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CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans.

Title data

Hall, Rebecca A. ; de Sordi, Luisa ; Maccallum, Donna M. ; Topal, Hüsnü ; Eaton, Rebecca ; Bloor, James W. ; Robinson, Gary K. ; Levin, Lonny R. ; Buck, Jochen ; Wang, Yue ; Gow, Neil A .R. ; Steegborn, Clemens ; Mühlschlegel, Fritz A.:
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
In: PLoS Pathogens. Vol. 6 (2010) Issue 11 . - e1001193.
ISSN 1553-7374
DOI: https://doi.org/10.1371/journal.ppat.1001193

Abstract in another language

When colonising host-niches or non-animated medical devices, individual cells of the fungal pathogen Candida albicans expand into significant biomasses. Here we show that within such biomasses, fungal metabolically generated CO(2) acts as a communication molecule promoting the switch from yeast to filamentous growth essential for C. albicans pathology. We find that CO(2)-mediated intra-colony signalling involves the adenylyl cyclase protein (Cyr1p), a multi-sensor recently found to coordinate fungal responses to serum and bacterial peptidoglycan. We further identify Lys 1373 as essential for CO(2)/bicarbonate regulation of Cyr1p. Disruption of the CO(2)/bicarbonate receptor-site interferes selectively with C. albicans filamentation within fungal biomasses. Comparisons between the Drosophila melanogaster infection model and the mouse model of disseminated candidiasis, suggest that metabolic CO(2) sensing may be important for initial colonisation and epithelial invasion. Our results reveal the existence of a gaseous Candida signalling pathway and its molecular mechanism and provide insights into an evolutionary conserved CO(2)-signalling system.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: PubMed-ID: 18596626
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Clemens Steegborn
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 17 Apr 2015 09:18
Last Modified: 11 Jun 2015 12:29
URI: https://eref.uni-bayreuth.de/id/eprint/10376