Novel 'Nano in Nano' Composites for Sustained Drug Delivery : Biodegradable Nanoparticles Encapsulated into Nanofiber Non-Wovens

Title data

Beck-Broichsitter, Moritz ; Thieme, Marcel ; Nguyen, Juliane ; Schmehl, Thomas ; Gessler, Tobias ; Seeger, Werner ; Agarwal, Seema ; Greiner, Andreas ; Kissel, Thomas:
Novel 'Nano in Nano' Composites for Sustained Drug Delivery : Biodegradable Nanoparticles Encapsulated into Nanofiber Non-Wovens.
In: Macromolecular Bioscience. Vol. 10 (2010) Issue 12 . - pp. 1527-1535.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.201000100

Project information

Abstract in another language

Novel 'nano in nano' composites consisting of biodegradable polymer nanoparticles incorporated into polymer nanofibers may efficiently modulate drug delivery. This is shown here using a combination of model compound-loaded biodegradable nanoparticles encapsulated in electrospun fibers. The dye coumarin 6 is used as model compound for a drug in order to simulate drug release from loaded poly(lactide-co-glycolide) nanoparticles. Dye release from the nanoparticles occurs immediately in aqueous solution. Dye-loaded nanoparticles which are encapsulated by electrospun polymer nanofibers display a significantly retarded release.