Institutions of the University of Bayreuth
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Birte Höcker

Romero-Romero, Sergio ; Kordes, Sina ; Michel, Florian ; Höcker, Birte:
Evolution, folding, and design of TIM barrels and related proteins.
In: Current Opinion in Structural Biology. Vol. 68 (June 2021) . - pp. 94-104.
DOI: https://doi.org/10.1016/j.sbi.2020.12.007

Wiese, Jonas Gregor ; Shanmugaratnam, Sooruban ; Höcker, Birte:
Extension of a de novo TIM barrel with a rationally designed secondary structure element.
In: Protein Science. Vol. 30 (May 2021) Issue 5 . - pp. 982-989.
DOI: https://doi.org/10.1002/pro.4064

Herud-Sikimić, Ole ; Stiel, Andre C. ; Kolb, Martina ; Shanmugaratnam, Sooruban ; Berendzen, Kenneth W. ; Feldhaus, Christian ; Höcker, Birte ; Jürgens, Gerd:
A biosensor for the direct visualization of auxin.
In: Nature. Vol. 592 (29 April 2021) Issue 7856 . - pp. 768-772.
DOI: https://doi.org/10.1038/s41586-021-03425-2

Linke, Heiner ; Höcker, Birte ; Furuta, Ken'ya ; Forde, Nancy R. ; Curmi, Paul M. G.:
Synthetic biology approaches to dissecting linear motor protein function : towards the design and synthesis of artificial autonomous protein walkers.
In: Biophysical Reviews. Vol. 12 (August 2020) Issue 4 . - pp. 1041-1054.
DOI: https://doi.org/10.1007/s12551-020-00717-1

Ferruz, Noelia ; Lobos, Francisco ; Lemm, Dominik ; Toledo-Patiño, Saacnicteh ; Farías-Rico, José Arcadio ; Schmidt, Steffen ; Höcker, Birte:
Identification and Analysis of Natural Building Blocks for Evolution-Guided Fragment-Based Protein Design.
In: Journal of Molecular Biology. Vol. 432 (12 June 2020) Issue 13 . - pp. 3898-3914.
DOI: https://doi.org/10.1016/j.jmb.2020.04.013

Toledo-Patiño, Saacnicteh ; Chaubey, Manish ; Coles, Murray ; Höcker, Birte:
Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor.
In: Biochemistry. Vol. 58 (December 2019) Issue 48 . - pp. 4790-4793.
DOI: https://doi.org/10.1021/acs.biochem.9b00900

You, Weijie:
Activation and inhibition of Sirt6 by small molecules.
Bayreuth , 2019 . - 120 p.
( Doctoral thesis, 2019 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00004450

Lechner, Horst ; Ferruz, Noelia ; Höcker, Birte:
Strategies for designing non-natural enzymes and binders.
In: Current Opinion in Chemical Biology. Vol. 47 (December 2018) . - pp. 67-76.
DOI: https://doi.org/10.1016/j.cbpa.2018.07.022

Lichtenstein, Bruce R. ; Höcker, Birte:
Engineering an AB₅ Protein Carrier.
In: Scientific Reports. Vol. 2018 (23 August 2018) Issue 8 . - No. 12643.
DOI: https://doi.org/10.1038/s41598-018-30910-y

Banda-Vázquez, Jesús ; Shanmugaratnam, Sooruban ; Rodríguez-Sotres, Rogelio ; Torres-Larios, Alfredo ; Höcker, Birte ; Sosa-Peinado, Alejandro:
Redesign of LAOBP to bind novel l-amino acid ligands.
In: Protein Science. Vol. 27 (May 2018) Issue 5 . - pp. 957-968.
DOI: https://doi.org/10.1002/pro.3403

Höcker, Birte ; Winther, Jakob R.:
Editorial overview : A perspective on protein evolution.
In: Current Opinion in Structural Biology. Vol. 48 (February 2018) . - S. viii-ix.
DOI: https://doi.org/10.1016/j.sbi.2018.01.013

Sterner, Reinhard ; Höcker, Birte ; Kolmar, Harald:
Highlight issue: protein design.
In: Biological Chemistry. Vol. 398 (1 January 2017) Issue 1 . - pp. 1-2.
DOI: https://doi.org/10.1515/hsz-2016-0322

Toledo-Patiño, Saacnicteh ; Lobos, Francisco ; Höcker, Birte:
Baukasten der Natur : Neue Proteine aus konservierten Fragmenten.
In: BIOspektrum. Vol. 23 (2017) Issue 6 . - pp. 630-633.
DOI: https://doi.org/10.1007/s12268-017-0847-8

Huang, Po-Ssu ; Feldmeier, Kaspar ; Parmeggiani, Fabio ; Velasco, D Alejandro Fernandez ; Höcker, Birte ; Baker, David:
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy.
In: Nature Chemical Biology. Vol. 12 (January 2016) Issue 1 . - pp. 29-34.
DOI: https://doi.org/10.1038/nchembio.1966

Stiel, André C. ; Nellen, Mehdi ; Höcker, Birte:
PocketOptimizer and the Design of Ligand Binding Sites.
In: Stoddard, Barry L. (ed.): Computational Design of Ligand Binding Proteins. - New York : Humana Press, 2016 . - pp. 63-75 . - (Methods in Molecular Biology ; 1414 )
DOI: https://doi.org/10.1007/978-1-4939-3569-7_5

Farías-Rico, José Arcadio ; Schmidt, Steffen ; Höcker, Birte:
Evolutionary relationship of two ancient protein superfolds.
In: Nature Chemical Biology. Vol. 10 (September 2014) Issue 9 . - pp. 710-715.
DOI: https://doi.org/10.1038/nchembio.1579

Höcker, Birte:
Design of proteins from smaller fragments : learning from evolution.
In: Current Opinion in Structural Biology. Vol. 27 (August 2014) . - pp. 56-62.
DOI: https://doi.org/10.1016/j.sbi.2014.04.007

Scheib, Ulrike ; Shanmugaratnam, Sooruban ; Farías-Rico, José Arcadio ; Höcker, Birte:
Change in protein-ligand specificity through binding pocket grafting.
In: Journal of Structural Biology. Vol. 185 (February 2014) Issue 2 . - pp. 186-192.
DOI: https://doi.org/10.1016/j.jsb.2013.06.002

Höcker, Birte ; Midelfort, Katarina:
Designing protein function : macromolecular design.
In: Journal of Structural Biology. Vol. 185 (February 2014) Issue 2 . - p. 135.
DOI: https://doi.org/10.1016/j.jsb.2014.01.011

Stiel, André C. ; Feldmeier, Kaspar ; Höcker, Birte:
Identification of protein scaffolds for enzyme design using scaffold selection.
In: Methods in Molecular Biology. Vol. 1216 (2014) . - pp. 183-196.
DOI: https://doi.org/10.1007/978-1-4939-1486-9_9

Feldmeier, Kaspar ; Höcker, Birte:
Computational protein design of ligand binding and catalysis.
In: Current Opinion in Chemical Biology. Vol. 17 (December 2013) Issue 6 . - pp. 929-933.
DOI: https://doi.org/10.1016/j.cbpa.2013.10.002

Höcker, Birte:
Engineering chimaeric proteins from fold fragments : "hopeful monsters" in protein design.
In: Biochemical Society Transactions. Vol. 41 (October 2013) Issue 5 . - pp. 1137-1140.
DOI: https://doi.org/10.1042/BST20130099

Meier, Monika M. ; Rajendran, Chitra ; Malisi, Christoph ; Fox, Nicholas G. ; Xu, Chengfu ; Schlee, Sandra ; Barondeau, David P. ; Höcker, Birte ; Sterner, Reinhard ; Raushel, Frank M.:
Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template.
In: Journal of the American Chemical Society. Vol. 135 (7 August 2013) Issue 31 . - pp. 11670-11677.
DOI: https://doi.org/10.1021/ja405911h

Farías-Rico, José Arcadio ; Höcker, Birte:
Design of chimeric proteins by combination of subdomain-sized fragments.
In: Methods in Enzymology. Vol. 523 (2013) . - pp. 389-405.
DOI: https://doi.org/10.1016/B978-0-12-394292-0.00018-7

Höcker, Birte:
Structural biology : A toolbox for protein design.
In: Nature. Vol. 491 (8 November 2012) Issue 7423 . - pp. 204-205.
DOI: https://doi.org/10.1038/491204a

Shanmugaratnam, Sooruban ; Eisenbeis, Simone ; Höcker, Birte:
A highly stable protein chimera built from fragments of different folds.
In: Protein Engineering, Design & Selection. Vol. 25 (November 2012) Issue 11 . - pp. 699-703.
DOI: https://doi.org/10.1093/protein/gzs074

Eisenbeis, Simone ; Proffitt, William ; Coles, Murray ; Truffault, Vincent ; Shanmugaratnam, Sooruban ; Meiler, Jens ; Höcker, Birte:
Potential of fragment recombination for rational design of proteins.
In: Journal of the American Chemical Society. Vol. 134 (7 March 2012) Issue 9 . - pp. 4019-4022.
DOI: https://doi.org/10.1021/ja211657k

Höcker, Birte:
Protein design : A metalloenzyme reloaded.
In: Nature Chemical Biology. Vol. 8 (15 February 2012) Issue 3 . - pp. 224-225.
DOI: https://doi.org/10.1038/nchembio.800

Malisi, Christoph ; Schumann, Marcel ; Toussaint, Nora C ; Kageyama, Jorge ; Kohlbacher, Oliver ; Höcker, Birte:
Binding pocket optimization by computational protein design.
In: PLoS One. Vol. 7 (2012) Issue 12 . - No. e52505.
DOI: https://doi.org/10.1371/journal.pone.0052505

Malisi, Christoph ; Stiel, André C. ; Höcker, Birte:
Enzyme am Reißbrett.
In: BIOspektrum. Vol. 17 (2011) Issue 7 . - pp. 736-738.
DOI: https://doi.org/10.1007/s12268-011-0117-0

Eisenbeis, Simone ; Höcker, Birte:
Evolutionary mechanism as a template for protein engineering.
In: Journal of Peptide Science. Vol. 16 (October 2010) Issue 10 . - pp. 538-544.
DOI: https://doi.org/10.1002/psc.1233

Schreier, Bettina ; Höcker, Birte:
Engineering the enolase magnesium II binding site: implications for its evolution.
In: Biochemistry. Vol. 49 (7 September 2010) Issue 35 . - pp. 7582-7589.
DOI: https://doi.org/10.1021/bi100954f

Höcker, Birte:
Metals make proteins stick.
In: Chemistry & Biology. Vol. 17 (26 February 2010) Issue 2 . - pp. 103-104.
DOI: https://doi.org/10.1016/j.chembiol.2010.02.002

Schreier, Bettina ; Stumpp, Christian ; Wiesner, Silke ; Höcker, Birte:
Computational design of ligand binding is not a solved problem.
In: Proceedings of the National Academy of Sciences of the United States of America. Vol. 106 (3 November 2009) Issue 44 . - pp. 18491-18496.
DOI: https://doi.org/10.1073/pnas.0907950106

Malisi, Christoph ; Kohlbacher, Oliver ; Höcker, Birte:
Automated scaffold selection for enzyme design.
In: Proteins. Vol. 77 (October 2009) Issue 1 . - pp. 74-83.
DOI: https://doi.org/10.1002/prot.22418

Claren, Jörg ; Malisi, Christoph ; Höcker, Birte ; Sterner, Reinhard:
Establishing wild-type levels of catalytic activity on natural and artificial (βα)8-barrel protein scaffolds.
In: Proceedings of the National Academy of Sciences of the United States of America. Vol. 106 (10 March 2009) Issue 10 . - pp. 3704-3709.
DOI: https://doi.org/10.1073/pnas.0810342106

Höcker, Birte ; Lochner, Adriane ; Seitz, Tobias ; Claren, Jörg ; Sterner, Reinhard:
High-resolution crystal structure of an artificial (betaalpha)(8)-barrel protein designed from identical half-barrels.
In: Biochemistry. Vol. 48 (17 February 2009) Issue 6 . - pp. 1145-1147.
DOI: https://doi.org/10.1021/bi802125b

Bharat, Tanmay A. M. ; Eisenbeis, Simone ; Zeth, Kornelius ; Höcker, Birte:
A βα-barrel built by the combination of fragments from different folds.
In: Proceedings of the National Academy of Sciences of the United States of America. Vol. 105 (22 July 2008) Issue 29 . - pp. 9942-9947.
DOI: https://doi.org/10.1073/pnas.0802202105

Reetz, Manfred T. ; Rentzsch, Martin ; Pletsch, Andreas ; Taglieber, Andreas ; Hollmann, Frank ; Mondière, Régis J. G. ; Dickmann, Norbert ; Höcker, Birte ; Cerrone, Simona ; Haeger, Michaela C. ; Sterner, Reinhard:
A robust protein host for anchoring chelating ligands and organocatalysts.
In: ChemBioChem. Vol. 9 (3 March 2008) Issue 4 . - pp. 552-564.
DOI: https://doi.org/10.1002/cbic.200700413

Sterner, Reinhard ; Höcker, Birte:
Catalytic versatility, stability, and evolution of the (betaalpha)8-barrel enzyme fold.
In: Chemical Reviews. Vol. 105 (November 2005) Issue 11 . - pp. 4038-4055.
DOI: https://doi.org/10.1021/cr030191z

Höcker, Birte:
Directed evolution of (betaalpha)(8)-barrel enzymes.
In: Biomolecular Engineering. Vol. 22 (June 2005) Issue 1-3 . - pp. 31-38.
DOI: https://doi.org/10.1016/j.bioeng.2004.09.005

Raasch, Carsten ; Armbrecht, Martin ; Streit, Wolfgang ; Höcker, Birte ; Sträter, Norbert ; Liebl, Wolfgang:
Identification of residues important for NAD+ binding by the Thermotoga maritima alpha-glucosidase AglA, a member of glycoside hydrolase family 4.
In: FEBS Letters. Vol. 517 (24 April 2002) Issue 1-3 . - pp. 267-271.
DOI: https://doi.org/10.1016/S0014-5793(02)02641-8

Höcker, Birte ; Schmidt, Steffen ; Sterner, Reinhard:
A common evolutionary origin of two elementary enzyme folds.
In: FEBS Letters. Vol. 510 (16 January 2002) Issue 3 . - pp. 133-135.
DOI: https://doi.org/10.1016/S0014-5793(01)03232-X

Henn-Sax, Martina ; Höcker, Birte ; Wilmanns, Matthias ; Sterner, Reinhard:
Divergent evolution of (betaalpha)8-barrel enzymes.
In: Biological Chemistry. Vol. 382 (September 2001) Issue 9 . - pp. 1315-1320.
DOI: https://doi.org/10.1515/BC.2001.163

Höcker, Birte ; Jürgens, Catharina ; Wilmanns, Matthias ; Sterner, Reinhard:
Stability, catalytic versatility and evolution of the (betaalpha)(8)-barrel fold.
In: Current Opinion in Biotechnology. Vol. 12 (August 2001) Issue 4 . - pp. 376-381.
DOI: https://doi.org/10.1016/S0958-1669(00)00230-5

Höcker, Birte ; Beismann-Driemeyer, Silke ; Hettwer, Stefan ; Lustig, Ariel ; Sterner, Reinhard:
Dissection of a (betaalpha)8-barrel enzyme into two folded halves.
In: Nature Structural Biology. Vol. 8 (January 2001) Issue 1 . - pp. 32-36.
DOI: https://doi.org/10.1038/83021