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Enhanced Palmitate-Induced Interleukin-8 Formation in Human Macrophages by Insulin or Prostaglandin E

Title data

Henkel-Oberländer, Janin ; Klauder, Julia ; Statz, Meike ; Wohlenberg, Anne-Sophie ; Kuipers, Sonja ; Vahrenbrink, Madita ; Püschel, Gerhard Paul:
Enhanced Palmitate-Induced Interleukin-8 Formation in Human Macrophages by Insulin or Prostaglandin E.
In: Biomedicines. Vol. 9 (21 April 2021) Issue 5 . - No. 449.
ISSN 2227-9059
DOI: https://doi.org/10.3390/biomedicines9050449

Abstract in another language

Macrophages in pathologically expanded dysfunctional white adipose tissue are exposed to a mix of potential modulators of inflammatory response, including fatty acids released from insulin-resistant adipocytes, increased levels of insulin produced to compensate insulin resistance, and prostaglandin E (PGE) released from activated macrophages. The current study addressed the question of how palmitate might interact with insulin or PGE to induce the formation of the chemotactic pro-inflammatory cytokine interleukin-8 (IL-8). Human THP-1 cells were differentiated into macrophages. In these macrophages, palmitate induced IL-8 formation. Insulin enhanced the induction of IL-8 formation by palmitate as well as the palmitate-dependent stimulation of PGE synthesis. PGE in turn elicited IL-8 formation on its own and enhanced the induction of IL-8 release by palmitate, most likely by activating the EP4 receptor. Since IL-8 causes insulin resistance and fosters inflammation, the increase in palmitate-induced IL-8 formation that is caused by hyperinsulinemia and locally produced PGE in chronically inflamed adipose tissue might favor disease progression in a vicious feed-forward cycle.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Inflammation; Insulin; Interleukin-8; Macrophages; Prostaglandin E2
Institutions of the University: Faculties > Faculty of Life Sciences: Food, Nutrition and Health
Faculties
Faculties > Faculty of Life Sciences: Food, Nutrition and Health > Lehrstuhl Biochemie der Ernährung > Lehrstuhl Biochemie der Ernährung - Univ.-Prof. Dr. Janin Henkel-Oberländer
Result of work at the UBT: Yes
DDC Subjects: 500 Science
500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 07 May 2021 07:41
Last Modified: 17 May 2021 06:52
URI: https://eref.uni-bayreuth.de/id/eprint/65110