Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.

Title data

Laurent, Gaëlle ; German, Natalie J. ; Saha, Asish K. ; de Boer, Vincent C. J. ; Davies, Michael ; Koves, Timothy R. ; Dephoure, Noah ; Fischer, Frank ; Boanca, Gina ; Vaitheesvaran, Bhavapriya ; Lovitch, Scott B. ; Sharpe, Arlene H. ; Kurland, Irwin J. ; Steegborn, Clemens ; Gygi, Steven P. ; Muoio, Deborah M. ; Ruderman, Neil B. ; Haigis, Marcia C.:
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
In: Molecular Cell. Vol. 50 (6 June 2013) Issue 5 . - pp. 686-698.
ISSN 1097-4164
DOI: https://doi.org/10.1016/j.molcel.2013.05.012

Abstract in another language

Lipid metabolism is tightly controlled by the nutritional state of the organism. Nutrient-rich conditions increase lipogenesis, whereas nutrient deprivation promotes fat oxidation. In this study, we identify the mitochondrial sirtuin, SIRT4, as a regulator of lipid homeostasis. SIRT4 is active in nutrient-replete conditions to repress fatty acid oxidation while promoting lipid anabolism. SIRT4 deacetylates and inhibits malonyl CoA decarboxylase (MCD), an enzyme that produces acetyl CoA from malonyl CoA. Malonyl CoA provides the carbon skeleton for lipogenesis and also inhibits fat oxidation. Mice lacking SIRT4 display elevated MCD activity and decreased malonyl CoA in skeletal muscle and white adipose tissue. Consequently, SIRT4 KO mice display deregulated lipid metabolism, leading to increased exercise tolerance and protection against diet-induced obesity. In sum, this work elucidates SIRT4 as an important regulator of lipid homeostasis, identifies MCD as a SIRT4 target, and deepens our understanding of the malonyl CoA regulatory axis.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: PubMed-ID: 23077570
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Clemens Steegborn
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 20 Apr 2015 12:22
Last Modified: 20 Apr 2015 12:22
URI: https://eref.uni-bayreuth.de/id/eprint/10421