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Gene therapy : designer promoters for tumour targeting

Title data

Nettelbeck, Dirk M. ; Jérôme, Valérie ; Müller, Rolf:
Gene therapy : designer promoters for tumour targeting.
In: Trends in Genetics. Vol. 16 (April 2000) Issue 4 . - 174 - 181.
ISSN 1362-4555
DOI: https://doi.org/10.1016/S0168-9525(99)01950-2

Official URL: Volltext

Abstract in another language

One of the biggest challenges facing cancer therapy is to generate tumour-specific treatment strategies. Gene therapy hopes to achieve this by directing the activity of therapeutic genes specifically to the sites of disease. Of paramount importance for the success of this approach is the availability of tumour-specific delivery systems: both the transductional targeting of the vector vehicle and the restriction of transgene expression to the tumour are promising strategies towards this goal. This review will focus on the recent achievements in the field of transcriptional targeting and the different strategies to improve or design promoters with the desired specificities.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Promoters
Institutions of the University: Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Result of work at the UBT: No
DDC Subjects: 500 Science
500 Science > 500 Natural sciences
600 Technology, medicine, applied sciences
Date Deposited: 26 Feb 2016 11:07
Last Modified: 26 Feb 2016 11:07
URI: https://eref.uni-bayreuth.de/id/eprint/31082