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Structure of eukaryotic RNA polymerases

Title data

Cramer, Patrick ; Armache, Karim J. ; Baumli, Sonja ; Benkert, Stefan ; Brueckner, Florian ; Buchen, Claudia ; Damsma, Gerke E. ; Dengl, Stefan ; Geiger, Sebastian R. ; Jasiak, Anja J. ; Jawhari, Anass ; Jennebach, Stefan ; Kamenski, Tomislav ; Kettenberger, Hubert ; Kuhn, Claus-D. ; Lehmann, Elisabeth ; Leike, Kristin ; Sydow, Jasmin F. ; Vannini, Alessandro:
Structure of eukaryotic RNA polymerases.
In: Annual Review of Biophysics. Vol. 37 (2008) . - pp. 337-352.
ISSN 1936-122X
DOI: https://doi.org/10.1146/annurev.biophys.37.032807.130008

Official URL: Volltext

Abstract in another language

The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a catalog of available structural information for these three enzymes. Most structural data have been accumulated for Pol II and its functional complexes. These studies have provided insights into many aspects of the transcription mechanism, including initiation at promoter DNA, elongation of the mRNA chain, tunability of the polymerase active site, which supports RNA synthesis and cleavage, and the response of Pol II to DNA lesions. Detailed structural studies of Pol I and Pol III were reported recently and showed that the active center region and core enzymes are similar to Pol II and that strong structural differences on the surfaces account for gene class-specific functions.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Animals; *DNA-Directed RNA Polymerases/chemistry/genetics/ultrastructure; Enzyme Activation; Humans; *Models, Chemical; *Models, Genetic; Models, Molecular; RNA/*biosynthesis/*chemistry/genetics; Transcription, Genetic/*genetics
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields > Advanced Fields > Molecular Biosciences
Research Institutions > Research Centres > Bayreuth Center for Molecular Biosciences - BZMB
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 10 Jan 2017 11:07
Last Modified: 10 Jan 2017 11:07
URI: https://eref.uni-bayreuth.de/id/eprint/35640