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Biofabrication of Cell-Loaded 3D Spider Silk Constructs

Title data

Schacht, Kristin ; Jüngst, Tomasz ; Schweinlin, Matthias ; Ewald, Andrea ; Groll, Jürgen ; Scheibel, Thomas:
Biofabrication of Cell-Loaded 3D Spider Silk Constructs.
In: Angewandte Chemie International Edition. Vol. 54 (13 February 2015) Issue 9 . - pp. 2816-2820.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.201409846

Abstract in another language

Biofabrication is an emerging and rapidly expanding field of research in which additive manufacturing techniques in combination with cell printing are exploited to generate hierarchical tissue-like structures. Materials that combine printability with cytocompatibility, so called bioinks, are currently the biggest bottleneck. Since recombinant spider silk proteins are non-immunogenic, cytocompatible, and exhibit physical crosslinking, their potential as a new bioink system was evaluated. Cell-loaded spider silk constructs can be printed by robotic dispensing without the need for crosslinking additives or thickeners for mechanical stabilization. Cells are able to adhere and proliferate with good viability over at least one week in such spider silk scaffolds. Introduction of a cell-binding motif to the spider silk protein further enables fine-tuned control over cell–material interactions. Spider silk hydrogels are thus a highly attractive novel bioink for biofabrication.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biofabrication; cell encapsulation; fibroblasts; hydrogels; spider silk
Institutions of the University: Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields > Food and Health Sciences
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Emerging Fields
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 21 Sep 2015 12:18
Last Modified: 20 May 2016 08:40
URI: https://eref.uni-bayreuth.de/id/eprint/19462