Institutionen der Universität Bayreuth
Lehrstuhl Biochemie I - Proteinbiochemie der Signaltransduktion - Univ.-Prof. Dr. Clemens Steegborn

Sun, Shan ; Fushimi, Makoto ; Rossetti, Thomas ; Kaur, Navpreet ; Ferreira, Jacob ; Miller, Michael ; Quast, Jonathan ; van den Heuvel, Joop ; Steegborn, Clemens ; Levin, Lonny R. ; Buck, Jochen ; Myers, Robert W. ; Kargman, Stacia ; Liverton, Nigel ; Meinke, Peter T. ; Huggins, David J.:
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".
In: Journal of Chemical Information and Modeling. Bd. 64 (2024) Heft 3 . - S. 1106.
DOI: https://doi.org/10.1021/acs.jcim.4c00068

You, Weijie ; Montoya, Alba L. ; Dana, Srikanta ; Franzini, Raphael M. ; Steegborn, Clemens:
Elucidating the Unconventional Binding Mode of a DNA‐Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development.
In: ChemMedChem. (2024) . - e202400273.
DOI: https://doi.org/10.1002/cmdc.202400273

Wang, Jinping ; Luo, Jinque ; Rotili, Dante ; Mai, Antonello ; Steegborn, Clemens ; Xu, Suowen ; Jin, Zheng Gen:
SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells.
In: Inflammation. Bd. 47 (2024) . - S. 323-332.
DOI: https://doi.org/10.1007/s10753-023-01911-5

Pannek, Martin ; Alhalabi, Zayan ; Tomaselli, Daniela ; Menna, Martina ; Fiorentino, Francesco ; Robaa, Dina ; Weyand, Michael ; Puhlmann, Maximilian ; Tomassi, Stefano ; Barreca, Federica ; Tafani, Marco ; Zaganjor, Elma ; Haigis, Marcia C. ; Sippl, Wolfgang ; Rotili, Dante ; Mai, Antonello ; Steegborn, Clemens:
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.
In: Journal of Medicinal Chemistry. Bd. 67 (2024) Heft 3 . - S. 1843-1860.
DOI: https://doi.org/10.1021/acs.jmedchem.3c01496

Adolph, Ramona S.:
Biochemical and structural characterization of the regulation of human Sirtuin 1 by small molecules and proteins.
Bayreuth , 2023 . - XIV, 192 S.
( Dissertation, 2020 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00005024

Suenkel, Benjamin:
Bioanalytical an mechanistical analysis of isoform specific Sirtuin modulation.
Bayreuth , 2023 . - X, 112 S.
( Dissertation, 2016 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00003081

Rossetti, Thomas ; Ferreira, Jacob ; Ghanem, Lubna ; Buck, Hannes ; Steegborn, Clemens ; Myers, Robert W. ; Meinke, Peter T. ; Levin, Lonny R. ; Buck, Jochen:
Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
In: Frontiers in Physiology. Bd. 14 (2023) . - 1163389.
DOI: https://doi.org/10.3389/fphys.2023.1163389

Zwergel, Clemens ; Aventaggiato, Michele ; Garbo, Sabrina ; Di Bello, Elisabetta ; Fassari, Bruno ; Noce, Beatrice ; Castiello, Carola ; Lambona, Chiara ; Barreca, Federica ; Rotili, Dante ; Fioravanti, Rossella ; Schmalz, Thomas ; Weyand, Michael ; Niedermeier, Amelie ; Tripodi, Marco ; Colotti, Gianni ; Steegborn, Clemens ; Battistelli, Cecilia ; Tafani, Marco ; Valente, Sergio ; Mai, Antonello:
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells.
In: Journal of Medicinal Chemistry. Bd. 66 (2023) Heft 14 . - S. 9622-9641.
DOI: https://doi.org/10.1021/acs.jmedchem.3c00337

Balbach, Melanie ; Rossetti, Thomas ; Ferreira, Jacob ; Ghanem, Lubna ; Ritagliati, Carla ; Myers, Robert W. ; Huggins, David J. ; Steegborn, Clemens ; Miranda, Ileana C. ; Meinke, Peter T. ; Buck, Jochen ; Levin, Lonny R.:
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
In: Nature Communications. Bd. 14 (2023) Heft 1 . - 637.
DOI: https://doi.org/10.1038/s41467-023-36119-6

Sun, Shan ; Fushimi, Makoto ; Rossetti, Thomas ; Kaur, Navpreet ; Ferreira, Jacob ; Miller, Michael ; Quast, Jonathan ; van den Heuvel, Joop ; Steegborn, Clemens ; Levin, Lonny R. ; Buck, Jochen ; Myers, Robert W. ; Kargman, Stacia ; Liverton, Nigel ; Meinke, Peter T. ; Huggins, David J.:
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
In: Journal of Chemical Information and Modeling. Bd. 63 (2023) Heft 9 . - S. 2828-2841.
DOI: https://doi.org/10.1021/acs.jcim.2c01577

Rossetti, Thomas ; Ferreira, Jacob ; Ghanem, Lubna ; Buck, Hannes ; Steegborn, Clemens ; Myers, Robert W. ; Meinke, Peter T. ; Levin, Lonny R. ; Buck, Jochen:
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
In: Frontiers in Physiology. Bd. 13 (2022) . - 1013845.
DOI: https://doi.org/10.3389/fphys.2022.1013845

Towell, Holly:
Biochemical and structural characterisation of mammalian deiodinases as key regulators of thyroid hormone metabolism.
Bayreuth , 2022 . - X, 95 S.
( Dissertation, 2022 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00006054

Miller, Michael ; Rossetti, Thomas ; Ferreira, Jacob ; Ghanem, Lubna ; Balbach, Melanie ; Kaur, Navpreet ; Levin, Lonny R. ; Buck, Jochen ; Kehr, Maria ; Coquille, Sandrine ; van den Heuvel, Joop ; Steegborn, Clemens ; Fushimi, Makoto ; Finkin-Groner, Efrat ; Myers, Robert W. ; Kargman, Stacia ; Liverton, Nigel J. ; Huggins, David J. ; Meinke, Peter T.:
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
In: Journal of Medicinal Chemistry. Bd. 65 (2022) Heft 22 . - S. 15208-15226.
DOI: https://doi.org/10.1021/acs.jmedchem.2c01133

Rodriguez-Ruiz, Alfonso ; Braun, Doreen ; Pflug, Simon ; Brol, Alexander ; Sylvester, Marc ; Steegborn, Clemens ; Schweizer, Ulrich:
Insights into the Mechanism of Human Deiodinase 1.
In: International Journal of Molecular Sciences. Bd. 23 (2022) Heft 10 . - 5361.
DOI: https://doi.org/10.3390/ijms23105361

Suenkel, Benjamin ; Valente, Sergio ; Zwergel, Clemens ; Weiss, Sandra ; Di Bello, Elisabetta ; Fioravanti, Rossella ; Aventaggiato, Michele ; Amorim, João A. ; Garg, Neha ; Kumar, Surinder ; Lombard, David B. ; Hu, Tuo ; Singh, Pankaj K. ; Tafani, Marco ; Palmeira, Carlos M. ; Sinclair, David ; Mai, Antonello ; Steegborn, Clemens:
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5.
In: Journal of Medicinal Chemistry. Bd. 65 (2022) Heft 20 . - S. 14015-14031.
DOI: https://doi.org/10.1021/acs.jmedchem.2c01215

Weiss, Sandra ; Adolph, Ramona S. ; Schweimer, Kristian ; DiFonzo, Andrea ; Meleshin, Marat ; Schutkowski, Mike ; Steegborn, Clemens:
Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein.
In: International Journal of Molecular Sciences. Bd. 23 (2022) Heft 21 . - 12764.
DOI: https://doi.org/10.3390/ijms232112764

You, Weijie ; Steegborn, Clemens:
Binding site for activator MDL-801 on SIRT6.
In: Nature Chemical Biology. Bd. 17 (1 März 2021) . - S. 519-521.
DOI: https://doi.org/10.1038/s41589-021-00749-y

Ip, James E. ; Xu, Linna ; Dai, Jie ; Steegborn, Clemens ; Jaffré, Fabrice ; Evans, Todd ; Cheung, Jim W. ; Basson, Craig T. ; Panaghie, Gianina ; Krogh-Madsen, Trine ; Abbott, Geoffrey W. ; Lerman, Bruce B.:
Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia.
In: Circulation: Arrhythmia and Electrophysiology. Bd. 14 (2021) Heft 10 . - e010082.
DOI: https://doi.org/10.1161/CIRCEP.121.010082

Fushimi, Makoto ; Buck, Hannes ; Balbach, Melanie ; Gorovyy, Anna ; Ferreira, Jacob ; Rossetti, Thomas ; Kaur, Navpreet ; Levin, Lonny R. ; Buck, Jochen ; Quast, Jonathan ; van den Heuvel, Joop ; Steegborn, Clemens ; Finkin-Groner, Efrat ; Kargman, Stacia ; Michino, Mayako ; Foley, Michael A. ; Miller, Michael ; Liverton, Nigel J. ; Huggins, David J. ; Meinke, Peter T.:
Discovery of TDI-10229 : A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
In: ACS Medicinal Chemistry Letters. Bd. 12 (2021) Heft 8 . - S. 1283-1287.
DOI: https://doi.org/10.1021/acsmedchemlett.1c00273

Hu, Tuo ; Shukla, Surendra K. ; Vernucci, Enza ; He, Chunbo ; Wang, Dezhen ; King, Ryan J. ; Jha, Kanupriya ; Siddhanta, Kasturi ; Mullen, Nicholas J. ; Attri, Kuldeep S. ; Murthy, Divya ; Chaika, Nina V. ; Thakur, Ravi ; Mulder, Scott E. ; Pacheco, Camila G. ; Fu, Xiao ; High, Robin R. ; Yu, Fang ; Lazenby, Audrey ; Steegborn, Clemens ; Lan, Ping ; Mehla, Kamiya ; Rotili, Dante ; Chaudhary, Sarika ; Valente, Sergio ; Tafani, Marco ; Mai, Antonello ; Auwerx, Johan ; Verdin, Eric ; Tuveson, David ; Singh, Pankaj K.:
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
In: Gastroenterology. Bd. 161 (2021) Heft 5 . - S. 1584-1600.
DOI: https://doi.org/10.1053/j.gastro.2021.06.045

Unverzagt, Carlo ; Reif, Andreas ; Lam, Kevin ; Weidler, Sascha ; Lott, Marie ; Boos, Irene ; Lokau, Juliane ; Bretscher, Christian ; Mönnich, Manuel ; Perkams, Lukas ; Schmälzlein, Marina ; Graf, Christopher G. F. ; Fischer, Jan-Patrick ; Lechner, Carolin ; Hallstein, Kerstin ; Becker, Stefan ; Weyand, Michael ; Steegborn, Clemens ; Schultheiss, Gerhard ; Rose-John, Stefan ; Garbers, Christoph:
Natural Glycoforms of Human Interleukin 6 show atypical plasma clearance.
In: Angewandte Chemie International Edition. Bd. 60 (2021) Heft 24 . - S. 13380-13387.
DOI: https://doi.org/10.1002/anie.202101496

Steegborn, Clemens ; Schweizer, Ulrich:
Structure and Mechanism of Iodothyronine Deiodinases : What We Know, What We Don't Know, and What Would Be Nice to Know.
In: Experimental and clinical endocrinology & diabetes. Bd. 128 (7 November 2020) Heft 6/7 . - S. 375-378.
DOI: https://doi.org/10.1055/a-1022-9916

Kleinboelting, Silke ; Miehling, Jonas ; Steegborn, Clemens:
Crystal structure and enzymatic characterization of the putative adenylyl cyclase HpAC1 from Hippeastrum reveal dominant triphosphatase activity.
In: Journal of Structural Biology. Bd. 212 (2020) Heft 3 . - 107649.
DOI: https://doi.org/10.1016/j.jsb.2020.107649

Linder, Jürgen ; Hupfeld, Enrico ; Weyand, Michael ; Steegborn, Clemens ; Moniot, Sébastien:
Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa.
In: Journal of Structural Biology. Bd. 211 (2020) Heft 2 . - 107534.
DOI: https://doi.org/10.1016/j.jsb.2020.107534

Tomassi, Stefano ; Pfahler, Julian ; Mautone, Nicola ; Rovere, Anarita ; Esposito, Chiara ; Passeri, Daniela ; Pellicciari, Roberto ; Novellino, Ettore ; Pannek, Martin ; Steegborn, Clemens ; Paiardini, Alessandro ; Mai, Antonello ; Rotili, Dante:
From PARP1 to TNKS2 Inhibition : A Structure-Based Approach.
In: ACS Medicinal Chemistry Letters. Bd. 11 (2020) Heft 5 . - S. 862-868.
DOI: https://doi.org/10.1021/acsmedchemlett.9b00654

Balbach, Melanie ; Fushimi, Makoto ; Huggins, David J. ; Steegborn, Clemens ; Meinke, Peter T. ; Levin, Lonny R. ; Buck, Jochen:
Optimization of lead compounds into on-demand, nonhormonal contraceptives : leveraging a public-private drug discovery institute collaboration.
In: Biology of Reproduction. Bd. 103 (2020) Heft 2 . - S. 176-182.
DOI: https://doi.org/10.1093/biolre/ioaa052

Tomaselli, Daniela ; Steegborn, Clemens ; Mai, Antonello ; Rotili, Dante:
Sirt4 : A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer.
In: Frontiers in Oncology. Bd. 10 (2020) . - 474.
DOI: https://doi.org/10.3389/fonc.2020.00474

Teodoro, João S. ; Amorim, João Alves ; Machado, Ivo F. ; Castela, Ana C. ; Steegborn, Clemens ; Sinclair, David A. ; Rolo, Anabel P. ; Palmeira, Carlos M.:
The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function.
In: International Journal of Molecular Sciences. Bd. 21 (2020) Heft 14 . - 4896.
DOI: https://doi.org/10.3390/ijms21144896

You, Weijie ; Steegborn, Clemens:
Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin.
In: ACS Medicinal Chemistry Letters. Bd. 11 (2020) Heft 11 . - S. 2285-2289.
DOI: https://doi.org/10.1021/acsmedchemlett.0c00407

You, Weijie:
Activation and inhibition of Sirt6 by small molecules.
Bayreuth , 2019 . - 120 S.
( Dissertation, 2019 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00004450

Weber, Anna M. ; Kaiser, Jennifer ; Ziegler, Thea ; Pilsl, Sebastian ; Renzl, Christian ; Sixt, Lisa ; Pietruschka, Georg ; Moniot, Sébastien ; Kakoti, Ankana ; Juraschitz, Marc ; Schrottke, Stefanie ; Lledo Bryant, Laura ; Steegborn, Clemens ; Bittl, Robert ; Mayer, Günter ; Möglich, Andreas:
A blue light receptor that mediates RNA binding and translational regulation.
In: Nature Chemical Biology. Bd. 15 (2019) . - S. 1085-1092.
DOI: https://doi.org/10.1038/s41589-019-0346-y

Palmeira, Carlos Marques ; Teodoro, João S. ; Amorim, João Alves ; Steegborn, Clemens ; Sinclair, David A. ; Rolo, Anabela Pinto:
Mitohormesis and metabolic health : the interplay between ROS, cAMP and sirtuins.
In: Free Radical Biology and Medicine. Bd. 141 (2019) . - S. 483-491.
DOI: https://doi.org/10.1016/j.freeradbiomed.2019.07.017

You, Weijie ; Zheng, Wei ; Weiß, Sandra ; Chua, Katrin F. ; Steegborn, Clemens:
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
In: Scientific Reports. Bd. 9 (2019) . - 19176.
DOI: https://doi.org/10.15495/EPub_UBT_00004703

Wiggins, Shakarr V. ; Steegborn, Clemens ; Levin, Lonny R. ; Buck, Jochen:
Pharmacological modulation of the CO₂/HCO₃⁻/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.
In: Pharmacology & Therapeutics. Bd. 190 (Oktober 2018) . - S. 173-186.
DOI: https://doi.org/10.1016/j.pharmthera.2018.05.008

Dai, Han ; Sinclair, David A. ; Ellis, James L. ; Steegborn, Clemens:
Sirtuin activators and inhibitors : Promises, achievements, and challenges.
In: Pharmacology & Therapeutics. Bd. 188 (August 2018) . - S. 140-154.
DOI: https://doi.org/10.1016/j.pharmthera.2018.03.004

Pinto, Andrea ; El Ali, Zeina ; Moniot, Sébastien ; Tamborini, Lucia ; Steegborn, Clemens ; Foresti, Roberta ; de Micheli, Carlo:
Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression.
In: ChemistryOpen. Bd. 7 (2018) Heft 11 . - S. 858-864.
DOI: https://doi.org/10.1002/open.201800185

Lachettini, Sara ; Trisciuoglio, Daniela ; Rotili, Dante ; Lucidi, Alessia ; Salvati, Erica ; Zizza, Pasquale ; di Leo, Luca ; del Bufalo, Donatella ; Ciriolo, Maria Rosa ; Leonetti, Carlo ; Steegborn, Clemens ; Mai, Antonello ; Rizzo, Angela ; Biroccio, Annamaria:
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
In: Cell Death & Disease. Bd. 9 (2018) . - 996.
DOI: https://doi.org/10.1038/s41419-018-1065-0

Kalbas, Diana ; Liebscher, Sandra ; Nowak, Theresa ; Meleshin, Marat ; Pannek, Martin ; Popp, Corinna ; Alhalabi, Zayan ; Bordusa, Frank ; Sippl, Wolfgang ; Steegborn, Clemens ; Schutkowski, Mike:
Potent and Selective Inhibitors of Human Sirtuin 5.
In: Journal of Medicinal Chemistry. Bd. 61 (2018) Heft 6 . - S. 2460-2471.
DOI: https://doi.org/10.1021/acs.jmedchem.7b01648

You, Weijie ; Steegborn, Clemens:
Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A : Implications for Protein Deacylase Drug Development.
In: Journal of Medicinal Chemistry. Bd. 61 (2018) Heft 23 . - S. 10922-10928.
DOI: https://doi.org/10.1021/acs.jmedchem.8b01455

Pannek, Martin ; Simic, Zeljko ; Fuszard, Matthew ; Meleshin, Marat ; Rotili, Dante ; Mai, Antonello ; Schutkowski, Mike ; Steegborn, Clemens:
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.
In: Nature Communications. Bd. 8 (15 November 2017) . - Article number 1513 (13 Seiten).
DOI: https://doi.org/10.1038/s41467-017-01701-2

Li, Jun ; Bonkowski, Michael S. ; Moniot, Sébastien ; Zhang, Dapeng ; Hubbard, Basil P. ; Ling, Alvin J. Y. ; Rajman, Luis A. ; Qin, Bo ; Lou, Zhenkun ; Gorbunova, Vera ; Aravind, L. ; Steegborn, Clemens ; Sinclair, David A.:
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.
In: Science. Bd. 355 (2017) Heft 6331 . - S. 1312-1317.
DOI: https://doi.org/10.1126/science.aad8242

de Oliveira, Rita Machado ; Vicente Miranda, Hugo ; Francelle, Laetitia ; Pinho, Raquel ; Szegö, Éva M. ; Martinho, Renato ; Munari, Francesca ; Lázaro, Diana F. ; Moniot, Sébastien ; Guerreiro, Patrícia ; Fonseca-Ornelas, Luis ; Marijanovic, Zrinka ; Antas, Pedro ; Gerhardt, Ellen ; Enguita, Francisco Javier ; Fauvet, Bruno ; Penque, Deborah ; Pais, Teresa Faria ; Tong, Qiang ; Becker, Stefan ; Kügler, Sebastian ; Lashuel, Hilal Ahmed ; Steegborn, Clemens ; Zweckstetter, Markus ; Outeiro, Tiago F.:
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
In: PLoS Biology. Bd. 15 (2017) Heft 4 . - No. e1002601.
DOI: https://doi.org/10.1371/journal.pbio.1002601

Moniot, Sébastien ; Forgione, Mariantonietta ; Lucidi, Alessia ; Hailu, Gebremedhin S. ; Nebbioso, Angela ; Carafa, Vincenzo ; Baratta, Francesca ; Altucci, Lucia ; Giacché, Nicola ; Passeri, Daniela ; Pellicciari, Roberto ; Mai, Antonello ; Steegborn, Clemens ; Rotili, Dante:
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2 : Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
In: Journal of Medicinal Chemistry. Bd. 60 (2017) Heft 6 . - S. 2344-2360.
DOI: https://doi.org/10.1021/acs.jmedchem.6b01609

Quinti, Luisa ; Dayalan Naidu, Sharadha ; Träger, Ulrike ; Chen, Xiqun ; Kegel-Gleason, Kimberly ; Llères, David ; Connolly, Colúm ; Chopra, Vanita ; Low, Cho ; Moniot, Sébastien ; Sapp, Ellen ; Tousley, Adelaide R. ; Vodicka, Petr ; van Kanegan, Michael J. ; Kaltenbach, Linda S. ; Crawford, Lisa A. ; Fuszard, Matthew ; Higgins, Maureen ; Miller, James R. C. ; Farmer, Ruth E. ; Potluri, Vijay ; Samajdar, Susanta ; Meisel, Lisa ; Zhang, Ningzhe ; Snyder, Andrew ; Stein, Ross ; Hersch, Steven M. ; Ellerby, Lisa M. ; Weerapana, Eranthie ; Schwarzschild, Michael A. ; Steegborn, Clemens ; Leavitt, Blair R. ; Degterev, Alexei ; Tabrizi, Sarah J. ; Lo, Donald C. ; DiFiglia, Marian ; Thompson, Leslie M. ; Dinkova-Kostova, Albena T. ; Kazantsev, Aleksey G.:
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 114 (2017) Heft 23 . - S. E4676-E4685.
DOI: https://doi.org/10.1073/pnas.1614943114

de Oliveira, Rita Machado ; Vicente Miranda, Hugo ; Francelle, Laetitia ; Pinho, Raquel ; Szegö, Éva M. ; Martinho, Renato ; Munari, Francesca ; Lázaro, Diana F. ; Moniot, Sébastien ; Guerreiro, Patrícia ; Fonseca, Luis ; Marijanovic, Zrinka ; Antas, Pedro ; Gerhardt, Ellen ; Enguita, Francisco Javier ; Fauvet, Bruno ; Penque, Deborah ; Pais, Teresa Faria ; Tong, Qiang ; Becker, Stefan ; Kügler, Sebastian ; Lashuel, Hilal Ahmed ; Steegborn, Clemens ; Zweckstetter, Markus ; Outeiro, Tiago F.:
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
In: PLoS Biology. Bd. 15 (2017) Heft 3 . - No. e2000374.
DOI: https://doi.org/10.1371/journal.pbio.2000374

Rajabi, Nima ; Auth, Marina ; Troelsen, Kathrin R. ; Pannek, Martin ; Bhatt, Dhaval ; Fontenas, Martin ; Hirshey, Matthew D. ; Steegborn, Clemens ; Madsen, Andreas S. ; Olsen, Christian Adam:
Mechanism-based Inhibitors of the Human Sirtuin 5 Deacylase : Structure-Activity Relationship, Biostructural, and Kinetic Insight.
In: Angewandte Chemie International Edition. Bd. 56 (2017) Heft 47 . - S. 14836-14841.
DOI: https://doi.org/10.1002/anie.201709050

Schweizer, Ulrich ; Towell, Holly ; Vit, Allegra ; Rodriguez-Ruiz, Alfonso ; Steegborn, Clemens:
Structural aspects of thyroid hormone binding to proteins and competitive interactions with natural and synthetic compounds.
In: Molecular and Cellular Endocrinology. Bd. 458 (2017) . - S. 57-67.
DOI: https://doi.org/10.1016/j.mce.2017.01.026

You, Weijie ; Rotili, Dante ; Li, Tie-Mei ; Kambach, Christian ; Meleshin, Marat ; Schutkowski, Mike ; Chua, Katrin F. ; Mai, Antonello ; Steegborn, Clemens:
Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.
In: Angewandte Chemie International Edition. Bd. 56 (2017) Heft 4 . - S. 1007-1011.
DOI: https://doi.org/10.1002/anie.201610082

Graf, Christopher G. F. ; Schulz, Christian ; Schmälzlein, Marina ; Heinlein, Christian ; Mönnich, Manuel ; Perkams, Lukas ; Püttner, Markus ; Boos, Irene ; Hessefort, Markus ; Lombana Sanchez, Jose Nelson ; Weyand, Michael ; Steegborn, Clemens ; Breiden, Bernadette ; Ross, Kerstin ; Schwarzmann, Günter ; Sandhoff, Konrad ; Unverzagt, Carlo:
Synthetic Glycoforms Reveal Carbohydrate-Dependent Bioactivity of Human Saposin D.
In: Angewandte Chemie International Edition. Bd. 56 (2017) Heft 19 . - S. 5252-5257.
DOI: https://doi.org/10.1002/anie.201701362

Sundriyal, Sandeep ; Moniot, Sébastien ; Mahmud, Zimam ; Yao, Shang ; di Fruscia, Paolo ; Reynolds, Christopher R. ; Dexter, David T. ; Sternberg, Michael J. E. ; Lam, Eric W.-F. ; Steegborn, Clemens ; Fuchter, Matthew J.:
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.
In: Journal of Medicinal Chemistry. Bd. 60 (2017) Heft 5 . - S. 1928-1945.
DOI: https://doi.org/10.1021/acs.jmedchem.6b01690

Ramos-Espiritu, Lavoisier ; Kleinbölting, Silke ; Navarrete, Felipe A. ; Alvau, Antonio ; Visconti, Pablo E. ; Valsecchi, Federica ; Starkov, Anatoly ; Manfredi, Giovanni ; Buck, Hannes ; Adura, Carolina ; Zippin, Jonathan H. ; van den Heuvel, Joop ; Glickman, J. Fraser ; Steegborn, Clemens ; Levin, Lonny R. ; Buck, Jochen:
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.
In: Nature Chemical Biology. Bd. 12 (Oktober 2016) Heft 10 . - S. 838-844.
DOI: https://doi.org/10.1038/nchembio.2151

Valente, Sergio ; Mellini, Paolo ; Spallotta, Francesco ; Carafa, Vincenzo ; Nebbioso, Angela ; Polletta, Lucia ; Carnevale, Ilaria ; Saladini, Serena ; Trisciuoglio, Daniela ; Gabellini, Chiara ; Tardugno, Maria ; Zwergel, Clemens ; Cencioni, Chiara ; Atlante, Sandra ; Moniot, Sébastien ; Steegborn, Clemens ; Budriesi, Roberta ; Tafani, Marco ; del Bufalo, Donatella ; Altucci, Lucia ; Gaetano, Carlo ; Mai, Antonello:
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.
In: Journal of Medicinal Chemistry. Bd. 59 (2016) Heft 4 . - S. 1471-1491.
DOI: https://doi.org/10.1021/acs.jmedchem.5b01117

Kleinbölting, Silke ; Ramos-Espiritu, Lavoisier ; Buck, Hannes ; Colis, Laureen ; van den Heuvel, Joop ; Glickman, J. Fraser ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric activator site.
In: The Journal of Biological Chemistry. Bd. 291 (2016) Heft 18 . - S. 9776-9784.
DOI: https://doi.org/10.1074/jbc.M115.708255

Schuster, Sabine ; Roessler, Claudia ; Meleshin, Marat ; Zimmermann, Philipp ; Simic, Zeljko ; Kambach, Christian ; Schiene-Fischer, Cordelia ; Steegborn, Clemens ; Hottiger, Michael O. ; Schutkowski, Mike:
A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions.
In: Scientific Reports. Bd. 6 (2016) . - 22643.
DOI: https://doi.org/10.1038/srep22643

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Kalvakolanu, Dhan V ; Kamada, Yoshiaki ; Kambas, Konstantinos ; Kaminskyy, Vitaliy O ; Kampinga, Harm H ; Kandouz, Mustapha ; Kang, Chanhee ; Kang, Rui ; Kang, Tae-Cheon ; Kanki, Tomotake ; Kanneganti, Thirumala-Devi ; Kanno, Haruo ; Kanthasamy, Anumantha G ; Kantorow, Marc ; Kaparakis-Liaskos, Maria ; Kapuy, Orsolya ; Karantza, Vassiliki ; Karim, Md Razaul ; Karmakar, Parimal ; Kaser, Arthur ; Kaushik, Susmita ; Kawula, Thomas ; Kaynar, A Murat ; Ke, Po-Yuan ; Ke, Zun-Ji ; Kehrl, John H ; Keller, Kate E ; Kemper, Jongsook Kim ; Kenworthy, Anne K ; Kepp, Oliver ; Kern, Andreas ; Kesari, Santosh ; Kessel, David ; Ketteler, Robin ; Kettelhut, Isis do Carmo ; Khambu, Bilon ; Khan, Muzamil Majid ; Khandelwal, Vinoth Km ; Khare, Sangeeta ; Kiang, Juliann G ; Kiger, Amy A ; Kihara, Akio ; Kim, Arianna L ; Kim, Cheol Hyeon ; Kim, Deok Ryong ; Kim, Do-Hyung ; Kim, Eung Kweon ; Kim, Hye Young ; Kim, Hyung-Ryong ; Kim, Jae-Sung ; Kim, Jeong Hun ; Kim, Jin Cheon ; Kim, Jin Hyoung ; Kim, Kwang Woon ; Kim, Michael D ; Kim, Moon-Moo ; Kim, Peter K ; Kim, Seong Who ; Kim, Soo-Youl ; Kim, Yong-Sun ; Kim, Yonghyun ; Kimchi, Adi ; Kimmelman, Alec C ; Kimura, Tomonori ; King, Jason S ; Kirkegaard, Karla ; Kirkin, Vladimir ; Kirshenbaum, Lorrie A ; Kishi, Shuji ; Kitajima, Yasuo ; Kitamoto, Katsuhiko ; Kitaoka, Yasushi ; Kitazato, Kaio ; Kley, Rudolf A ; Klimecki, Walter T ; Klinkenberg, Michael ; Klucken, Jochen ; Knævelsrud, Helene ; Knecht, Erwin ; Knuppertz, Laura ; Ko, Jiunn-Liang ; Kobayashi, Satoru ; Koch, Jan C ; Koechlin-Ramonatxo, Christelle ; Koenig, Ulrich ; Koh, Young Ho ; Köhler, Katja ; Kohlwein, Sepp D ; Koike, Masato ; Komatsu, Masaaki ; Kominami, Eiki ; Kong, Dexin ; Kong, Hee Jeong ; Konstantakou, Eumorphia G ; Kopp, Benjamin T ; Korcsmaros, Tamas ; Korhonen, Laura ; Korolchuk, Viktor I ; Koshkina, Nadya V ; Kou, Yanjun ; Koukourakis, Michael I ; Koumenis, Constantinos ; Kovács, Attila L ; Kovács, Tibor ; Kovacs, Werner J ; Koya, Daisuke ; Kraft, Claudine ; Krainc, Dimitri ; Kramer, Helmut ; Kravic-Stevovic, Tamara ; Krek, Wilhelm ; Kretz-Remy, Carole ; Krick, Roswitha ; Krishnamurthy, Malathi ; Kriston-Vizi, Janos ; Kroemer, Guido ; Kruer, Michael C ; Kruger, Rejko ; Ktistakis, Nicholas T ; Kuchitsu, Kazuyuki ; Kuhn, Christian ; Kumar, Addanki Pratap ; Kumar, Anuj ; Kumar, Ashok ; Kumar, Deepak ; Kumar, Dhiraj ; Kumar, Rakesh ; Kumar, Sharad ; Kundu, Mondira ; Kung, Hsing-Jien ; Kuno, Atsushi ; Kuo, Sheng-Han ; Kuret, Jeff ; Kurz, Tino ; Kwok, Terry ; Kwon, Taeg Kyu ; Kwon, Yong Tae ; Kyrmizi, Irene ; La Spada, Albert R ; Lafont, Frank ; Lahm, Tim ; Lakkaraju, Aparna ; Lam, Truong ; Lamark, Trond ; Lancel, Steve ; Landowski, Terry H ; Lane, Darius Jr ; Lane, Jon D ; Lanzi, Cinzia ; Lapaquette, Pierre ; Lapierre, Louis R ; Laporte, Jocelyn ; Laukkarinen, Johanna ; Laurie, Gordon W ; Lavandero, Sergio ; Lavie, Lena ; LaVoie, Matthew J ; Law, Betty Yuen Kwan ; Law, Helen Ka-Wai ; Law, Kelsey B ; Layfield, Robert ; Lazo, Pedro A ; Le Cam, Laurent ; Le Roch, Karine G ; Le Stunff, Hervé ; Leardkamolkarn, Vijittra ; Lecuit, Marc ; Lee, Byung-Hoon ; Lee, Che-Hsin ; Lee, Erinna F ; Lee, Gyun Min ; Lee, He-Jin ; Lee, Hsinyu ; Lee, Jae Keun ; Lee, Jongdae ; Lee, Ju-Hyun ; Lee, Jun Hee ; Lee, Michael ; Lee, Myung-Shik ; Lee, Patty J ; Lee, Sam W ; Lee, Seung-Jae ; Lee, Shiow-Ju ; Lee, Stella Y ; Lee, Sug Hyung ; Lee, Sung Sik ; Lee, Sung-Joon ; Lee, Sunhee ; Lee, Ying-Ray ; Lee, Yong J ; Lee, Young H ; Leeuwenburgh, Christiaan ; Lefort, Sylvain ; Legouis, Renaud ; Lei, Jinzhi ; Lei, Qun-Ying ; Leib, David A ; Leibowitz, Gil ; Lekli, Istvan ; Lemaire, Stéphane D ; Lemasters, John J ; Lemberg, Marius K ; Lemoine, Antoinette ; Leng, Shuilong ; Lenz, Guido ; Lenzi, Paola ; Lerman, Lilach O ; Lettieri Barbato, Daniele ; Leu, Julia I-Ju ; Leung, Hing Y ; Levine, Beth ; Lewis, Patrick A ; Lezoualc'h, Frank ; Li, Chi ; Li, Faqiang ; Li, Feng-Jun ; Li, Jun ; Li, Ke ; Li, Lian ; Li, Min ; Li, Min ; Li, Qiang ; Li, Rui ; Li, Sheng ; Li, Wei ; Li, Wei ; Li, Xiaotao ; Li, Yumin ; Lian, Jiqin ; Liang, Chengyu ; Liang, Qiangrong ; Liao, Yulin ; Liberal, Joana ; Liberski, Pawel P ; Lie, Pearl ; Lieberman, Andrew P ; Lim, Hyunjung Jade ; Lim, Kah-Leong ; Lim, Kyu ; Lima, Raquel T ; Lin, Chang-Shen ; Lin, Chiou-Feng ; Lin, Fang ; Lin, Fangming ; Lin, Fu-Cheng ; Lin, Kui ; Lin, Kwang-Huei ; Lin, Pei-Hui ; Lin, Tianwei ; Lin, Wan-Wan ; Lin, Yee-Shin ; Lin, Yong ; Linden, Rafael ; Lindholm, Dan ; Lindqvist, Lisa M ; Lingor, Paul ; Linkermann, Andreas ; Liotta, Lance A ; Lipinski, Marta M ; Lira, Vitor A ; Lisanti, Michael P ; Liton, Paloma B ; Liu, Bo ; Liu, Chong ; Liu, Chun-Feng ; Liu, Fei ; Liu, Hung-Jen ; Liu, Jianxun ; Liu, Jing-Jing ; Liu, Jing-Lan ; Liu, Ke ; Liu, Leyuan ; Liu, Liang ; Liu, Quentin ; Liu, Rong-Yu ; Liu, Shiming ; Liu, Shuwen ; Liu, Wei ; Liu, Xian-De ; Liu, Xiangguo ; Liu, Xiao-Hong ; Liu, Xinfeng ; Liu, Xu ; Liu, Xueqin ; Liu, Yang ; Liu, Yule ; Liu, Zexian ; Liu, Zhe ; Liuzzi, Juan P ; Lizard, Gérard ; Ljujic, Mila ; Lodhi, Irfan J ; Logue, Susan E ; Lokeshwar, Bal L ; Long, Yun Chau ; Lonial, Sagar ; Loos, Benjamin ; López-Otín, Carlos ; López-Vicario, Cristina ; Lorente, Mar ; Lorenzi, Philip L ; Lõrincz, Péter ; Los, Marek ; Lotze, Michael T ; Lovat, Penny E ; Lu, Binfeng ; Lu, Bo ; Lu, Jiahong ; Lu, Qing ; Lu, She-Min ; Lu, Shuyan ; Lu, Yingying ; Luciano, Frédéric ; Luckhart, Shirley ; Lucocq, John Milton ; Ludovico, Paula ; Lugea, Aurelia ; Lukacs, Nicholas W ; Lum, Julian J ; Lund, Anders H ; Luo, Honglin ; Luo, Jia ; Luo, Shouqing ; Luparello, Claudio ; Lyons, Timothy ; Ma, Jianjie ; Ma, Yi ; Ma, Yong ; Ma, Zhenyi ; Machado, Juliano ; Machado-Santelli, Glaucia M ; Macian, Fernando ; MacIntosh, Gustavo C ; MacKeigan, Jeffrey P ; Macleod, Kay F ; MacMicking, John D ; MacMillan-Crow, Lee Ann ; Madeo, Frank ; Madesh, Muniswamy ; Madrigal-Matute, Julio ; Maeda, Akiko ; Maeda, Tatsuya ; Maegawa, Gustavo ; Maellaro, Emilia ; Maes, Hannelore ; Magariños, Marta ; Maiese, Kenneth ; Maiti, Tapas K ; Maiuri, Luigi ; Maiuri, Maria Chiara ; Maki, Carl G ; Malli, Roland ; Malorni, Walter ; Maloyan, Alina ; Mami-Chouaib, Fathia ; Man, Na ; Mancias, Joseph D ; Mandelkow, Eva-Maria ; Mandell, Michael A ; Manfredi, Angelo A ; Manié, Serge N ; Manzoni, Claudia ; Mao, Kai ; Mao, Zixu ; Mao, Zong-Wan ; Marambaud, Philippe ; Marconi, Anna Maria ; Marelja, Zvonimir ; Marfe, Gabriella ; Margeta, Marta ; Margittai, Eva ; Mari, Muriel ; Mariani, Francesca V ; Marin, Concepcio ; Marinelli, Sara ; Mariño, Guillermo ; Markovic, Ivanka ; Marquez, Rebecca ; Martelli, Alberto M ; Martens, Sascha ; Martin, Katie R ; Martin, Seamus J ; Martin, Shaun ; Martin-Acebes, Miguel A ; Martín-Sanz, Paloma ; Martinand-Mari, Camille ; Martinet, Wim ; Martinez, Jennifer ; Martinez-Lopez, Nuria ; Martinez-Outschoorn, Ubaldo ; Martínez-Velázquez, Moisés ; Martinez-Vicente, Marta ; Martins, Waleska Kerllen ; Mashima, Hirosato ; Mastrianni, James A ; Matarese, Giuseppe ; Matarrese, Paola ; Mateo, Roberto ; Matoba, Satoaki ; Matsumoto, Naomichi ; Matsushita, Takehiko ; Matsuura, Akira ; Matsuzawa, Takeshi ; Mattson, Mark P ; Matus, Soledad ; Maugeri, Norma ; Mauvezin, Caroline ; Mayer, Andreas ; Maysinger, Dusica ; Mazzolini, Guillermo D ; McBrayer, Mary Kate ; McCall, Kimberly ; McCormick, Craig ; McInerney, Gerald M ; McIver, Skye C ; McKenna, Sharon ; McMahon, John J ; McNeish, Iain A ; Mechta-Grigoriou, Fatima ; Medema, Jan Paul ; Medina, Diego L ; Megyeri, Klara ; Mehrpour, Maryam ; Mehta, Jawahar L ; Mei, Yide ; Meier, Ute-Christiane ; Meijer, Alfred J ; Meléndez, Alicia ; Melino, Gerry ; Melino, Sonia ; de Melo, Edesio Jose Tenorio ; Mena, Maria A ; Meneghini, Marc D ; Menendez, Javier A ; Menezes, Regina ; Meng, Liesu ; Meng, Ling-Hua ; Meng, Songshu ; Menghini, Rossella ; Menko, A Sue ; Menna-Barreto, Rubem Fs ; Menon, Manoj B ; Meraz-Ríos, Marco A ; Merla, Giuseppe ; Merlini, Luciano ; Merlot, Angelica M ; Meryk, Andreas ; Meschini, Stefania ; Meyer, Joel N ; Mi, Man-Tian ; Miao, Chao-Yu ; Micale, Lucia ; Michaeli, Simon ; Michiels, Carine ; Migliaccio, Anna Rita ; Mihailidou, Anastasia Susie ; Mijaljica, Dalibor ; Mikoshiba, Katsuhiko ; Milan, Enrico ; Miller-Fleming, Leonor ; Mills, Gordon B ; Mills, Ian G ; Minakaki, Georgia ; Minassian, Berge A ; Ming, Xiu-Fen ; Minibayeva, Farida ; Minina, Elena A ; Mintern, Justine D ; Minucci, Saverio ; Miranda-Vizuete, Antonio ; Mitchell, Claire H ; Miyamoto, Shigeki ; Miyazawa, Keisuke ; Mizushima, Noboru ; Mnich, Katarzyna ; Mograbi, Baharia ; Mohseni, Simin ; Moita, Luis Ferreira ; Molinari, Marco ; Molinari, Maurizio ; Møller, Andreas Buch ; Mollereau, Bertrand ; Mollinedo, Faustino ; Mongillo, Marco ; Monick, Martha M ; Montagnaro, Serena ; Montell, Craig ; Moore, Darren J ; Moore, Michael N ; Mora-Rodriguez, Rodrigo ; Moreira, Paula I ; Morel, Etienne ; Morelli, Maria Beatrice ; Moreno, Sandra ; Morgan, Michael J ; Moris, Arnaud ; Moriyasu, Yuji ; Morrison, Janna L ; Morrison, Lynda A ; Morselli, Eugenia ; Moscat, Jorge ; Moseley, Pope L ; Mostowy, Serge ; Motori, Elisa ; Mottet, Denis ; Mottram, Jeremy C ; Moussa, Charbel E-H ; Mpakou, Vassiliki E ; Mukhtar, Hasan ; Mulcahy Levy, Jean M ; Muller, Sylviane ; Muñoz-Moreno, Raquel ; Muñoz-Pinedo, Cristina ; Münz, Christian ; Murphy, Maureen E ; Murray, James T ; Murthy, Aditya ; Mysorekar, Indira U ; Nabi, Ivan R ; Nabissi, Massimo ; Nader, Gustavo A ; Nagahara, Yukitoshi ; Nagai, Yoshitaka ; Nagata, Kazuhiro ; Nagelkerke, Anika ; Nagy, Péter ; Naidu, Samisubbu R ; Nair, Sreejayan ; Nakano, Hiroyasu ; Nakatogawa, Hitoshi ; Nanjundan, Meera ; Napolitano, Gennaro ; Naqvi, Naweed I ; Nardacci, Roberta ; Narendra, Derek P ; Narita, Masashi ; Nascimbeni, Anna Chiara ; Natarajan, Ramesh ; Navegantes, Luiz C ; Nawrocki, Steffan T ; Nazarko, Taras Y ; Nazarko, Volodymyr Y ; Neill, Thomas ; Neri, Luca M ; Netea, Mihai G ; Netea-Maier, Romana T ; Neves, Bruno M ; Ney, Paul A ; Nezis, Ioannis P ; Nguyen, Hang Tt ; Nguyen, Huu Phuc ; Nicot, Anne-Sophie ; Nilsen, Hilde ; Nilsson, Per ; Nishimura, Mikio ; Nishino, Ichizo ; Niso-Santano, Mireia ; Niu, Hua ; Nixon, Ralph A ; Njar, Vincent Co ; Noda, Takeshi ; Noegel, Angelika A ; Nolte, Elsie Magdalena ; Norberg, Erik ; Norga, Koenraad K ; Noureini, Sakineh Kazemi ; Notomi, Shoji ; Notterpek, Lucia ; Nowikovsky, Karin ; Nukina, Nobuyuki ; Nürnberger, Thorsten ; O'Donnell, Valerie B ; O'Donovan, Tracey ; O'Dwyer, Peter J ; Oehme, Ina ; Oeste, Clara L ; Ogawa, Michinaga ; Ogretmen, Besim ; Ogura, Yuji ; Oh, Young J ; Ohmuraya, Masaki ; Ohshima, Takayuki ; Ojha, Rani ; Okamoto, Koji ; Okazaki, Toshiro ; Oliver, F Javier ; Ollinger, Karin ; Olsson, Stefan ; Orban, Daniel P ; Ordonez, Paulina ; Orhon, Idil ; Orosz, Laszlo ; O'Rourke, Eyleen J ; Orozco, Helena ; Ortega, Angel L ; Ortona, Elena ; Osellame, Laura D ; Oshima, Junko ; Oshima, Shigeru ; Osiewacz, Heinz D ; Otomo, Takanobu ; Otsu, Kinya ; Ou, Jing-Hsiung James ; Outeiro, Tiago F ; Ouyang, Dong-Yun ; Ouyang, Hongjiao ; Overholtzer, Michael ; Ozbun, Michelle A ; Ozdinler, P Hande ; Ozpolat, Bulent ; Pacelli, Consiglia ; Paganetti, Paolo ; Page, Guylène ; Pages, Gilles ; Pagnini, Ugo ; Pajak, Beata ; Pak, Stephen C ; Pakos-Zebrucka, Karolina ; Pakpour, Nazzy ; Palková, Zdena ; Palladino, Francesca ; Pallauf, Kathrin ; Pallet, Nicolas ; Palmieri, Marta ; Paludan, Søren R ; Palumbo, Camilla ; Palumbo, Silvia ; Pampliega, Olatz ; Pan, Hongming ; Pan, Wei ; Panaretakis, Theocharis ; Pandey, Aseem ; Pantazopoulou, Areti ; Papackova, Zuzana ; Papademetrio, Daniela L ; Papassideri, Issidora ; Papini, Alessio ; Parajuli, Nirmala ; Pardo, Julian ; Parekh, Vrajesh V ; Parenti, Giancarlo ; Park, Jong-In ; Park, Junsoo ; Park, Ohkmae K ; Parker, Roy ; Parlato, Rosanna ; Parys, Jan B ; Parzych, Katherine R ; Pasquet, Jean-Max ; Pasquier, Benoit ; Pasumarthi, Kishore Bs ; Patschan, Daniel ; Patterson, Cam ; Pattingre, Sophie ; Pattison, Scott ; Pause, Arnim ; Pavenstädt, Hermann ; Pavone, Flaminia ; Pedrozo, Zully ; Peña, Fernando J ; Peñalva, Miguel A ; Pende, Mario ; Peng, Jianxin ; Penna, Fabio ; Penninger, Josef M ; Pensalfini, Anna ; Pepe, Salvatore ; Pereira, Gustavo Js ; Pereira, Paulo C ; Pérez-de la Cruz, Verónica ; Pérez-Pérez, María Esther ; Pérez-Rodríguez, Diego ; Pérez-Sala, Dolores ; Perier, Celine ; Perl, Andras ; Perlmutter, David H ; Perrotta, Ida ; Pervaiz, Shazib ; Pesonen, Maija ; Pessin, Jeffrey E ; Peters, Godefridus J ; Petersen, Morten ; Petrache, Irina ; Petrof, Basil J ; Petrovski, Goran ; Phang, James M ; Piacentini, Mauro ; Pierdominici, Marina ; Pierre, Philippe ; Pierrefite-Carle, Valérie ; Pietrocola, Federico ; Pimentel-Muiños, Felipe X ; Pinar, Mario ; Pineda, Benjamin ; Pinkas-Kramarski, Ronit ; Pinti, Marcello ; Pinton, Paolo ; Piperdi, Bilal ; Piret, James M ; Platanias, Leonidas C ; Platta, Harald W ; Plowey, Edward D ; Pöggeler, Stefanie ; Poirot, Marc ; Polčic, Peter ; Poletti, Angelo ; Poon, Audrey H ; Popelka, Hana ; Popova, Blagovesta ; Poprawa, Izabela ; Poulose, Shibu M ; Poulton, Joanna ; Powers, Scott K ; Powers, Ted ; Pozuelo-Rubio, Mercedes ; Prak, Krisna ; Prange, Reinhild ; Prescott, Mark ; Priault, Muriel ; Prince, Sharon ; Proia, Richard L ; Proikas-Cezanne, Tassula ; Prokisch, Holger ; Promponas, Vasilis J ; Przyklenk, Karin ; Puertollano, Rosa ; Pugazhenthi, Subbiah ; Puglielli, Luigi ; Pujol, Aurora ; Puyal, Julien ; Pyeon, Dohun ; Qi, Xin ; Qian, Wen-Bin ; Qin, Zheng-Hong ; Qiu, Yu ; Qu, Ziwei ; Quadrilatero, Joe ; Quinn, Frederick ; Raben, Nina ; Rabinowich, Hannah ; Radogna, Flavia ; Ragusa, Michael J ; Rahmani, Mohamed ; Raina, Komal ; Ramanadham, Sasanka ; Ramesh, Rajagopal ; Rami, Abdelhaq ; Randall-Demllo, Sarron ; Randow, Felix ; Rao, Hai ; Rao, V Ashutosh ; Rasmussen, Blake B ; Rasse, Tobias M ; Ratovitski, Edward A ; Rautou, Pierre-Emmanuel ; Ray, Swapan K ; Razani, Babak ; Reed, Bruce H ; Reggiori, Fulvio ; Rehm, Markus ; Reichert, Andreas S ; Rein, Theo ; Reiner, David J ; Reits, Eric ; Ren, Jun ; Ren, Xingcong ; Renna, Maurizio ; Reusch, Jane Eb ; Revuelta, Jose L ; Reyes, Leticia ; Rezaie, Alireza R ; Richards, Robert I ; Richardson, Des R ; Richetta, Clémence ; Riehle, Michael A ; Rihn, Bertrand H ; Rikihisa, Yasuko ; Riley, Brigit E ; Rimbach, Gerald ; Rippo, Maria Rita ; Ritis, Konstantinos ; Rizzi, Federica ; Rizzo, Elizete ; Roach, Peter J ; Robbins, Jeffrey ; Roberge, Michel ; Roca, Gabriela ; Roccheri, Maria Carmela ; Rocha, Sonia ; Rodrigues, Cecilia Mp ; Rodríguez, Clara I ; de Cordoba, Santiago Rodriguez ; Rodriguez-Muela, Natalia ; Roelofs, Jeroen ; Rogov, Vladimir V ; Rohn, Troy T ; Rohrer, Bärbel ; Romanelli, Davide ; Romani, Luigina ; Romano, Patricia Silvia ; Roncero, M Isabel G ; Rosa, Jose Luis ; Rosello, Alicia ; Rosen, Kirill V ; Rosenstiel, Philip ; Rost-Roszkowska, Magdalena ; Roth, Kevin A ; Roué, Gael ; Rouis, Mustapha ; Rouschop, Kasper M ; Ruan, Daniel T ; Ruano, Diego ; Rubinsztein, David C ; Rucker, Edmund B ; Rudich, Assaf ; Rudolf, Emil ; Rudolf, Ruediger ; Ruegg, Markus A ; Ruiz-Roldan, Carmen ; Ruparelia, Avnika Ashok ; Rusmini, Paola ; Russ, David W ; Russo, Gian Luigi ; Russo, Giuseppe ; Russo, Rossella ; Rusten, Tor Erik ; Ryabovol, Victoria ; Ryan, Kevin M ; Ryter, Stefan W ; Sabatini, David M ; Sacher, Michael ; Sachse, Carsten ; Sack, Michael N ; Sadoshima, Junichi ; Saftig, Paul ; Sagi-Eisenberg, Ronit ; Sahni, Sumit ; Saikumar, Pothana ; Saito, Tsunenori ; Saitoh, Tatsuya ; Sakakura, Koichi ; Sakoh-Nakatogawa, Machiko ; Sakuraba, Yasuhito ; Salazar-Roa, María ; Salomoni, Paolo ; Saluja, Ashok K ; Salvaterra, Paul M ; Salvioli, Rosa ; Samali, Afshin ; Sanchez, Anthony Mj ; Sánchez-Alcázar, José A ; Sanchez-Prieto, Ricardo ; Sandri, Marco ; Sanjuan, Miguel A ; Santaguida, Stefano ; Santambrogio, Laura ; Santoni, Giorgio ; Dos Santos, Claudia Nunes ; Saran, Shweta ; Sardiello, Marco ; Sargent, Graeme ; Sarkar, Pallabi ; Sarkar, Sovan ; Sarrias, Maria Rosa ; Sarwal, Minnie M ; Sasakawa, Chihiro ; Sasaki, Motoko ; Sass, Miklos ; Sato, Ken ; Sato, Miyuki ; Satriano, Joseph ; Savaraj, Niramol ; Saveljeva, Svetlana ; Schaefer, Liliana ; Schaible, Ulrich E ; Scharl, Michael ; Schatzl, Hermann M. ; Schekman, Randy ; Scheper, Wiep ; Schiavi, Alfonso ; Schipper, Hyman M ; Schmeisser, Hana ; Schmidt, Jens ; Schmitz, Ingo ; Schneider, Bianca E ; Schneider, E Marion ; Schneider, Jaime L ; Schon, Eric A ; Schönenberger, Miriam J ; Schönthal, Axel H ; Schorderet, Daniel F ; Schröder, Bernd ; Schuck, Sebastian ; Schulze, Ryan J ; Schwarten, Melanie ; Schwarz, Thomas L ; Sciarretta, Sebastiano ; Scotto, Kathleen ; Scovassi, A Ivana ; Screaton, Robert A ; Screen, Mark ; Seca, Hugo ; Sedej, Simon ; Segatori, Laura ; Segev, Nava ; Seglen, Per O ; Seguí-Simarro, Jose M ; Segura-Aguilar, Juan ; Seki, Ekihiro ; Seiliez, Iban ; Sell, Christian ; Semenkovich, Clay F ; Semenza, Gregg L ; Sen, Utpal ; Serra, Andreas L ; Serrano-Puebla, Ana ; Sesaki, Hiromi ; Setoguchi, Takao ; Settembre, Carmine ; Shacka, John J ; Shajahan-Haq, Ayesha N ; Shapiro, Irving M ; Sharma, Shweta ; She, Hua ; Shen, C-K James ; Shen, Chiung-Chyi ; Shen, Han-Ming ; Shen, Sanbing ; Shen, Weili ; Sheng, Rui ; Sheng, Xianyong ; Sheng, Zu-Hang ; Shepherd, Trevor G ; Shi, Junyan ; Shi, Qiang ; Shi, Qinghua ; Shi, Yuguang ; Shibutani, Shusaku ; Shibuya, Kenichi ; Shidoji, Yoshihiro ; Shieh, Jeng-Jer ; Shih, Chwen-Ming ; Shimada, Yohta ; Shimizu, Shigeomi ; Shin, Dong Wook ; Shinohara, Mari L ; Shintani, Michiko ; Shintani, Takahiro ; Shioi, Tetsuo ; Shirabe, Ken ; Shiri-Sverdlov, Ronit ; Shirihai, Orian ; Shore, Gordon C ; Shu, Chih-Wen ; Shukla, Deepak ; Sibirny, Andriy A ; Sica, Valentina ; Sigurdson, Christina J ; Sigurdsson, Einar M ; Sijwali, Puran Singh ; Sikorska, Beata ; Silveira, Wilian A ; Silvente-Poirot, Sandrine ; Silverman, Gary A ; Simak, Jan ; Simmet, Thomas ; Simon, Anna Katharina ; Simon, Hans-Uwe ; Simone, Cristiano ; Simons, Matias ; Simonsen, Anne ; Singh, Rajat ; Singh, Shivendra V ; Singh, Shrawan K ; Sinha, Debasish ; Sinha, Sangita ; Sinicrope, Frank A ; Sirko, Agnieszka ; Sirohi, Kapil ; Sishi, Balindiwe Jn ; Sittler, Annie ; Siu, Parco M ; Sivridis, Efthimios ; Skwarska, Anna ; Slack, Ruth ; Slaninová, Iva ; Slavov, Nikolai ; Smaili, Soraya S ; Smalley, Keiran Sm ; Smith, Duncan R ; Soenen, Stefaan J ; Soleimanpour, Scott A ; Solhaug, Anita ; Somasundaram, Kumaravel ; Son, Jin H ; Sonawane, Avinash ; Song, Chunjuan ; Song, Fuyong ; Song, Hyun Kyu ; Song, Ju-Xian ; Song, Wei ; Soo, Kai Y ; Sood, Anil K ; Soong, Tuck Wah ; Soontornniyomkij, Virawudh ; Sorice, Maurizio ; Sotgia, Federica ; Soto-Pantoja, David R ; Sotthibundhu, Areechun ; Sousa, Maria João ; Spaink, Herman P ; Span, Paul N ; Spang, Anne ; Sparks, Janet D ; Speck, Peter G ; Spector, Stephen A ; Spies, Claudia D ; Springer, Wolfdieter ; Clair, Daret St ; Stacchiotti, Alessandra ; Staels, Bart ; Stang, Michael T ; Starczynowski, Daniel T ; Starokadomskyy, Petro ; Steegborn, Clemens ; Steele, John W ; Stefanis, Leonidas ; Steffan, Joan ; Stellrecht, Christine M ; Stenmark, Harald ; Stepkowski, Tomasz M ; Stern, Stęphan T ; Stevens, Craig ; Stockwell, Brent R ; Stoka, Veronika ; Storchova, Zuzana ; Stork, Björn ; Stratoulias, Vassilis ; Stravopodis, Dimitrios J ; Strnad, Pavel ; Strohecker, Anne Marie ; Ström, Anna-Lena ; Stromhaug, Per ; Stulik, Jiri ; Su, Yu-Xiong ; Su, Zhaoliang ; Subauste, Carlos S ; Subramaniam, Srinivasa ; Sue, Carolyn M ; Suh, Sang Won ; Sui, Xinbing ; Sukseree, Supawadee ; Sulzer, David ; Sun, Fang-Lin ; Sun, Jiaren ; Sun, Jun ; Sun, Shi-Yong ; Sun, Yang ; Sun, Yi ; Sun, Yingjie ; Sundaramoorthy, Vinod ; Sung, Joseph ; Suzuki, Hidekazu ; Suzuki, Kuninori ; Suzuki, Naoki ; Suzuki, Tadashi ; Suzuki, Yuichiro J ; Swanson, Michele S ; Swanton, Charles ; Swärd, Karl ; Swarup, Ghanshyam ; Sweeney, Sean T ; Sylvester, Paul W ; Szatmari, Zsuzsanna ; Szegezdi, Eva ; Szlosarek, Peter W ; Taegtmeyer, Heinrich ; Tafani, Marco ; Taillebourg, Emmanuel ; Tait, Stephen Wg ; Takacs-Vellai, Krisztina ; Takahashi, Yoshinori ; Takáts, Szabolcs ; Takemura, Genzou ; Takigawa, Nagio ; Talbot, Nicholas J ; Tamagno, Elena ; Tamburini, Jerome ; Tan, Cai-Ping ; Tan, Lan ; Tan, Mei Lan ; Tan, Ming ; Tan, Yee-Joo ; Tanaka, Keiji ; 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Zhang, Donna D ; Zhang, Fan ; Zhang, Guo ; Zhang, Guo-Chang ; Zhang, Hao ; Zhang, Hong ; Zhang, Hong ; Zhang, Hongbing ; Zhang, Jian ; Zhang, Jian ; Zhang, Jiangwei ; Zhang, Jianhua ; Zhang, Jing-Pu ; Zhang, Li ; Zhang, Lin ; Zhang, Lin ; Zhang, Long ; Zhang, Ming-Yong ; Zhang, Xiangnan ; Zhang, Xu Dong ; Zhang, Yan ; Zhang, Yang ; Zhang, Yanjin ; Zhang, Yingmei ; Zhang, Yunjiao ; Zhao, Mei ; Zhao, Wei-Li ; Zhao, Xiaonan ; Zhao, Yan G ; Zhao, Ying ; Zhao, Yongchao ; Zhao, Yu-Xia ; Zhao, Zhendong ; Zhao, Zhizhuang J ; Zheng, Dexian ; Zheng, Xi-Long ; Zheng, Xiaoxiang ; Zhivotovsky, Boris ; Zhong, Qing ; Zhou, Guang-Zhou ; Zhou, Guofei ; Zhou, Huiping ; Zhou, Shu-Feng ; Zhou, Xu-Jie ; Zhu, Hongxin ; Zhu, Hua ; Zhu, Wei-Guo ; Zhu, Wenhua ; Zhu, Xiao-Feng ; Zhu, Yuhua ; Zhuang, Shi-Mei ; Zhuang, Xiaohong ; Ziparo, Elio ; Zois, Christos E ; Zoladek, Teresa ; Zong, Wei-Xing ; Zorzano, Antonio ; Zughaier, Susu M:
Guidelines for the use and interpretation of assays for monitoring autophagy. (3rd edition).
In: Autophagy. Bd. 12 (2016) Heft 1 . - S. 1-222.
DOI: https://doi.org/10.1080/15548627.2015.1100356

Suenkel, Benjamin ; Steegborn, Clemens:
Recombinant Preparation, Biochemical Analysis, and Structure Determination of Sirtuin Family Histone/Protein Deacylases.
In: Marmorstein, Ronen (Hrsg.): Enzymes of epigenetics. Part A. - Cambridge, MA : Academic Press, 2016 . - S. 183-208 . - (Methods in Enzymology ; 573 )
DOI: https://doi.org/10.1016/bs.mie.2015.12.004

Quinti, Luisa ; Casale, Malcolm ; Moniot, Sébastien ; Pais, Teresa Faria ; van Kanegan, Michael J. ; Kaltenbach, Linda S. ; Pallos, Judit ; Lim, Ryan G. ; Naidu, Sharadha Dayalan ; Runne, Heike ; Meisel, Lisa ; Rauf, Nazifa Abdul ; Leyfer, Dmitriy ; Maxwell, Michelle M. ; Saiah, Eddine ; Landers, John E. ; Luthi-Carter, Ruth ; Abagyan, Ruben ; Dinkova-Kostova, Albena T. ; Steegborn, Clemens ; Marsh, J. Lawrence ; Lo, Donald C. ; Thompson, Leslie M. ; Kazantsev, Aleksey G.:
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
In: Cell Chemical Biology. Bd. 23 (2016) Heft 7 . - S. 849-861.
DOI: https://doi.org/10.1016/j.chembiol.2016.05.015

Gertz, Melanie ; Steegborn, Clemens:
Using mitochondrial sirtuins as drug targets : disease implications and available compounds.
In: Cellular and Molecular Life Sciences. Bd. 73 (2016) . - S. 2871-2896.
DOI: https://doi.org/10.1007/s00018-016-2180-7

Simic, Zeljko ; Weiwad, Matthias ; Schierhorn, Angelika ; Steegborn, Clemens ; Schutkowski, Mike:
The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters.
In: ChemBioChem. Bd. 16 (2015) Heft 16 . - S. 2337-2347.
DOI: https://doi.org/10.1002/cbic.201500364

di Fruscia, Paolo ; Zacharioudakis, Emmanouil ; Liu, Chang ; Moniot, Sébastien ; Laohasinnarong, Sasiwan ; Khongkow, Mattaka ; Harrison, Ian F. ; Koltsida, Konstantina ; Reynolds, Christopher R. ; Schmidtkunz, Karin ; Jung, Manfred ; Chapman, Kathryn L. ; Steegborn, Clemens ; Dexter, David T. ; Sternberg, Michael J. E. ; Lam, Eric W.-F. ; Fuchter, Matthew J.:
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
In: ChemMedChem. Bd. 10 (2015) Heft 1 . - S. 69-82.
DOI: https://doi.org/10.1002/cmdc.201402431

Schweizer, Ulrich ; Steegborn, Clemens:
New insights into the structure and mechanism of iodothyronine deiodinases.
In: Journal of Molecular Endocrinology. Bd. 55 (2015) Heft 3 . - R37-R52.
DOI: https://doi.org/10.1530/JME-15-0156

Roessler, Claudia ; Tüting, Christian ; Meleshin, Marat ; Steegborn, Clemens ; Schutkowski, Mike:
A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases.
In: Journal of Medicinal Chemistry. Bd. 58 (2015) Heft 18 . - S. 7217-7223.
DOI: https://doi.org/10.1021/acs.jmedchem.5b00293

Fränzel, Benjamin ; Fischer, Frank ; Steegborn, Clemens ; Wolters, Dirk:
Proteinase K improves quantitative acylation studies.
In: Proteomics. Bd. 15 (2015) Heft 1 . - S. 44-47.
DOI: https://doi.org/10.1002/pmic.201400015

Rumpf, Tobias ; Schiedel, Matthias ; Karaman, Berin ; Roessler, Claudia ; North, Brian J. ; Lehotzky, Attila ; Oláh, Judit ; Ladwein, Kathrin I. ; Schmidtkunz, Karin ; Gajer, Markus ; Pannek, Martin ; Steegborn, Clemens ; Sinclair, David A. ; Gerhardt, Stefan ; Ovádi, Judit ; Schutkowski, Mike ; Sippl, Wolfgang ; Einsle, Oliver ; Jung, Manfred:
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
In: Nature Communications. Bd. 6 (2015) . - S. 6263.
DOI: https://doi.org/10.1038/ncomms7263

Chen, Xiqun ; Wales, Pauline ; Quinti, Luisa ; Zuo, Fuxing ; Moniot, Sébastien ; Herisson, Fanny ; Rauf, Nazifa Abdul ; Wang, Hua ; Silverman, Richard B. ; Ayata, Cenk ; Maxwell, Michelle M. ; Steegborn, Clemens ; Schwarzschild, Michael A. ; Outeiro, Tiago F. ; Kazantsev, Aleksey G.:
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
In: PLoS One. Bd. 10 (2015) Heft 1 . - No. e0116919.
DOI: https://doi.org/10.1371/journal.pone.0116919

Polletta, Lucia ; Vernucci, Enza ; Carnevale, Ilaria ; Arcangeli, Tania ; Rotili, Dante ; Palmerio, Silvia ; Steegborn, Clemens ; Nowak, Theresa ; Schutkowski, Mike ; Pellegrini, Laura ; Sansone, Luigi ; Villanova, Lidia ; Runci, Alessandra ; Pucci, Bruna ; Morgante, Emanuela ; Fini, Massimo ; Mai, Antonello ; Russo, Matteo A. ; Tafani, Marco:
SIRT5 regulation of ammonia-induced autophagy and mitophagy.
In: Autophagy. Bd. 11 (2015) Heft 2 . - S. 253-270.
DOI: https://doi.org/10.1080/15548627.2015.1009778

Schweizer, Ulrich ; Steegborn, Clemens:
Thyroid hormones : From Crystal Packing to Activity to Reactivity.
In: Angewandte Chemie International Edition. Bd. 54 (2015) Heft 44 . - S. 12856-12858.
DOI: https://doi.org/10.1002/anie.201506919

Banerjee, Arka ; Adolph, Ramona S. ; Gopalakrishnapai, Jayashree ; Kleinbölting, Silke ; Emmerich, Christiane ; Steegborn, Clemens ; Visweswariah, Sandhya S.:
A Universal Stress Protein (USP) in Mycobacteria binds cAMP.
In: The Journal of Biological Chemistry. Bd. 290 (2015) Heft 20 . - S. 12731-12743.
DOI: https://doi.org/10.1074/jbc.M115.644856

Schutkowski, Mike ; Fischer, Frank ; Roessler, Claudia ; Steegborn, Clemens:
New assays and approaches for discovery and design of Sirtuin modulators.
In: Expert Opinion on Drug Discovery. Bd. 9 (Februar 2014) Heft 2 . - S. 183-199.
DOI: https://doi.org/10.1517/17460441.2014.875526

Schweizer, Ulrich ; Schlicker, Christine ; Braun, Doreen ; Köhrle, Josef ; Steegborn, Clemens:
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 111 (2014) Heft 29 . - S. 10526-10531.
DOI: https://doi.org/10.1073/pnas.1323873111

Kleinbölting, Silke ; Diaz, Ana ; Moniot, Sébastien ; van den Heuvel, Joop ; Weyand, Michael ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 111 (2014) Heft 10 . - S. 3727-3732.
DOI: https://doi.org/10.1073/pnas.1322778111

Suhre, Michael H. ; Scheibel, Thomas ; Steegborn, Clemens ; Gertz, Melanie:
Crystallization and preliminary X-ray diffractionanalysis of proximal thread matrix protein 1(PTMP1) from Mytilus galloprovincialis.
In: Acta Crystallographica Section F. Bd. 70 (2014) Heft 6 . - S. 769-772.
DOI: https://doi.org/10.1107/S2053230X14006165

Kleinbölting, Silke ; van den Heuvel, Joop ; Kambach, Christian ; Weyand, Michael ; Leipelt, Martina ; Steegborn, Clemens:
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase.
In: Acta Crystallographica Section F. Bd. 70 (2014) Heft 4 . - S. 467-469.
DOI: https://doi.org/10.1107/S2053230X14004014

Kleinbölting, Silke ; van den Heuvel, Joop ; Steegborn, Clemens:
Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution.
In: The FEBS Journal. Bd. 281 (2014) Heft 18 . - S. 4151-4164.
DOI: https://doi.org/10.1111/febs.12913

Suhre, Michael H. ; Gertz, Melanie ; Steegborn, Clemens ; Scheibel, Thomas:
Structural and functional features of a collagen-binding matrix protein from the mussel byssus.
In: Nature Communications. Bd. 5 (2014) . - 3392.
DOI: https://doi.org/10.1038/ncomms4392

Steegborn, Clemens:
Structure, mechanism, and regulation of soluble adenylyl cyclases : similarities and differences to transmembrane adenylyl cyclases.
In: Biochimica et Biophysica Acta : Molecular Basis of Disease. Bd. 1842 (2014) Heft 12, Part B . - S. 2535-2547.
DOI: https://doi.org/10.1016/j.bbadis.2014.08.012

Roessler, Claudia ; Nowak, Theresa ; Pannek, Martin ; Gertz, Melanie ; Nguyen, Giang Thi Tuyet ; Scharfe, Michael ; Born, Ilona ; Sippl, Wolfgang ; Steegborn, Clemens ; Schutkowski, Mike:
Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors.
In: Angewandte Chemie International Edition. Bd. 53 (2014) Heft 40 . - S. 10728-10732.
DOI: https://doi.org/10.1002/anie.201402679

Rauh, David ; Fischer, Frank ; Gertz, Melanie ; Lakshminarasimhan, Mahadevan ; Bergbrede, Tim ; Aladini, Firouzeh ; Kambach, Christian ; Becker, Christian F. W. ; Zerweck, Johannes ; Schutkowski, Mike ; Steegborn, Clemens:
An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.
In: Nature Communications. Bd. 4 (2013) . - S. 2327.
DOI: https://doi.org/10.1038/ncomms3327

Moniot, Sébastien ; Schutkowski, Mike ; Steegborn, Clemens:
Crystal structure analysis of human Sirt2 and its ADP-ribose complex.
In: Journal of Structural Biology. Bd. 182 (2013) Heft 2 . - S. 136-143.
DOI: https://doi.org/10.1016/j.jsb.2013.02.012

Nguyen, Giang Thi Tuyet ; Gertz, Melanie ; Steegborn, Clemens:
Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism.
In: Chemistry & Biology. Bd. 20 (2013) Heft 11 . - S. 1375-1385.
DOI: https://doi.org/10.1016/j.chembiol.2013.09.019

Gertz, Melanie ; Fischer, Frank ; Nguyen, Giang Thi Tuyet ; Lakshminarasimhan, Mahadevan ; Schutkowski, Mike ; Weyand, Michael ; Steegborn, Clemens:
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 110 (2013) Heft 30 . - S. E2772-E2781.
DOI: https://doi.org/10.1073/pnas.1303628110

Suenkel, Benjamin ; Fischer, Frank ; Steegborn, Clemens:
Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.
In: Bioorganic & Medicinal Chemistry Letters. Bd. 23 (2013) Heft 1 . - S. 143-146.
DOI: https://doi.org/10.1016/j.bmcl.2012.10.136

Lakshminarasimhan, Mahadevan ; Curth, Ute ; Moniot, Sébastien ; Mosalaganti, Shyamal ; Raunser, Stefan ; Steegborn, Clemens:
Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.
In: Bioscience Reports. Bd. 33 (2013) Heft 3 . - S. 395-404.
DOI: https://doi.org/10.1042/BSR20120121

Lakshminarasimhan, Mahadevan ; Rauh, David ; Schutkowski, Mike ; Steegborn, Clemens:
Sirt1 activation by resveratrol is substrate sequence-selective.
In: Aging. Bd. 5 (2013) Heft 3 . - S. 151-154.

Laurent, Gaëlle ; German, Natalie J. ; Saha, Asish K. ; de Boer, Vincent C. J. ; Davies, Michael ; Koves, Timothy R. ; Dephoure, Noah ; Fischer, Frank ; Boanca, Gina ; Vaitheesvaran, Bhavapriya ; Lovitch, Scott B. ; Sharpe, Arlene H. ; Kurland, Irwin J. ; Steegborn, Clemens ; Gygi, Steven P. ; Muoio, Deborah M. ; Ruderman, Neil B. ; Haigis, Marcia C.:
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
In: Molecular Cell. Bd. 50 (2013) Heft 5 . - S. 686-698.
DOI: https://doi.org/10.1016/j.molcel.2013.05.012

Nguyen, Giang Thi Tuyet ; Schäfer, Susanne ; Gertz, Melanie ; Weyand, Michael ; Steegborn, Clemens:
Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism.
In: Acta Crystallographica Section D. Bd. 69 (2013) Heft 8 . - S. 1423-1432.
DOI: https://doi.org/10.1107/S0907444913015448

Topal, Hüsnü ; Fulcher, Nanette B. ; Bitterman, Jacob ; Salazar, Eric ; Buck, Jochen ; Levin, Lonny R. ; Cann, Martin J. ; Wolfgang, Matthew C. ; Steegborn, Clemens:
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.
In: Journal of Molecular Biology. Bd. 416 (2012) Heft 2 . - S. 271-286.
DOI: https://doi.org/10.1016/j.jmb.2011.12.045

Middelhaufe, Sabine ; Leipelt, Martina ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Identification of a haem domain in human soluble adenylate cyclase.
In: Bioscience Reports. Bd. 32 (2012) Heft 5 . - S. 491-499.
DOI: https://doi.org/10.1042/BSR20120051

Gertz, Melanie ; Nguyen, Giang Thi Tuyet ; Fischer, Frank ; Suenkel, Benjamin ; Schlicker, Christine ; Fränzel, Benjamin ; Tomaschewski, Jana ; Aladini, Firouzeh ; Becker, Christian F. W. ; Wolters, Dirk ; Steegborn, Clemens:
A molecular mechanism for direct sirtuin activation by resveratrol.
In: PLoS One. Bd. 7 (2012) Heft 11 . - No. e49761.
DOI: https://doi.org/10.1371/journal.pone.0049761

Fischer, Frank ; Gertz, Melanie ; Suenkel, Benjamin ; Lakshminarasimhan, Mahadevan ; Schutkowski, Mike ; Steegborn, Clemens:
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.
In: PLoS One. Bd. 7 (2012) Heft 9 . - No. e45098.
DOI: https://doi.org/10.1371/journal.pone.0045098

Moniot, Sébastien ; Weyand, Michael ; Steegborn, Clemens:
Structures, substrates, and regulators of Mammalian sirtuins : opportunities and challenges for drug development.
In: Frontiers in Pharmacology. Bd. 3 (2012) . - 16.
DOI: https://doi.org/10.3389/fphar.2012.00016

Russwurm, Michael ; Schlicker, Christine ; Weyand, Michael ; Koesling, Doris ; Steegborn, Clemens:
Crystal structure of the GAF-B domain from human phosphodiesterase 5.
In: Proteins. Bd. 79 (2011) Heft 5 . - S. 1682-1687.
DOI: https://doi.org/10.1002/prot.22989

Lakshminarasimhan, Mahadevan ; Steegborn, Clemens:
Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets.
In: Experimental Gerontology. Bd. 46 (2011) Heft 2-3 . - S. 174-177.
DOI: https://doi.org/10.1016/j.exger.2010.08.024

Schlicker, Christine ; Boanca, Gina ; Lakshminarasimhan, Mahadevan ; Steegborn, Clemens:
Structure-based development of novel sirtuin inhibitors.
In: Aging. Bd. 3 (2011) Heft 9 . - S. 852-872.

Acin-Perez, Rebeca ; Russwurm, Michael ; Günnewig, Kathrin ; Gertz, Melanie ; Zoidl, Georg ; Ramos, Lavoisier ; Buck, Jochen ; Levin, Lonny R. ; Rassow, Joachim ; Manfredi, Giovanni ; Steegborn, Clemens:
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.
In: The Journal of Biological Chemistry. Bd. 286 (2011) Heft 35 . - S. 30423-30432.
DOI: https://doi.org/10.1074/jbc.M111.266379

Hall, Rebecca A. ; de Sordi, Luisa ; Maccallum, Donna M. ; Topal, Hüsnü ; Eaton, Rebecca ; Bloor, James W. ; Robinson, Gary K. ; Levin, Lonny R. ; Buck, Jochen ; Wang, Yue ; Gow, Neil A .R. ; Steegborn, Clemens ; Mühlschlegel, Fritz A.:
CO₂ acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
In: PLoS Pathogens. Bd. 6 (2010) Heft 11 . - No. e1001193.
DOI: https://doi.org/10.1371/journal.ppat.1001193

Baur, Joseph A. ; Chen, Danica ; Chini, Eduardo N. ; Chua, Katrin F. ; Cohen, Haim Y. ; de Cabo, Rafael ; Deng, Chuxia ; Dimmeler, Stefanie ; Gius, David ; Guarente, Leonard P. ; Helfand, Stephen L. ; Imai, Shin-Ichiro ; Itoh, Hiroshi ; Kadowaki, Takashi ; Koya, Daisuke ; Leeuwenburgh, Christiaan ; McBurney, Michael ; Nabeshima, Yo-Ichi ; Neri, Christian ; Oberdoerffer, Philipp ; Pestell, Richard G. ; Rogina, Blanka ; Sadoshima, Junichi ; Sartorelli, Vittorio ; Serrano, Manuel ; Sinclair, David A. ; Steegborn, Clemens ; Tatar, Marc ; Tissenbaum, Heidi A. ; Tong, Qiang ; Tsubota, Kazuo ; Vaquero, Alejandro ; Verdin, Eric:
Dietary restriction : standing up for sirtuins.
In: Science. Bd. 329 (2010) Heft 5995 . - S. 1012-1013.
DOI: https://doi.org/10.1126/science.329.5995.1012

Gertz, Melanie ; Steegborn, Clemens:
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
In: Biochimica et Biophysica Acta : Proteins and Proteomics. Bd. 1804 (2010) Heft 8 . - S. 1658-1665.
DOI: https://doi.org/10.1016/j.bbapap.2009.09.011

Gertz, Melanie ; Steegborn, Clemens:
The Lifespan-Regulator p66Shc in mitochondria : redox enzyme or redox sensor?
In: Antioxidants & Redox Signaling. Bd. 13 (2010) Heft 9 . - S. 1417-1428.
DOI: https://doi.org/10.1089/ars.2010.3147

Gertz, Melanie ; Steegborn, Clemens:
The mitochondrial apoptosis pathway and p66Shc : a regulatory redox enzyme or an adapter protein snuggling around?
In: Cell Cycle. Bd. 9 (2010) Heft 22 . - S. 4425-4426.
DOI: https://doi.org/10.4161/cc.9.22.14053

Innocenti, Alessio ; Hall, Rebecca A. ; Schlicker, Christine ; Scozzafava, Andrea ; Steegborn, Clemens ; Mühlschlegel, Fritz A. ; Supuran, Claudiu T.:
Carbonic anhydrase inhibitors : Inhibition and homology modeling studies of the fungal β-carbonic anhydrase from Candida albicans with sulfonamides.
In: Bioorganic & Medicinal Chemistry. Bd. 17 (2009) Heft 13 . - S. 4503-4509.
DOI: https://doi.org/10.1016/j.bmc.2009.05.002

Steegborn, Clemens ; Ohndorf, Uta-Maria ; Schlicker, Christine:
Crystallographic studies on carbonic anhydrases from fungal pathogens for structure-assisted drug development.
In: Supuran, Claudiu T. ; Winum, J.-Y. (Hrsg.): Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural and Disease Applications. - Hoboken, NJ : Wiley, 2009 . - S. 323-334 . - (Wiley Series in Drug Discovery and Development )

Gertz, Melanie ; Fischer, Frank ; Leipelt, Martina ; Wolters, Dirk ; Steegborn, Clemens:
Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc.
In: Aging. Bd. 1 (2009) Heft 2 . - S. 254-265.

Schlicker, Christine ; Hall, Rebecca A. ; Vullo, Daniela ; Middelhaufe, Sabine ; Gertz, Melanie ; Supuran, Claudiu T. ; Mühlschlegel, Fritz A. ; Steegborn, Clemens:
Structure and inhibition of the CO₂-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.
In: Journal of Molecular Biology. Bd. 385 (2009) Heft 4 . - S. 1207-1220.
DOI: https://doi.org/10.1016/j.jmb.2008.11.037

Gertz, Melanie ; Fischer, Frank ; Wolters, Dirk ; Steegborn, Clemens:
Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 105 (2008) Heft 15 . - S. 5705-5709.
DOI: https://doi.org/10.1073/pnas.0800691105

Innocenti, Alessio ; Mühlschlegel, Fritz A. ; Hall, Rebecca A. ; Steegborn, Clemens ; Scozzafava, Andrea ; Supuran, Claudiu T.:
Carbonic anhydrase inhibitors: inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
In: Bioorganic & Medicinal Chemistry Letters. Bd. 18 (2008) Heft 18 . - S. 5066-5070.
DOI: https://doi.org/10.1016/j.bmcl.2008.07.122

Rauch, Annika ; Leipelt, Martina ; Russwurm, Michael ; Steegborn, Clemens:
Crystal structure of the guanylyl cyclase Cya2.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 105 (2008) Heft 41 . - S. 15720-15725.
DOI: https://doi.org/10.1073/pnas.0808473105

Tammenkoski, Marko ; Koivula, Katja ; Cusanelli, Emilio ; Zollo, Massimo ; Steegborn, Clemens ; Baykov, Alexander A. ; Lahti, Reijo:
Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase.
In: Biochemistry. Bd. 47 (2008) Heft 36 . - S. 9707-9713.
DOI: https://doi.org/10.1021/bi8010847

Garzia, Livia ; D'Angelo, A. ; Amoresano, A. ; Knauer, Shirley K. ; Cirulli, C. ; Campanella, C. ; Stauber, R. H. ; Steegborn, Clemens ; Iolascon, A. ; Zollo, Massimo:
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility.
In: Oncogene. Bd. 27 (2008) . - S. 1853-1864.
DOI: https://doi.org/10.1038/sj.onc.1210822

Schlicker, Christine ; Rauch, Annika ; Hess, Ken C. ; Kachholz, Barbara ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Structure-based development of novel adenylyl cyclase inhibitors.
In: Journal of Medicinal Chemistry. Bd. 51 (2008) Heft 15 . - S. 4456-4464.
DOI: https://doi.org/10.1021/jm800481q

Schlicker, Christine ; Gertz, Melanie ; Papatheodorou, Panagiotis ; Kachholz, Barbara ; Becker, Christian F. W. ; Steegborn, Clemens:
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
In: Journal of Molecular Biology. Bd. 382 (2008) Heft 3 . - S. 790-801.
DOI: https://doi.org/10.1016/j.jmb.2008.07.048

Middelhaufe, Sabine ; Garzia, Livia ; Ohndorf, Uta-Maria ; Kachholz, Barbara ; Zollo, Massimo ; Steegborn, Clemens:
Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain.
In: Biochemical Journal. Bd. 407 (2007) Heft 2 . - S. 199-205.
DOI: https://doi.org/10.1042/BJ20070408

Mannherz, Hans Georg ; Ballweber, Edda ; Galla, Marco ; Villard, Sylvie ; Granier, Claude ; Steegborn, Clemens ; Schmidtmann, Anja ; Jaquet, Kornelia ; Pope, Brian ; Weeds, Alan G.:
Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array : evidence for a second binding site on monomeric actin.
In: Journal of Molecular Biology. Bd. 366 (2007) Heft 3 . - S. 745-755.
DOI: https://doi.org/10.1016/j.jmb.2006.11.100

Mogensen, Estelle Geweiss ; Janbon, Guilhem ; Chaloupka, James ; Steegborn, Clemens ; Fu, Man Shun ; Moyrand, Frédérique ; Klengel, Torsten ; Pearson, David S. ; Geeves, Michael A. ; Buck, Jochen ; Levin, Lonny R. ; Mühlschlegel, Fritz A.:
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1.
In: Eukaryotic Cell. Bd. 5 (Januar 2006) Heft 1 . - S. 103-111.
DOI: https://doi.org/10.1128/EC.5.1.103-111.2006

Kamenetsky, Margarita ; Middelhaufe, Sabine ; Bank, Erin M. ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Molecular details of cAMP generation in mammalian cells : a tale of two systems.
In: Journal of Molecular Biology. Bd. 362 (2006) Heft 4 . - S. 623-639.
DOI: https://doi.org/10.1016/j.jmb.2006.07.045

Steegborn, Clemens ; Litvin, Tatiana N. ; Levin, Lonny R. ; Buck, Jochen ; Wu, Hao:
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment.
In: Nature Structural & Molecular Biology. Bd. 12 (Januar 2005) Heft 1 . - S. 32-37.
DOI: https://doi.org/10.1038/nsmb880

Steegborn, Clemens ; Litvin, Tatiana N. ; Hess, Kenneth C. ; Capper, Austin B. ; Taussig, Ronald ; Buck, Jochen ; Levin, Lonny R. ; Wu, Hao:
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen.
In: The Journal of Biological Chemistry. Bd. 280 (2005) Heft 36 . - S. 31754-31759.
DOI: https://doi.org/10.1074/jbc.M507144200

Ye, Hong ; Chen, Tzu-Chao ; Xu, Xiaohui ; Pennycooke, Micha ; Wu, Hao ; Steegborn, Clemens:
Crystal structure of the putative adapter protein MTH1859.
In: Journal of Structural Biology. Bd. 148 (2004) Heft 2 . - S. 251-256.
DOI: https://doi.org/10.1016/j.jsb.2004.06.004

Augustin, Martin A. ; Reichert, Andreas S. ; Betat, Heike ; Huber, Robert ; Mörl, Mario ; Steegborn, Clemens:
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization.
In: Journal of Molecular Biology. Bd. 328 (2003) Heft 5 . - S. 985-994.
DOI: https://doi.org/10.1016/S0022-2836(03)00381-4

Messerschmidt, Albrecht ; Worbs, Michael ; Steegborn, Clemens ; Wahl, Markus C. ; Huber, Robert ; Laber, Bernd ; Clausen, Tim:
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine ɣ-lyase from yeast and intrafamiliar structure comparison.
In: Biological Chemistry. Bd. 384 (2003) Heft 3 . - S. 373-386.
DOI: https://doi.org/10.1515/BC.2003.043

Xu, Guozhou ; Rich, Rebecca L. ; Steegborn, Clemens ; Min, Tongpil ; Huang, Yihua ; Myszka, David G. ; Wu, Hao:
Mutational analyses of the p35-caspase interaction : A bowstring kinetic model of caspase inhibition by p35.
In: The Journal of Biological Chemistry. Bd. 278 (2003) Heft 7 . - S. 5455-5461.
DOI: https://doi.org/10.1074/jbc.M211607200

Stabler, Sally P. ; Steegborn, Clemens ; Wahl, Markus C. ; Oliveriusova, Jana ; Kraus, Jan P. ; Allen, Robert H. ; Wagner, Conrad ; Mudd, S. Harvey:
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.
In: Metabolism. Bd. 51 (2002) Heft 8 . - S. 981-988.
DOI: https://doi.org/10.1053/meta.2002.34017

Rossoll, Wilfried ; Kröning, Ann-Kathrin ; Ohndorf, Uta-Maria ; Steegborn, Clemens ; Jablonka, Sibylle ; Sendtner, Michael:
Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?
In: Human Molecular Genetics. Bd. 11 (2002) Heft 1 . - S. 93-105.
DOI: https://doi.org/10.1093/hmg/11.1.93

Steegborn, Clemens ; Laber, Bernd ; Messerschmidt, Albrecht ; Huber, Robert ; Clausen, Tim:
Crystal structures of cystathionine γ-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor.
In: Journal of Molecular Biology. Bd. 311 (2001) Heft 4 . - S. 789-801.
DOI: https://doi.org/10.1006/jmbi.2001.4880

Ohndorf, Uta-Maria ; Steegborn, Clemens ; Knijff, Rainer ; Sondermann, Peter:
Contributions of the individual domains in human La protein to its RNA 3'-end binding activity.
In: The Journal of Biological Chemistry. Bd. 276 (2001) Heft 29 . - S. 27188-27196.
DOI: https://doi.org/10.1074/jbc.M102891200

Dorowski, Anja ; Hofmann, Andreas ; Steegborn, Clemens ; Boicu, Marius ; Huber, Robert:
Crystal structure of paprika ferredoxin-NADP+ reductase : Implications for the electron transfer pathway.
In: The Journal of Biological Chemistry. Bd. 276 (2001) Heft 12 . - S. 9253-9263.
DOI: https://doi.org/10.1074/jbc.M004576200

Steegborn, Clemens ; Danot, Olivier ; Huber, Robert ; Clausen, Tim:
Crystal structure of transcription factor MalT domain III : a novel helix repeat fold implicated in regulated oligomerization.
In: Structure. Bd. 9 (2001) Heft 11 . - S. 1051-1060.
DOI: https://doi.org/10.1016/S0969-2126(01)00665-7

Steegborn, Clemens ; Schneider-Hassloff, Henriette ; Zeeb, Markus ; Balbach, Jochen:
Cooperativity of a protein folding reaction probed at multiple chain positions by real-time 2D NMR spectroscopy.
In: Biochemistry. Bd. 39 (2000) Heft 27 . - S. 7910-7919.
DOI: https://doi.org/10.1021/bi000270u

Clausen, Tim ; Kaiser, Jens T. ; Steegborn, Clemens ; Huber, Robert ; Kessler, Dorothea:
Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 97 (2000) Heft 8 . - S. 3856-3861.
DOI: https://doi.org/10.1073/pnas.97.8.3856

Schreiber, Valerie ; Steegborn, Clemens ; Clausen, Tim ; Boos, Winfried ; Richet, Evelyne:
A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors.
In: Molecular Microbiology. Bd. 35 (2000) Heft 4 . - S. 765-776.
DOI: https://doi.org/10.1046/j.1365-2958.2000.01747.x

Clausen, Tim ; Schlegel, Anja ; Peist, Ralf ; Schneider, Eva ; Steegborn, Clemens ; Chang, Yuh-Shin ; Haase, Andrea ; Bourenkov, Gleb P. ; Bartunik, Hans D. ; Boos, Winfried:
X-ray structure of MalY from Escherichia coli: a pyridoxal 5'-phosphate-dependent enzyme acting as a modulator in mal gene expression.
In: The EMBO Journal. Bd. 19 (2000) Heft 5 . - S. 831-842.
DOI: https://doi.org/10.1093/emboj/19.5.831

Clausen, Tim ; Wahl, Markus C. ; Messerschmidt, Albrecht ; Huber, Robert ; Fuhrmann, Jens C. ; Laber, Bernd ; Streber, Wolfgang ; Steegborn, Clemens:
Cloning, purification and characterisation of cystathionine γ-Synthase from Nicotiana tabacum.
In: Biological Chemistry. Bd. 380 (1999) Heft 10 . - S. 1237-1242.
DOI: https://doi.org/10.1515/BC.1999.157

Steegborn, Clemens ; Messerschmidt, Albrecht ; Laber, Bernd ; Streber, Wolfgang ; Huber, Robert ; Clausen, Tim:
The crystal structure of cystathionine γ-synthase from Nicotiana tabacum reveals its substrate and reaction specificity.
In: Journal of Molecular Biology. Bd. 290 (1999) Heft 5 . - S. 983-996.
DOI: https://doi.org/10.1006/jmbi.1999.2935

Balbach, Jochen ; Steegborn, Clemens ; Schindler, Thomas ; Schmid, Franz X.:
A protein folding intermediate of ribonuclease T₁ characterized at high resolution by 1D and 2D real-time NMR spectroscopy.
In: Journal of Molecular Biology. Bd. 285 (1999) Heft 2 . - S. 829-842.
DOI: https://doi.org/10.1006/jmbi.1998.2364

Steegborn, Clemens ; Clausen, Tim ; Sondermann, Peter ; Jacob, Uwe ; Worbs, Michael ; Marinkovic, Snezan ; Huber, Robert ; Wahl, Markus C.:
Kinetics and inhibition of recombinant human cystathionine gamma-lyase : Toward the rational control of transsulfuration.
In: The Journal of Biological Chemistry. Bd. 274 (1999) Heft 18 . - S. 12675-12684.
DOI: https://doi.org/10.1074/jbc.274.18.12675

Steegborn, Clemens ; Skládal, Petr:
Construction and characterization of the direct piezoelectric immunosensor for atrazine operating in solution.
In: Biosensors and Bioelectronics. Bd. 12 (1997) Heft 1 . - S. 19-27.
DOI: https://doi.org/10.1016/0956-5663(96)89086-5

Sprinzl, Mathias ; Steegborn, Clemens ; Hübel, Frank ; Steinberg, Sergey:
Compilation of tRNA sequences and sequences of tRNA genes.
In: Nucleic Acids Research. Bd. 24 (1 Januar 1996) Heft 1 . - S. 68-72.
DOI: https://doi.org/10.1093/nar/24.1.68

Metzger, Armin U. ; Schindler, Thomas ; Willbold, Dieter ; Kraft, Margot ; Steegborn, Clemens ; Volkmann, Andrea ; Frank, Rainer W. ; Rösch, Paul:
Structural rearrangements on HIV-1 Tat (32-72) TAR complex formation.
In: FEBS Letters. Bd. 384 (1996) Heft 3 . - S. 255-259.
DOI: https://doi.org/10.1016/0014-5793(96)00314-6