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Dietary cholesterol does not break your heart but kills your liver

Title data

Püschel, Gerhard P. ; Henkel, Janin:
Dietary cholesterol does not break your heart but kills your liver.
In: Porto Biomedical Journal. Vol. 3 (August 2018) Issue 1 . - Art.Nr. e12.
ISSN 2444-8664
DOI: https://doi.org/10.1016/j.pbj.0000000000000012

Abstract in another language

It is increasingly accepted that dietary cholesterol has a much lower impact on the progression of cardiovascular disease than previously assumed. However, both animal experiments and human studies seem to support the view that dietary cholesterol may contribute to the transition from benign steatosis to the potentially fatal non-alcoholic steatohepatitis. Cholesterol esters and cholesterol accumulate in the hepatocyte and impair its function. This leads to oxidative stress and endoplasmic reticulum stress triggering the release of pro-inflammatory cytokines and rendering the hepatocyte more susceptible to apoptotic or necrotic cell death. Kupffer cells group around dying hepatocytes and phagocytose the hepatocyte debris and lipids. In addition, they are exposed to lipid peroxidation products released from hepatocytes. Kupffer cells, thus activated, release pro-inflammatory, chemotactic and profibrotic cytokines that promote inflammation and fibrosis. Therefore, dietary cholesterol may be harmful to the liver, in particular when administered in combination with polyunsaturated fatty acids that favor lipid peroxidation.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Western-type diet; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; poly-unsaturated fatty acids
Institutions of the University: Faculties > Faculty of Life Sciences: Food, Nutrition and Health
Result of work at the UBT: No
DDC Subjects: 500 Science
500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 26 Apr 2021 12:36
Last Modified: 26 Apr 2021 12:57
URI: https://eref.uni-bayreuth.de/id/eprint/64442