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Sirt1 activation by resveratrol is substrate sequence-selective.

Title data

Lakshminarasimhan, Mahadevan ; Rauh, David ; Schutkowski, Mike ; Steegborn, Clemens:
Sirt1 activation by resveratrol is substrate sequence-selective.
In: Aging. Vol. 5 (March 2013) Issue 3 . - pp. 151-154.
ISSN 1945-4589

Official URL: Volltext

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Abstract in another language

Sirtuins are protein deacetylases used as therapeutic targets. Pharmacological Sirt1 activation has been questioned since the in vitro activator resveratrol failed to stimulate deacetylation of several physiological substrates. We tested the influence of substrate sequence by analyzing resveratrol effects on Sirt1-dependent deacetylation of 6802 physiological acetylation sites using peptide microarrays. Resveratrol stimulated deacetylation of a small set of sites and inhibited deacetylation of another set, whereas most substrates were hardly affected. Solution assays confirmed these substrate categories, and statistical analysis revealed their sequence features. Our results reveal substrate sequence dependence for Sirt1 modulation and suggest substrates contributing to resveratrol effects.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: PubMed-ID: 15734680
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Clemens Steegborn
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 20 Apr 2015 12:13
Last Modified: 14 Apr 2016 06:22
URI: https://eref.uni-bayreuth.de/id/eprint/10391