Titelangaben
Kim, Iana ; Riedelbauch, Sebastian ; Kuhn, Claus-D.:
The piRNA pathway in planarian flatworms : new model, new insights.
In: Biological Chemistry.
Bd. 401
(2020)
Heft 10
.
- S. 1123-1141.
ISSN 1437-4315
DOI: https://doi.org/10.1515/hsz-2019-0445
Angaben zu Projekten
Projektfinanzierung: |
Bayerisches Staatsministerium für Wissenschaft, Forschung und Kunst |
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Abstract
PIWI-interacting RNAs (piRNAs) are small regulatory RNAs that associate with members of the PIWI clade of the Argonaute superfamily of proteins. piRNAs are predominantly found in animal gonads. There, they silence transposable elements, regulate gene expression and participate in DNA methylation, thus orchestrating proper germline development. What is more, PIWI proteins are also indispensable for the maintenance and differentiation capabilities of pluripotent stem cells in free-living invertebrate species with regenerative potential. Thus, PIWI proteins and piRNAs seem to constitute an essential molecular feature of somatic pluripotent stem cells and the germline. In keeping with this hypothesis, both PIWI proteins and piRNAs are enriched in neoblasts, the adult stem cells of planarian flatworms, and their presence is a prerequisite for the proper regeneration and perpetual tissue homeostasis of these animals. The piRNA pathway is required to maintain the unique biology of planarians because, in analogy to the animal germline, planarian piRNAs silence transposable elements and ensure stable genome inheritance. Moreover, planarian piRNAs also contribute to the degradation of numerous protein-coding transcripts, a function that may be critical for neoblasts differentiation. This review gives an overview of the planarian piRNA pathway and of its crucial function in neoblast biology.
Weitere Angaben
Publikationsform: | Artikel in einer Zeitschrift |
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Begutachteter Beitrag: | Ja |
Keywords: | Planarians; piRNAs; PIWI proteins; Schmidtea mediterranea |
Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie Profilfelder > Advanced Fields > Molekulare Biowissenschaften Graduierteneinrichtungen > Elitenetzwerk Bayern > Structural Basis of Gene Regulation by Non-coding RNA Fakultäten Profilfelder Profilfelder > Advanced Fields Graduierteneinrichtungen Graduierteneinrichtungen > Elitenetzwerk Bayern |
Titel an der UBT entstanden: | Ja |
Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie |
Eingestellt am: | 13 Mär 2020 06:54 |
Letzte Änderung: | 18 Nov 2020 06:37 |
URI: | https://eref.uni-bayreuth.de/id/eprint/54628 |