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High Strength and High Toughness Electrospun Multifibrillar Yarns with Highly Aligned Hierarchy Intended as Anisotropic Extracellular Matrix

Title data

Liao, Xiaojian ; Jérôme, Valérie ; Agarwal, Seema ; Freitag, Ruth ; Greiner, Andreas:
High Strength and High Toughness Electrospun Multifibrillar Yarns with Highly Aligned Hierarchy Intended as Anisotropic Extracellular Matrix.
In: Macromolecular Bioscience. (September 2022) . - No. 2200291.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.202200291

Official URL: Volltext

Abstract in another language

Abstract Electrospun nanofibers can be effectively used as a surrogate for extracellular matrices (ECMs). However, in the context of cellular mechanobiology, their mechanical performances could be enhanced by using nanofibrous materials with a high level of structural organization. Herein, we developed multifibrillar yarns with superior mechanical performance based on biocompatible polyacrylonitrile as surrogate ECM. Nearly-perfect aligned nanofibers along with the axis of the multifibrillar yarn were prepared. These highly aligned yarns exhibit high strength, high toughness, good stress relaxation behavior, and are robust enough for technical or medical applications. Further, we analyzed the influence of the highly aligned-hierarchical topological structure of the material on cell proliferation and cell orientation using cells derived from epithelial and connective tissues. Compared to non-oriented electrospun multifibrillar yarns and flat films, the well-ordered topology in the electrospun polyacrylonitrile multifibrillar yarns triggers an improved proliferation of fibroblasts and epithelial cells. The fibroblast acquired an elongated morphology analogous to their behavior in the natural ECM. Hence, this heterogeneous multifibrillar material could be used to restore or reproduce the ECM for tissue engineering applications, notably in the skeletal muscle and tendon. This article is protected by copyright. All rights reserved

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 600 Technology
600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 22 Sep 2022 14:05
Last Modified: 09 Nov 2022 08:17
URI: https://eref.uni-bayreuth.de/id/eprint/71945