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The piRNA pathway in planarian flatworms : new model, new insights

Titelangaben

Kim, Iana ; Riedelbauch, Sebastian ; Kuhn, Claus-D.:
The piRNA pathway in planarian flatworms : new model, new insights.
In: Biological Chemistry. Bd. 401 (2020) Heft 10 . - S. 1123-1141.
ISSN 1437-4315
DOI: https://doi.org/10.1515/hsz-2019-0445

Angaben zu Projekten

Projektfinanzierung: Bayerisches Staatsministerium für Wissenschaft, Forschung und Kunst

Abstract

PIWI-interacting RNAs (piRNAs) are small regulatory RNAs that associate with members of the PIWI clade of the Argonaute superfamily of proteins. piRNAs are predominantly found in animal gonads. There, they silence transposable elements, regulate gene expression and participate in DNA methylation, thus orchestrating proper germline development. What is more, PIWI proteins are also indispensable for the maintenance and differentiation capabilities of pluripotent stem cells in free-living invertebrate species with regenerative potential. Thus, PIWI proteins and piRNAs seem to constitute an essential molecular feature of somatic pluripotent stem cells and the germline. In keeping with this hypothesis, both PIWI proteins and piRNAs are enriched in neoblasts, the adult stem cells of planarian flatworms, and their presence is a prerequisite for the proper regeneration and perpetual tissue homeostasis of these animals. The piRNA pathway is required to maintain the unique biology of planarians because, in analogy to the animal germline, planarian piRNAs silence transposable elements and ensure stable genome inheritance. Moreover, planarian piRNAs also contribute to the degradation of numerous protein-coding transcripts, a function that may be critical for neoblasts differentiation. This review gives an overview of the planarian piRNA pathway and of its crucial function in neoblast biology.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: Planarians; piRNAs; PIWI proteins; Schmidtea mediterranea
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Profilfelder > Advanced Fields > Molekulare Biowissenschaften
Graduierteneinrichtungen > Elitenetzwerk Bayern > Structural Basis of Gene Regulation by Non-coding RNA
Fakultäten
Profilfelder
Profilfelder > Advanced Fields
Graduierteneinrichtungen
Graduierteneinrichtungen > Elitenetzwerk Bayern
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
Eingestellt am: 13 Mär 2020 06:54
Letzte Änderung: 18 Nov 2020 06:37
URI: https://eref.uni-bayreuth.de/id/eprint/54628