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Ai, Hui-wang ; Arnold, Frances H. ; Barrick, Doug ; Bayley, Hagan ; Brownless, Alfie-Louise R. ; Campbell, Robert E. ; Castells-Graells, Roger ; Chaiyen, Pimchai ; Chica, Roberto A. ; Chisholm, Lauren O. ; Christ, Daniel ; Chu, Guo-Chao ; Chungyoun, Michael ; Eijsink, Vincent G. H. ; Elowitz, Michael B. ; Fansher, Douglas J. ; Fasan, Rudi ; Foley, Gabriel ; Frei, Michelle S. ; Gagsteiger, Andreas ; Gao, Ruiyan ; Gillam, Elizabeth M. J. ; Gray, Jeffrey J. ; Guerra, Luis F. ; Höcker, Birte ; Jin, Zhiyang ; Kamerlin, Shina Caroline Lynn ; Koga, Nobuyasu ; Kontermann, Roland E. ; Kuhlman, Brian ; Langlois, Olivia A. ; Li, Dongyang ; Lins, Roberto D. ; Liu, Chang C. ; Liu, Lei ; López Barreiro, Diego ; Lu, Peilong ; Mehta, Sohum ; Miyazaki, Ikumi ; Müller, Manuel M. ; Muyldermans, Serge ; Nemoto, Naoto ; Nivala, Jeff ; Nuñez, James K. ; Ornelas, Izaiah J. ; Pelletier, Joelle N. ; Plückthun, Andreas ; Porth, Owen T. ; Prakinee, Kridsadakorn ; Qing, Yujia ; Reisenbauer, Julia C. ; Schmidt, Sandy ; Seifert, Oliver ; Shapiro, Mikhail G. ; Sharma, Rachna ; Singh, Nilmani ; Smith, Benjamin J. ; Spangler, Jamie B. ; Tatsumi-Koga, Rie ; Terai, Takuya ; Terholsen, Henrik ; Tolhurst, Mattias ; Tripp, Katherine W. ; Trossmann, Vanessa T. ; Tucker, Chandra L. ; Turak, Onur ; Van Deventer, James A. ; Várnai, Anikó ; Viana, Isabelle F. T. ; Weeks, Amy M. ; Wittrup, K. Dane ; Wong, Kingsley L.-J. ; Xi, Chenggang ; Yeates, Todd O. ; Yeh, Andy Hsien-Wei ; Zhang, Jin ; Zhang, Tiger S. ; Zhao, Huimin ; Zheng, Fang ; Zhu, Jingyi ; Zinn, Sacha:
Protein engineering : Status report.
In: Protein Engineering, Design & Selection.
(17 July 2026)
.
- gzag020.
ISSN 1741-0134
DOI: https://doi.org/10.1093/protein/gzag020
Project information
| Project title: |
Project's official title Project's id SFB 1357: MIKROPLASTIK – Gesetzmäßigkeiten der Bildung, des Transports, des physikalisch-chemischen Verhaltens sowie der biologischen Effekte: Von Modell- zu komplexen Systemen als Grundlage neuer Lösungsansätze 391977956 ERC Synergy Grant ArtMotor "Grant Agreement No 951375" 951375 |
|---|---|
| Project financing: |
Deutsche Forschungsgemeinschaft ERC_Starting Grant - Metamech |
Abstract in another language
With this status report, we aim to provide a timely snapshot of the protein engineering field as a broad and rapidly advancing discipline that integrates computational, molecular biology, structure-guided, evolutionary, and synthetic approaches to create new and improved proteins with tailored structures and useful functions. The report is organized into eight thematic areas spanning core methodologies and major application domains, including enzymes, therapeutics, detection, synthetic biology, and materials. Contributions from experts across these areas highlight both the historical foundations and recent advances in their respective fields, with particular emphasis on the growing influence of machine learning and artificial intelligence-based methods. Emerging from this broad overview is a central message: protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain. Looking ahead, the continued integration of computational and experimental strategies is poised to further accelerate the impact of protein engineering across an expanding range of economically and societally important sectors, from therapeutics and molecular imaging to diagnostics, plastic recycling, and industrial chemistry.