Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes

Title data

Rattani, Ahmed ; Wolna, Magda ; Ploquin, Mickael ; Helmhart, Wolfgang ; Morrone, Seamus ; Mayer, Bernd ; Godwin, Jonathan ; Xu, Wenqing ; Stemmann, Olaf ; Pendas, Alberto ; Nasmyth, Kim:
Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes.
In: eLIFE. Vol. 2 (5 November 2013) Issue e01133 .
ISSN 2050-084X
DOI: https://doi.org/10.7554/eLife.01133.001

Official URL: Volltext

Abstract in another language

Accurate chromosome segregation depends on coordination between cohesion resolution and kinetochore-microtubule interactions (K-fibers), a process regulated by the spindle assembly checkpoint (SAC). How these diverse processes are coordinated remains unclear. We show that in mammalian oocytes Shugoshin-like protein 2 (Sgol2) in addition to protecting cohesin, plays an important role in turning off the SAC, in promoting the congression and bi-orientation of bivalents on meiosis I spindles, in facilitating formation of K-fibers and in limiting bivalent stretching. Sgol2’s ability to protect cohesin depends on its interaction with PP2A, as is its ability to silence the SAC, with the latter being mediated by direct binding to Mad2. In contrast, its effect on bivalent stretching and K-fiber formation is independent of PP2A and mediated by recruitment of MCAK and inhibition of Aurora C kinase activity respectively. By virtue of its multiple interactions, Sgol2 links many of the processes essential for faithful chromosome segregation. - See more at: http://elifesciences.org/content/2/e01133#sthash.k6YlGhgC.dpuf

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics > Chair Genetics - Univ.-Prof. Dr. Olaf Stemmann
Profile Fields > Advanced Fields > Molecular Biosciences
Research Institutions > Research Centres > Bayreuth Center for Molecular Biosciences - BZMB
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 26 Mar 2015 07:53
Last Modified: 30 Mar 2015 10:23
URI: https://eref.uni-bayreuth.de/id/eprint/8383