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Structure of eukaryotic RNA polymerases


Cramer, Patrick ; Armache, Karim J. ; Baumli, Sonja ; Benkert, Stefan ; Brueckner, Florian ; Buchen, Claudia ; Damsma, Gerke E. ; Dengl, Stefan ; Geiger, Sebastian R. ; Jasiak, Anja J. ; Jawhari, Anass ; Jennebach, Stefan ; Kamenski, Tomislav ; Kettenberger, Hubert ; Kuhn, Claus-D. ; Lehmann, Elisabeth ; Leike, Kristin ; Sydow, Jasmin F. ; Vannini, Alessandro:
Structure of eukaryotic RNA polymerases.
In: Annual Review of Biophysics. Bd. 37 (2008) . - S. 337-352.
ISSN 1936-122X
DOI: https://doi.org/10.1146/annurev.biophys.37.032807.130008


Link zum Volltext (externe URL): Volltext


The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a catalog of available structural information for these three enzymes. Most structural data have been accumulated for Pol II and its functional complexes. These studies have provided insights into many aspects of the transcription mechanism, including initiation at promoter DNA, elongation of the mRNA chain, tunability of the polymerase active site, which supports RNA synthesis and cleavage, and the response of Pol II to DNA lesions. Detailed structural studies of Pol I and Pol III were reported recently and showed that the active center region and core enzymes are similar to Pol II and that strong structural differences on the surfaces account for gene class-specific functions.

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Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: Animals; *DNA-Directed RNA Polymerases/chemistry/genetics/ultrastructure; Enzyme Activation; Humans; *Models, Chemical; *Models, Genetic; Models, Molecular; RNA/*biosynthesis/*chemistry/genetics; Transcription, Genetic/*genetics
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Profilfelder > Advanced Fields > Molekulare Biowissenschaften
Forschungseinrichtungen > Forschungszentren > Bayreuther Zentrum für Molekulare Biowissenschaften - BZMB
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Profilfelder > Advanced Fields
Forschungseinrichtungen > Forschungszentren
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
Eingestellt am: 10 Jan 2017 11:07
Letzte Änderung: 10 Jan 2017 11:07
URI: https://eref.uni-bayreuth.de/id/eprint/35640