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Ultraporous, compressible, wettable polylactide/polycaprolactone sponges for tissue engineering

Title data

Mader, Michael ; Jérôme, Valérie ; Freitag, Ruth ; Agarwal, Seema ; Greiner, Andreas:
Ultraporous, compressible, wettable polylactide/polycaprolactone sponges for tissue engineering.
In: Biomacromolecules. (2018) .
ISSN 1526-4602
DOI: https://doi.org/10.1021/acs.biomac.8b00434

Official URL: Volltext

Abstract in another language

Ultraporous, biodegradable sponges made of either polylactide or of blends of polylactide/poly(ε caprolactone) are prepared by freeze-drying of dispersions of short electrospun fibers and subsequent thermal annealing. The sponges feature ultrahigh porosity (99.6 %), a hierarchical cellular structure, and high reversible compressibility with fast recovery from deformation in the dry as well as in wet state. The sponge properties depend on the fiber dispersion concentration and the annealing temperature. Sponge characteristics like fiber density (2.5-20 mg/cm3), size, shape, crystallinity, mechanical strength, wetability, and structural integrity are user adjustable. Cell culture experiments were successfully performed with Jurkat cells with Confocal Laser Scanning Microscopy and MTT staining showing rapid cell proliferation and excellent biocompatibility. Live/Dead® staining demonstrated high viability of the seeded cells. The sponge characteristics and modifications investigated and presented here reveal that these sponges are highly promising for tissue engineering applications.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biodegradable; 3D scaffold; tissue engineering; sponge; nonwoven; electrospinning; blend polymer; elastic; reversible compression; cell culturing
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 600 Technology
600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 22 Mar 2018 07:07
Last Modified: 22 Mar 2018 07:07
URI: https://eref.uni-bayreuth.de/id/eprint/43081