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Multi-tasking phytochelatin synthases

Title data

Clemens, Stephan ; Peršoh, Derek:
Multi-tasking phytochelatin synthases.
In: Plant Science. Vol. 177 (2009) Issue 4 . - pp. 266-271.
ISSN 1873-2259
DOI: https://doi.org/10.1016/j.plantsci.2009.06.008

Abstract in another language

Phytochelatins are essential for cadmium and arsenic detoxification in plants, some fungi, and animals. It is mysterious, that the responsible enzymes, phytochelatin synthases (PCS), are constitutively expressed and so widespread in nature. Phylogenetic analysis indicates multiple horizontal transfers of PCS genes, but a bacterial origin appears unlikely. Differences between bacterial and eukaryotic PCS proteins in structure and activity had indicated bi-functionality of phytochelatin synthases as peptidases and transpeptidases. Recent observations indicate that PCS indeed serve physiological functions that most likely are much more prevalent than cadmium or arsenic detoxification. First, PCS-deficient Arabidopsis thaliana mutants are hypersensitive to zinc suggesting a role of phytochelatin synthesis, i.e. the formation of metal-binding peptides from glutathione in a transpeptidase reaction, in Zn homeostasis. Second, these mutants are also impaired in defense responses conferring resistance to incompatible pathogens (= nonhost resistance). The latter is hypothesized to be attributable to an involvement of PCS as a peptidase in indole glucosinolate metabolism. Possibly, micronutrient homeostasis and nonhost resistance are closely connected as PCS are not the only proteins involved in both processes.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: BAYCEER74707
BAYCEER71824
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Plant Physiology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Plant Physiology > Chair Plant Physiology - Univ.-Prof. Dr. Stephan Clemens
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Professorship Mycology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Professorship Mycology > Professorship Mycology - Univ.-Prof. Dr. Gerhard Rambold
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center of Ecology and Environmental Research- BayCEER
Result of work at the UBT: Yes
DDC Subjects: 500 Science
Date Deposited: 05 May 2015 12:10
Last Modified: 30 Jun 2015 06:51
URI: https://eref.uni-bayreuth.de/id/eprint/12807