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Mitohormesis and metabolic health : the interplay between ROS, cAMP and sirtuins

Title data

Palmeira, Carlos Marques ; Teodoro, João Soeiro ; Amorim, João Alves ; Steegborn, Clemens ; Sinclair, David A ; Rolo, Anabela Pinto:
Mitohormesis and metabolic health : the interplay between ROS, cAMP and sirtuins.
In: Free radical biology and medicine. Vol. 141 (September 2019) . - pp. 483-491.
ISSN 1873-4596
DOI: https://doi.org/10.1016/j.freeradbiomed.2019.07.017

Abstract in another language

The key role of mitochondria in oxidative metabolism and redox homeostasis explains the link between mitochondrial dysfunction and the development of metabolic disorders. Mitochondria's highly dynamic nature, based on alterations in biogenesis, mitophagy, fusion and fission, allows adjusting sequential redox reactions of the electron transport chain (ETC) and dissipation of the membrane potential by ATP synthase, to different environmental cues. With reactive oxygen species being an inevitable by-product of oxidative phosphorylation (OXPHOS), alterations on mitochondrial oxidative rate with a consequent excessive load of reactive oxygen species have been traditionally associated with pathological conditions. However, reactive oxygen species have also been suggested as promoters of mitohormesis, a process in which low, non-cytotoxic concentrations of reactive oxygen species promote mitochondrial homeostasis. Therefore, signaling systems involved in the regulation of mitochondrial homeostasis are attractive candidates for drug development for metabolic diseases triggered by mitochondrial dysfunction. Reversible phosphorylation downstream the cyclic AMP (cAMP) signaling cascade and deacetylation mediated by sirtuins are recognized as major mitochondrial regulators.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Metabolic diseases; Mitochondria; Mitohormesis; ROS; Sirtuin; cAMP
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Clemens Steegborn
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 27 Nov 2019 08:01
Last Modified: 27 Nov 2019 08:01
URI: https://eref.uni-bayreuth.de/id/eprint/53413