Convergent Solid-Phase Synthesis of N-Glycopeptides Facilitated by Pseudoprolines at Consensus-Sequence Ser/Thr Residues

Title data

Ullmann, Vera ; Rädisch, Marisa ; Boos, Irene ; Freund, Jutta ; Pöhner, Claudia ; Schwarzinger, Stephan ; Unverzagt, Carlo:
Convergent Solid-Phase Synthesis of N-Glycopeptides Facilitated by Pseudoprolines at Consensus-Sequence Ser/Thr Residues.
In: Angewandte Chemie. Vol. 124 (2012) Issue 46 . - pp. 11734-11738.
ISSN 1521-3757
DOI: https://doi.org/10.1002/ange.201204272

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Abstract in another language

Ferngesteuert: Für Asp-X-Ser/Thr-Peptide, die ein Pseudoprolin enthalten (rot, siehe Schema), ist die Bildung von Aspartimiden bei der Peptidverlängerung und bei konvergenten Zuckerkupplungen stark vermindert. Mit diesem Ansatz gelingt es, komplexe Peptide und N-Glycane effizient an der Festphase zu verknüpfen, sodass Glycopeptide und ‒proteine leichter zugänglich werden.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Institutions of the University:	Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT:	Yes
DDC Subjects:	500 Science 500 Science > 500 Natural sciences 500 Science > 540 Chemistry 500 Science > 570 Life sciences, biology
Date Deposited:	15 Jan 2015 09:22
Last Modified:	13 Sep 2019 08:08
URI:	https://eref.uni-bayreuth.de/id/eprint/5565