; Guo, Huijuan ; Thiengmag, Sirinthra ; Benndorf, René ; Murphy, Robert ; Rischer, Maja ; Braga, Daniel ; Poulsen, Michael ; de Beer, Z. Wilhelm ; Lackner, Gerald ; Beemelmanns, Christine:
Comparative genomic and metabolic analysis of Streptomyces sp. RB110 morphotypes illuminates genomic rearrangements and formation of a new 46-membered antimicrobial macrolide.
In: ACS Chemical Biology. Bd. 16 (2021) Heft 8 . - S. 1482-1492.
DOI: https://doi.org/10.1021/acschembio.1c00357

Peña-Ortiz, Luis ; Schlembach, Ivan ; Lackner, Gerald ; Regestein, Lars:
Impact of oxygen supply and scale up on Mycobacterium smegmatis cultivation and mycofactocin formation.
In: Frontiers in Bioengineering and Biotechnology. Bd. 8 (2020) . - 593781.
DOI: https://doi.org/10.3389/fbioe.2020.593781

Lenz, Claudius ; Wick, Jonas ; Braga, Daniel ; García‐Altares, María ; Lackner, Gerald ; Hertweck, Christian ; Gressler, Markus ; Hoffmeister, Dirk:
Injury‐triggered blueing reactions of Psilocybe “magic” mushrooms.
In: Angewandte Chemie International Edition. Bd. 59 (2020) Heft 4 . - S. 1450-1454.
DOI: https://doi.org/10.1002/anie.201910175

Braga, Daniel ; Hasan, Mahmudul ; Kröber, Tabea ; Last, Daniel ; Lackner, Gerald:
Redox coenzyme F₄₂₀ biosynthesis in Thermomicrobia involves reduction by stand-alone nitroreductase superfamily enzymes.
In: Applied and Environmental Microbiology. Bd. 86 (2020) Heft 12 .
DOI: https://doi.org/10.1128/AEM.00457-20

Peña-Ortiz, Luis ; Graça, Ana Patrícia ; Guo, Huijuan ; Braga, Daniel ; Köllner, Tobias G. ; Regestein, Lars ; Beemelmanns, Christine ; Lackner, Gerald:
Structure elucidation of the redox cofactor mycofactocin reveals oligo-glycosylation by MftF.
In: Chemical Science. Bd. 11 (2020) Heft 20 . - S. 5182-5190.
DOI: https://doi.org/10.1039/D0SC01172J

Stöckli, Martina ; Morinaka, Brandon I. ; Lackner, Gerald ; Kombrink, Anja ; Sieber, Ramon ; Margot, Céline ; Stanley, Claire E. ; deMello, Andrew J. ; Piel, Jörn ; Künzler, Markus:
Bacteria‐induced production of the antibacterial sesquiterpene lagopodin B in Coprinopsis cinerea.
In: Molecular Microbiology. Bd. 112 (2019) Heft 2 . - S. 605-619.
DOI: https://doi.org/10.1111/mmi.14277

Braga, Daniel ; Last, Daniel ; Hasan, Mahmudul ; Guo, Huijuan ; Leichnitz, Daniel ; Uzum, Zerrin ; Richter, Ingrid ; Schalk, Felix ; Beemelmanns, Christine ; Hertweck, Christian ; Lackner, Gerald:
Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F₄₂₀.
In: ACS Chemical Biology. Bd. 14 (2019) Heft 9 . - S. 2088-2094.
DOI: https://doi.org/10.1021/acschembio.9b00605

Götze, Sebastian ; Arp, Johannes ; Lackner, Gerald ; Zhang, Shuaibing ; Kries, Hajo ; Klapper, Martin ; García-Altares, María ; Willing, Karsten ; Günther, Markus ; Stallforth, Pierre:
Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases.
In: Chemical Science. Bd. 10 (2019) Heft 48 . - S. 10979-10990.
DOI: https://doi.org/10.1039/C9SC03633D

Klapper, Martin ; Braga, Daniel ; Lackner, Gerald ; Herbst, Rosa ; Stallforth, Pierre:
Bacterial alkaloid biosynthesis: structural diversity via a minimalistic nonribosomal peptide synthetase.
In: Cell Chemical Biology. Bd. 25 (2018) Heft 6 . - 659-665.e9.
DOI: https://doi.org/10.1016/j.chembiol.2018.02.013

Brandenburger, Eileen ; Braga, Daniel ; Kombrink, Anja ; Lackner, Gerald ; Gressler, Julia ; Künzler, Markus ; Hoffmeister, Dirk:
Multi-genome analysis identifies functional and phylogenetic diversity of basidiomycete adenylate-forming reductases.
In: Fungal Genetics and Biology. Bd. 112 (2018) . - S. 55-63.
DOI: https://doi.org/10.1016/j.fgb.2016.07.008

Guo, Huijuan ; Schmidt, Alexander ; Stephan, Philipp ; Raguž, Luka ; Braga, Daniel ; Kaiser, Marcel ; Dahse, Hans‐Martin ; Weigel, Christiane ; Lackner, Gerald ; Beemelmanns, Christine:
Precursor‐directed diversification of cyclic tetrapeptidic pseudoxylallemycins.
In: ChemBioChem. Bd. 19 (2018) Heft 21 . - S. 2307-2311.
DOI: https://doi.org/10.1002/cbic.201800503

Brandenburger, Eileen ; Gressler, Markus ; Leonhardt, Robin ; Lackner, Gerald ; Habel, Andreas ; Hertweck, Christian ; Brock, Matthias ; Hoffmeister, Dirk:
A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore.
In: Applied and Environmental Microbiology. Bd. 83 (2017) Heft 21 . - e01478-17.
DOI: https://doi.org/10.1128/AEM.01478-17

Lackner, Gerald ; Peters, Eike Edzard ; Helfrich, Eric J. N. ; Piel, Jörn:
Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 114 (2017) Heft 3 . - E347-E356.
DOI: https://doi.org/10.1073/pnas.1616234114

Braga, Daniel ; Lackner, Gerald:
One ring to fight them all: the sulfazecin story.
In: Cell Chemical Biology. Bd. 24 (2017) Heft 1 . - S. 1-2.
DOI: https://doi.org/10.1016/j.chembiol.2017.01.001

Shah, Firoz ; Nicolás, César ; Bentzer, Johan ; Ellström, Magnus ; Smits, Mark ; Rineau, Francois ; Canbäck, Björn ; Floudas, Dimitrios ; Carleer, Robert ; Lackner, Gerald ; Braesel, Jana ; Hoffmeister, Dirk ; Henrissat, Bernard ; Ahrén, Dag ; Johansson, Tomas ; Hibbett, David S. ; Martin, Francis ; Persson, Per ; Tunlid, Anders:
Ectomycorrhizal fungi decompose soil organic matter using oxidative mechanisms adapted from saprotrophic ancestors.
In: New Phytologist. Bd. 209 (2016) Heft 4 . - S. 1705-1719.
DOI: https://doi.org/10.1111/nph.13722

Wick, Jonas ; Heine, Daniel ; Lackner, Gerald ; Misiek, Mathias ; Tauber, James ; Jagusch, Hans ; Hertweck, Christian ; Hoffmeister, Dirk:
A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (Honey Mushroom) toxins.
In: Applied and Environmental Microbiology. Bd. 82 (2016) Heft 4 . - S. 1196-1204.
DOI: https://doi.org/10.1128/AEM.03168-15

Fuchs, Sebastian W. ; Lackner, Gerald ; Morinaka, Brandon I. ; Morishita, Yohei ; Asai, Teigo ; Riniker, Sereina ; Piel, Jörn:
A lanthipeptide‐like N‐terminal leader region guides peptide epimerization by Radical SAM epimerases: implications for RiPP evolution.
In: Angewandte Chemie International Edition. Bd. 55 (2016) Heft 40 . - S. 12330-12333.
DOI: https://doi.org/10.1002/anie.201602863

Kalb, Daniel ; Lackner, Gerald ; Rappe, Marcus ; Hoffmeister, Dirk:
Activity of α‐aminoadipate reductase depends on the N‐terminally extending domain.
In: ChemBioChem. Bd. 16 (2015) Heft 10 . - S. 1426-1430.
DOI: https://doi.org/10.1002/cbic.201500190

Kalb, Daniel ; Heinekamp, Thorsten ; Lackner, Gerald ; Scharf, Daniel H. ; Dahse, Hans-Martin ; Brakhage, Axel A. ; Hoffmeister, Dirk:
Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus.
In: Applied and Environmental Microbiology. Bd. 81 (2015) Heft 5 . - S. 1594-1600.
DOI: https://doi.org/10.1128/AEM.03268-14

Graupner, Katharina ; Lackner, Gerald ; Hertweck, Christian:
Genome sequence of mushroom soft-rot pathogen Janthinobacterium agaricidamnosum.
In: Genome Announcements. Bd. 3 (2015) Heft 2 . - e00277-15.
DOI: https://doi.org/10.1128/genomeA.00277-15

Karlsson, Magnus ; Brandström Durling, Mikael ; Choi, Jaeyoung ; Kosawang, Chatchai ; Lackner, Gerald ; Tzelepis, Georgios D. ; Nygren, Kristiina ; Dubey, Mukesh K. ; Kamou, Nathalie ; Levasseur, Anthony ; Zapparata, Antonio ; Wang, Jinhui ; Amby, Daniel Buchvaldt ; Jensen, Birgit ; Sarrocco, Sabrina ; Panteris, Emmanuel ; Lagopodi, Anastasia L. ; Pöggeler, Stefanie ; Vannacci, Giovanni ; Collinge, David B. ; Hoffmeister, Dirk ; Henrissat, Bernard ; Lee, Yong-Hwan ; Jensen, Dan Funck:
Insights on the evolution of mycoparasitism from the genome of Clonostachys rosea.
In: Genome Biology and Evolution. Bd. 7 (2015) Heft 2 . - S. 465-480.
DOI: https://doi.org/10.1093/gbe/evu292

Uzum, Zerrin ; Silipo, Alba ; Lackner, Gerald ; De Felice, Antonia ; Molinaro, Antonio ; Hertweck, Christian:
Structure, genetics and function of an exopolysaccharide produced by a bacterium living within fungal hyphae.
In: ChemBioChem. Bd. 16 (2015) Heft 3 . - S. 387-392.
DOI: https://doi.org/10.1002/cbic.201402488

Moebius, Nadine ; Üzüm, Zerrin ; Dijksterhuis, Jan ; Lackner, Gerald ; Hertweck, Christian:
Active invasion of bacteria into living fungal cells.
In: eLife. Bd. 3 (2014) . - e03007.
DOI: https://doi.org/10.7554/eLife.03007

Hori, Chiaki ; Ishida, Takuya ; Igarashi, Kiyohiko ; Samejima, Masahiro ; Suzuki, Hitoshi ; Master, Emma ; Ferreira, Patricia ; Ruiz-Dueñas, Francisco J. ; Held, Benjamin ; Canessa, Paulo ; Larrondo, Luis F. ; Schmoll, Monika ; Druzhinina, Irina S. ; Kubicek, Christian P. ; Gaskell, Jill A. ; Kersten, Phil ; St. John, Franz ; Glasner, Jeremy ; Sabat, Grzegorz ; Splinter BonDurant, Sandra ; Syed, Khajamohiddin ; Yadav, Jagjit ; Mgbeahuruike, Anthony C. ; Kovalchuk, Andriy ; Asiegbu, Fred O. ; Lackner, Gerald ; Hoffmeister, Dirk ; Rencoret, Jorge ; Gutiérrez, Ana ; Sun, Hui ; Lindquist, Erika ; Barry, Kerrie ; Riley, Robert ; Grigoriev, Igor V. ; Henrissat, Bernard ; Kües, Ursula ; Berka, Randy M. ; Martínez, Angel T. ; Covert, Sarah F. ; Blanchette, Robert A. ; Cullen, Daniel:
Analysis of the Phlebiopsis gigantea genome, transcriptome and secretome provides insight into its pioneer colonization strategies of wood.
In: PLoS Genetics. Bd. 10 (2014) Heft 12 . - e1004759.
DOI: https://doi.org/10.1371/journal.pgen.1004759

Chankhamjon, Pranatchareeya ; Boettger-Schmidt, Daniela ; Scherlach, Kirstin ; Urbansky, Barbara ; Lackner, Gerald ; Kalb, Daniel ; Dahse, Hans-Martin ; Hoffmeister, Dirk ; Hertweck, Christian:
Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion.
In: Angewandte Chemie International Edition. Bd. 53 (2014) Heft 49 . - S. 13409-13413.
DOI: https://doi.org/10.1002/anie.201407624

Kalb, Daniel ; Lackner, Gerald ; Hoffmeister, Dirk:
Functional and phylogenetic divergence of fungal adenylate-forming reductases.
In: Applied and Environmental Microbiology. Bd. 80 (2014) Heft 19 . - S. 6175-6183.
DOI: https://doi.org/10.1128/AEM.01767-14

Lackner, Gerald ; Bohnert, Markus ; Wick, Jonas ; Hoffmeister, Dirk:
Assembly of melleolide antibiotics involves a polyketide synthase with cross-coupling activity.
In: Chemistry & Biology. Bd. 20 (2013) Heft 9 . - S. 1101-1106.
DOI: https://doi.org/10.1016/j.chembiol.2013.07.009

Steinchen, Wieland ; Lackner, Gerald ; Yasmin, Sabiha ; Schrettl, Markus ; Dahse, Hans-Martin ; Haas, Hubertus ; Hoffmeister, Dirk:
Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen aspergillus fumigatus.
In: Applied and Environmental Microbiology. Bd. 79 (2013) Heft 21 . - S. 6670-6676.
DOI: https://doi.org/10.1128/AEM.02642-13

Scherlach, Kirstin ; Lackner, Gerald ; Graupner, Katharina ; Pidot, Sacha ; Bretschneider, Tom ; Hertweck, Christian:
Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease.
In: ChemBioChem. Bd. 14 (2013) Heft 18 . - S. 2439-2443.
DOI: https://doi.org/10.1002/cbic.201300553

Kalb, Daniel ; Lackner, Gerald ; Hoffmeister, Dirk:
Fungal peptide synthetases: an update on functions and specificity signatures.
In: Fungal Biology Reviews. Bd. 27 (2013) Heft 2 . - S. 43-50.
DOI: https://doi.org/10.1016/j.fbr.2013.05.002

Wackler, Barbara ; Lackner, Gerald ; Chooi, Yit Heng ; Hoffmeister, Dirk:
Characterization of the Suillus grevillei quinone synthetase GreA supports a nonribosomal code for aromatic α‐keto acids.
In: ChemBioChem. Bd. 13 (2012) Heft 12 . - S. 1798-1804.
DOI: https://doi.org/10.1002/cbic.201200187

Lackner, Gerald ; Misiek, Mathias ; Braesel, Jana ; Hoffmeister, Dirk:
Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases.
In: Fungal Genetics and Biology. Bd. 49 (2012) Heft 12 . - S. 996-1003.
DOI: https://doi.org/10.1016/j.fgb.2012.09.009

Graupner, Katharina ; Scherlach, Kirstin ; Bretschneider, Tom ; Lackner, Gerald ; Roth, Martin ; Gross, Harald ; Hertweck, Christian:
Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen.
In: Angewandte Chemie International Edition. Bd. 51 (2012) Heft 52 . - S. 13173-13177.
DOI: https://doi.org/10.1002/anie.201206658

Bretschneider, Tom ; Graupner, Katharina ; Hertweck, Christian ; Lackner, Gerald ; Scherlach, Kirstin:
Jagaricin, derivatives, and uses thereof.
EP2703410A1 (2012)

Silipo, Alba ; Leone, Maria R. ; Lanzetta, Rosa ; Parrilli, Michelangelo ; Lackner, Gerald ; Busch, Benjamin ; Hertweck, Christian ; Molinaro, Antonio:
Structural characterization of two lipopolysaccharide O-antigens produced by the endofungal bacterium Burkholderia sp. HKI-402 (B4).
In: Carbohydrate Research. Bd. 347 (2012) Heft 1 . - S. 95-98.
DOI: https://doi.org/10.1016/j.carres.2011.10.038

Scherlach, Kirstin ; Busch, Benjamin ; Lackner, Gerald ; Paszkowski, Uta ; Hertweck, Christian:
Symbiotic cooperation in the biosynthesis of a phytotoxin.
In: Angewandte Chemie International Edition. Bd. 51 (2012) Heft 38 . - S. 9615-9618.
DOI: https://doi.org/10.1002/anie.201204540

Gee, Jay E. ; Glass, Mindy B. ; Lackner, Gerald ; Helsel, Leta O. ; Daneshvar, Maryam ; Hollis, Dannie G. ; Jordan, Jean ; Morey, Roger ; Steigerwalt, Arnold ; Hertweck, Christian:
Characterization of Burkholderia rhizoxinica and B. endofungorum isolated from clinical specimens.
In: PLoS One. Bd. 6 (2011) Heft 1 . - e15731.
DOI: https://doi.org/10.1371/journal.pone.0015731

Lackner, Gerald ; Moebius, Nadine ; Partida-Martinez, Laila ; Hertweck, Christian:
Complete genome sequence of Burkholderia rhizoxinica, an endosymbiont of Rhizopus microsporus.
In: Journal of Bacteriology. Bd. 193 (2011) Heft 3 . - S. 783-784.
DOI: https://doi.org/10.1128/JB.01318-10

Lackner, Gerald ; Moebius, Nadine ; Hertweck, Christian:
Endofungal bacterium controls its host by an hrp type III secretion system.
In: The ISME Journal. Bd. 5 (2011) Heft 2 . - S. 252-261.
DOI: https://doi.org/10.1038/ismej.2010.126

Lackner, Gerald ; Moebius, Nadine ; Partida-Martinez, Laila P. ; Boland, Sebastian ; Hertweck, Christian:
Evolution of an endofungal lifestyle: deductions from the Burkholderia rhizoxinica genome.
In: BMC Genomics. Bd. 12 (2011) Heft 1 . - 210.
DOI: https://doi.org/10.1186/1471-2164-12-210

Lackner, Gerald ; Hertweck, Christian:
Impact of endofungal bacteria on infection biology, food safety, and drug development.
In: PLoS Pathogens. Bd. 7 (2011) Heft 6 . - e1002096.
DOI: https://doi.org/10.1371/journal.ppat.1002096

Leone, Maria R. ; Lackner, Gerald ; Silipo, Alba ; Lanzetta, Rosa ; Molinaro, Antonio ; Hertweck, Christian:
An unusual galactofuranose lipopolysaccharide that ensures the intracellular survival of toxin‐producing bacteria in their fungal host.
In: Angewandte Chemie International Edition. Bd. 49 (2010) Heft 41 . - S. 7476-7480.
DOI: https://doi.org/10.1002/anie.201003301

Lackner, Gerald ; Partida-Martinez, Laila P. ; Hertweck, Christian:
Endofungal bacteria as producers of mycotoxins.
In: Trends in Microbiology. Bd. 17 (2009) Heft 12 . - S. 570-576.
DOI: https://doi.org/10.1016/j.tim.2009.09.003

Lackner, Gerald ; Möbius, Nadine ; Scherlach, Kirstin ; Partida-Martinez, Laila P. ; Winkler, Robert ; Schmitt, Imke ; Hertweck, Christian:
Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis.
In: Applied and Environmental Microbiology. Bd. 75 (2009) Heft 9 . - S. 2982-2986.
DOI: https://doi.org/10.1128/AEM.01765-08

Lackner, Gerald ; Schenk, Angéla ; Xu, Zhongli ; Reinhardt, Kathrin ; Yunt, Zeynep S. ; Piel, Jörn ; Hertweck, Christian:
Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways.
In: Journal of the American Chemical Society. Bd. 129 (2007) Heft 30 . - S. 9306-9312.
DOI: https://doi.org/10.1021/ja0718624