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Theory and practical understanding of the migration behavior of proteins and peptides in CE and related techniques

Title data

Freitag, Ruth ; Hilbrig, Frank:
Theory and practical understanding of the migration behavior of proteins and peptides in CE and related techniques.
In: Electrophoresis. Vol. 28 (2007) Issue 13 . - pp. 2125-2144.
ISSN 1522-2683
DOI: https://doi.org/10.1002/elps.200600792

Official URL: Volltext

Abstract in another language

CEC is defined as an analytical method, where the analytes are separated on a chromatographic column in the presence of an applied voltage. The separation of charged analytes in CEC is complex, since chromatographic interaction, electroosmosis and electrophoresis contribute to the experimentally observed behavior. The putative contribution of effects such as surface electrodiffusion has been suggested. A sound theoretical treatment incorporating all effects is currently not available. The question of whether the different effects contribute in an independent or an interdependent manner is still under discussion. In this contribution, the state-of-the-art in the theoretical description of the individual contributions as well as models for the retention behavior and in particular possible dimensionless 'retention factors' is discussed, together with the experimental database for the separation of charged analytes, in particular proteins and peptides, by CEC and related techniques.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: CEC; Migration; Modelling; Proteins; Retention
Institutions of the University: Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag
Faculties
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 24 Feb 2016 15:27
Last Modified: 24 Feb 2016 15:27
URI: https://eref.uni-bayreuth.de/id/eprint/31044