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Eukaryotic Argonautes come into focus


Kuhn, Claus-D. ; Joshua-Tor, Leemor:
Eukaryotic Argonautes come into focus.
In: Trends in Biochemical Sciences. Bd. 38 (Mai 2013) Heft 5 . - S. 263-271.
ISSN 0968-0004
DOI: https://doi.org/10.1016/j.tibs.2013.02.008


Despite the fact that different classes of small RNAs are generated by largely different biogenesis pathways, all mature small RNAs associate with an Argonaute family member to form the RNA-induced silencing complex (RISC). Gene silencing by RISC could not be studied in molecular detail because structural information on eukaryotic Argonautes was lacking. Recently, however, the structure of human Argonaute-2 (hAgo2), a model for RISC function, was determined in complexes with heterogeneous guide RNA and in complexes with a specific miRNA. We review the exciting advances that these two structures, together with the structure of a budding yeast Argonaute, brought to the field of eukaryotic RNA interference (RNAi), and how they will enable a more detailed mechanistic understanding of eukaryotic RISC.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Profilfelder > Advanced Fields > Molekulare Biowissenschaften
Forschungseinrichtungen > Forschungszentren > Bayreuther Zentrum für Molekulare Biowissenschaften - BZMB
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Profilfelder > Advanced Fields
Forschungseinrichtungen > Forschungszentren
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
Eingestellt am: 10 Jan 2017 10:46
Letzte Änderung: 10 Jan 2017 10:46
URI: https://eref.uni-bayreuth.de/id/eprint/35632