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Hall, Rebecca A. ; de Sordi, Luisa ; Maccallum, Donna M. ; Topal, Hüsnü ; Eaton, Rebecca ; Bloor, James W. ; Robinson, Gary K. ; Levin, Lonny R. ; Buck, Jochen ; Wang, Yue ; Gow, Neil A .R. ; Steegborn, Clemens ; Mühlschlegel, Fritz A.:
CO₂ acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
In: PLoS Pathogens.
Bd. 6
(2010)
Heft 11
.
- No. e1001193.
ISSN 1553-7374
DOI: https://doi.org/10.1371/journal.ppat.1001193
Abstract
When colonising host-niches or non-animated medical devices, individual cells of the fungal pathogen Candida albicans expand into significant biomasses. Here we show that within such biomasses, fungal metabolically generated CO(2) acts as a communication molecule promoting the switch from yeast to filamentous growth essential for C. albicans pathology. We find that CO(2)-mediated intra-colony signalling involves the adenylyl cyclase protein (Cyr1p), a multi-sensor recently found to coordinate fungal responses to serum and bacterial peptidoglycan. We further identify Lys 1373 as essential for CO(2)/bicarbonate regulation of Cyr1p. Disruption of the CO(2)/bicarbonate receptor-site interferes selectively with C. albicans filamentation within fungal biomasses. Comparisons between the Drosophila melanogaster infection model and the mouse model of disseminated candidiasis, suggest that metabolic CO(2) sensing may be important for initial colonisation and epithelial invasion. Our results reveal the existence of a gaseous Candida signalling pathway and its molecular mechanism and provide insights into an evolutionary conserved CO(2)-signalling system.
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| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Zusätzliche Informationen: | PubMed-ID: 18596626 |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Biochemie > Lehrstuhl Biochemie I - Proteinbiochemie der Signaltransduktion - Univ.-Prof. Dr. Clemens Steegborn Fakultäten Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Biochemie |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 17 Apr 2015 09:18 |
| Letzte Änderung: | 01 Sep 2022 10:55 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/10376 |