Literatur vom gleichen Autor/der gleichen Autor*in
plus bei Google Scholar

Bibliografische Daten exportieren
 

Enhanced Palmitate-Induced Interleukin-8 Formation in Human Macrophages by Insulin or Prostaglandin E₂

Titelangaben

Henkel-Oberländer, Janin ; Klauder, Julia ; Statz, Meike ; Wohlenberg, Anne-Sophie ; Kuipers, Sonja ; Vahrenbrink, Madita ; Püschel, Gerhard Paul:
Enhanced Palmitate-Induced Interleukin-8 Formation in Human Macrophages by Insulin or Prostaglandin E₂.
In: Biomedicines. Bd. 9 (2021) Heft 5 . - 449.
ISSN 2227-9059
DOI: https://doi.org/10.3390/biomedicines9050449

Abstract

Macrophages in pathologically expanded dysfunctional white adipose tissue are exposed to a mix of potential modulators of inflammatory response, including fatty acids released from insulin-resistant adipocytes, increased levels of insulin produced to compensate insulin resistance, and prostaglandin E (PGE) released from activated macrophages. The current study addressed the question of how palmitate might interact with insulin or PGE to induce the formation of the chemotactic pro-inflammatory cytokine interleukin-8 (IL-8). Human THP-1 cells were differentiated into macrophages. In these macrophages, palmitate induced IL-8 formation. Insulin enhanced the induction of IL-8 formation by palmitate as well as the palmitate-dependent stimulation of PGE synthesis. PGE in turn elicited IL-8 formation on its own and enhanced the induction of IL-8 release by palmitate, most likely by activating the EP4 receptor. Since IL-8 causes insulin resistance and fosters inflammation, the increase in palmitate-induced IL-8 formation that is caused by hyperinsulinemia and locally produced PGE in chronically inflamed adipose tissue might favor disease progression in a vicious feed-forward cycle.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: Inflammation; Insulin; Interleukin-8; Macrophages; Prostaglandin E2
Institutionen der Universität: Fakultäten > Fakultät für Lebenswissenschaften: Lebensmittel, Ernährung und Gesundheit
Fakultäten
Fakultäten > Fakultät für Lebenswissenschaften: Lebensmittel, Ernährung und Gesundheit > Lehrstuhl Biochemie der Ernährung > Lehrstuhl Biochemie der Ernährung - Univ.-Prof. Dr. Janin Henkel-Oberländer
Fakultäten > Fakultät für Lebenswissenschaften: Lebensmittel, Ernährung und Gesundheit > Lehrstuhl Biochemie der Ernährung
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
Eingestellt am: 07 Mai 2021 07:41
Letzte Änderung: 01 Jun 2023 11:45
URI: https://eref.uni-bayreuth.de/id/eprint/65110