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Soybean Oil-Derived Poly-Unsaturated Fatty Acids Enhance Liver Damage in NAFLD Induced by Dietary Cholesterol

Title data

Henkel, Janin ; Alfine, Eugenia ; Saín, Juliana ; Jöhrens, Korinna ; Weber, Daniela ; Castro, José P. ; König, Jeannette ; Stuhlmann, Christin ; Vahrenbrink, Madita ; Jonas, Wenke ; Kleinridders, André. ; Püschel, Gerhard P:
Soybean Oil-Derived Poly-Unsaturated Fatty Acids Enhance Liver Damage in NAFLD Induced by Dietary Cholesterol.
In: Nutrients. Vol. 10 (18 September 2018) Issue 9 .
ISSN 2072-6643
DOI: https://doi.org/10.3390/nu10091326

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

While the impact of dietary cholesterol on the progression of atherosclerosis has probably been overestimated, increasing evidence suggests that dietary cholesterol might favor the transition from blunt steatosis to non-alcoholic steatohepatitis (NASH), especially in combination with high fat diets. It is poorly understood how cholesterol alone or in combination with other dietary lipid components contributes to the development of lipotoxicity. The current study demonstrated that liver damage caused by dietary cholesterol in mice was strongly enhanced by a high fat diet containing soybean oil-derived ω6-poly-unsaturated fatty acids (ω6-PUFA), but not by a lard-based high fat diet containing mainly saturated fatty acids. In contrast to the lard-based diet the soybean oil-based diet augmented cholesterol accumulation in hepatocytes, presumably by impairing cholesterol-eliminating pathways. The soybean oil-based diet enhanced cholesterol-induced mitochondrial damage and amplified the ensuing oxidative stress, probably by peroxidation of poly-unsaturated fatty acids. This resulted in hepatocyte death, recruitment of inflammatory cells, and fibrosis, and caused a transition from steatosis to NASH, doubling the NASH activity score. Thus, the recommendation to reduce cholesterol intake, in particular in diets rich in ω6-PUFA, although not necessary to reduce the risk of atherosclerosis, might be sensible for patients suffering from non-alcoholic fatty liver disease.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: NASH; PUFA; cholesterol; inflammation; non-alcoholic fatty liver disease (NAFLD); oxidative stress
Institutions of the University: Faculties > Faculty of Life Sciences: Food, Nutrition and Health
Faculties
Faculties > Faculty of Life Sciences: Food, Nutrition and Health > Lehrstuhl Biochemie der Ernährung > Lehrstuhl Biochemie der Ernährung - Univ.-Prof. Dr. Janin Henkel-Oberländer
Faculties > Faculty of Life Sciences: Food, Nutrition and Health > Lehrstuhl Biochemie der Ernährung
Result of work at the UBT: No
DDC Subjects: 500 Science
500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 26 Apr 2021 12:23
Last Modified: 17 May 2021 06:53
URI: https://eref.uni-bayreuth.de/id/eprint/64438